1,721,107 research outputs found
Bacterial Extracts as Immunomodulators for the Prevention of Recurrent Respiratory Infections in Children
Full text linkAcute respiratory tract infections (ARTI) are the more frequent causes of morbidity and mortality in children. This review was conducted to assess the existing evidence concerning bacterial extracts efficacy in the prevention of pediatric ARTI. The data sources for the identification of clinical trials and reviews included principal bibliographic databases (MEDLINE, Embase, Cochrane Library, PubMed/www.ncbi.nlm.nih.gov). Selected clinical trials only involved children suffering from recurrent ARTI. Bacterial extracts may reduce the incidence of ARTI of about 40% in toddlers (2-5 years), school boys (6-12 years) and children at higher ARTI risk (e.g. children living in orphanages). Among others, the active treatment with OM-85 led to 26, 2% fewer patients with recurrent ARTI. Data from the literature are encouraging, particularly for treatment with OM-85. The strengthening of pre-clinical and clinical research is necessary to allow routine recommendation of bacterial extracts prescription for ARTI prevention in children
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Stratigraphic versus structural control on the deformation pattern associated with the evolution of the Mt. Catria anticline, Italy
No full textHyper IgE syndrome : a case report
No full textBackground and aims: The hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, rash, and recurrent bacterial infections of the skin and lung. Methods: We report a case of a 13-year old boy from Sri-Lanka. The boy has been suffering from atopic dermatitis since first months of life, and from recurrent allergic asthma since the age of 2. Pustular lesions with a tendency toward formation of multiple abscesses appeared all from August 2011 and were always treated with antibiotic therapy. Results: In June 2012, the child was admitted to our department due to fever and abdominal pain that started 5 days prior to admission. Blood test results: PCR = 93,4 mg/L (normal value < 10 mg/L), Mycoplasma Pneumoniae serological Immunoglobulin (Ig) M positive, Ig E level = 10,428 UI/mL (normal value < 100 UI/mL). Mantoux test was negative. Chest X-ray showed a consolidation area, which looked like a pulmonary abscess. CT imaging confirmed the diagnosis. Clinical and radiological improvement was not achieved despite antibiotic treatment with ceftazidime and clarithromycin. The abscess was drained and Methicillin resistant (MRSA) Staphilococcus aureus was isolated. Considering the clinical features, IgE values and etiology of abscess, a diagnosis of Hyper-IgE syndrome was stated. Antibiotic therapy with vancomycin was started, and clinical condition improved. Identification of STAT3 mutation is still ongoing. Conclusion: complications of pulmonary infections are the most common causes of death in hyper-Ig E syndrome. Introduction of comprehensive treatment, including prophylaxis, decreases the recurrences
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