2,206 research outputs found
Letter from Dr. Thomas F. Strasser to Mary Farrell
No full textProvidence College Department of Theatre, Dance & Film
Letter from Dr. Thomas F. Strasser to Mary Farrell about the production of Lysistrata.https://digitalcommons.providence.edu/lysistrata_commentary/1000/thumbnail.jp
Letter from Dr. Thomas F. Strasser to Mary Farrell
No full textProvidence College Department of Theatre, Dance & Film
Letter from Dr. Thomas F. Strasser to Mary Farrell about the production of Lysistrata.https://digitalcommons.providence.edu/lysistrata_commentary/1000/thumbnail.jp
Megaphyllum metsovoni Strasser 1976
No full textMegaphyllum metsovoni (Strasser, 1976) Figs 3 a–f Chromatoiulus metsovoni Strasser, 1976: 614 –616, Figs 52–56. Chromatoiulus metsovoni: Ceuca 1992: 425. Megaphyllum metsovoni: Enghoff & Kime 2009; Lazányi et al. 2012: 17, 19, 41, Figs 10–14. Material examined. Greece: holotype male, Greece (Epire), coll. de Metsovon, pâturages avec Rhododendron, 28.4. 1973, B. Hauser leg. (NHMG) Distribution. Greece (Strasser 1976; Lazányi et al. 2012). Diagnosis. Differs from all consubgeners by the bent, plate-like anterior process of the opisthomere (ap), most visible from lateral view (Fig. 3 d). Opisthomere’s (Figs 3 a–b, 3 d) posterior process (pp) thin and reaching the height of solenomere. Solenomere’s processes (asp and psp) subequal in length. Both sexes are reddish-brown with two bright longitudinal dorsal bands. Body length and height: males: 31– 37.6mm, 2–2.5mm; female (Strasser 1976): 34mm, 3mm. Remarks. Endemic species to Greece. Female vulva unknown.Published as part of Lazányi, Eszter & Vagalinski, Boyan, 2013, Redefinition of the millipede subgenus Megaphyllum sensu stricto Verhoeff, 1894 and neotype designation for Megaphyllum austriacum (Latzel, 1884) (Myriapoda: Diplopoda: Julida: Julidae), pp. 55-100 in Zootaxa 3741 (1) on pages 61-62, DOI: 10.11646/zootaxa.3741.1.2, http://zenodo.org/record/22377
Three-terminal mid-IR tunable emitters based on Wannier-stark ladder transitions in semiconductor superlattices
No full text
Author comment on RC4: 'Review of Strasser et al.: Rofental catchment', Adam Winstral, 02 Oct 2017
No full textA conceptual framework for cautious escalation of anticancer treatment: How to optimize overall benefit and obviate the need for de-escalation trials.
No full textBACKGROUND
The developmental workflow of the currently performed phase 1, 2 and 3 cancer trial stages lacks essential information required for the determination of the optimal efficacy threshold of new anticancer regimens. Due to this there is a serious risk of overdosing and/or treating for an unnecessary long time, leading to excess toxicity and a higher financial burden for society. But often post-approval de-escalation trials for dose-optimization and treatment de-intensification are not performed due to failing resources and time. Therefore, the developmental workflow needs to be restructured toward cautious systemic cancer treatment escalation, in order to guarantee optimal efficacy and sustainability.
METHODS
In this manuscript we discuss opportunities to produce the information needed for cautious escalation, based on models of cancer growth and cancer kill kinetics as well as exploratory biomarkers, for the purpose of designing the optimal phase 3 superiority trial. Subsequently, we compare the sample size needed for a phase 3 superiority trial, followed by a necessary de-escalation trial with the sample size needed for a multi-arm phase 3 trial with intervention arms of differing intensity. All essential items are structured within a Framework for Cautious Escalation (FCE). The discussion uses illustrations from the breast cancer setting, but aims to be applicable for all cancers.
RESULTS
The FCE is a promising model of clinical development in oncology to prevent overtreatment and associated issues, especially with regard to the number of repetitive treatment cycles. It will hopefully increase the relevance and success rate of clinical trials, to deliver improved patient-centric outcomes
Historia del Monte Celia de Nuestra Señora de la Salceda ...
No full textCopia digital : Biblioteca Digital Hispánica (Biblioteca Nacional de España)El pie de imprenta consta en colofón, en signatura A\b4\s v. del primer cuaderno A\p8\sEl pie de imp. consta en colofón, en sign. A\b4\s v. del primer cuaderno A\p8\sSign.: [ ]\p1\s, A\p8\s, A-Z\p8\s, 2A-2Z\p8\s, 3A-3K\p8\s, [parágrafo]\p8\s, A-D\p8\s, E\p4\sPortada grabada calcográfica : "F. Heyla me fecit Granata"Las páginas 358 a 383 con retratos grabados calcográficos de todos los obispos y arzobispos de Granada hasta 1616En recto de sign.atura A\b7\s (del primer cuaderno de A\b8\s) escudo calcográfico de la Infanta Margarita de Austria y otro grabado calcográfico en página 69Una hoja de grabado calcográfico: "F. Heylan fecit", de la Virgen de la SalcedaDe las [4] h.ojas de grabado calcográfico plegables: dos firmadas por el franciscano Hieronymus Strasser (una de ellas de la Virgen de la Salceda) y las otras dos por F. Heylan (una es el retablo donde está colocada la Virgen y otra la Capilla de reliquias)Port. grab. calc. : "F. Heyla me fecit Granata"Las p. 358 a 383 con retratos grab. calc. de todos los obispos y arzobispos de Granada hasta 1616En recto de sign. A\b7\s (del primer cuaderno de A\b8\s) esc. calc. de la Infanta Margarita de Austria y otro grab. calc. en p. 69Una h. de grab. calc.: "F. Heylan fecit", de la Virgen de la SalcedaDe las [4] h. de grab. calc. pleg.: dos firmadas por el franciscano Hieronymus Strasser (una de ellas de la Virgen de la Salceda) y las otras dos por F. Heylan (una es el retablo donde está colocada la Virgen y otra la Capilla de reliquias
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