1,721,067 research outputs found
AN IN VITRO STUDY TO EVALUATE THE EPIGENETIC MODIFICATIONS INDUCED BY PARTICULATE MATTER AND NANOPARTICLES
No full textAir pollution exposure, a leading cause of global mortality associated with 800,000 deaths every year, represents a major concern in cities in Europe and worldwide. Once thought to pose a threat principally to the lungs, the overall evidence on heart disease and stroke now indicates that the foremost adverse effects of air pollutants are actually on the cardiovascular system. Recent evidence indicates that air pollution exposure is associated with increased risk of VTE. Although air pollution exposure has been related with systemic inflammation, oxidative stress, and hypercoagulability, mechanisms linking inhalation of air pollutants with enhanced thrombosis and VTE are still largely unclear. Toxic metals, such as lead, arsenic, cadmium, nickel, and others, are abundant in ambient PM, often loosely bound on the particle surface, and their uptake into lung macrophages is considered a primary determinant of PM-induced inflammation.
Nanoparticles are emitted from natural (e.g., volcano) and anthropic (e.g., traffic) sources, and produced via nanotechnology. Fast propagation of nanotechnologies into different industries and consumer products is causing exponential growth of nano-materials production. Hence, increasing amounts of nanoparticles reach occupational settings and the indoor and outdoor environments, thus representing a potentially serious hazard to people’s health. Although they are small solid particles, it is most useful to think of nanoparticles as a different state of matter, even from the point of view of health hazard identification and risk assessment. The risk presented by some nanoparticles may resemble that of fine and ultrafine particulate air pollution, which show an exposure-response relationship but no toxicity threshold, have the capacity to migrate in the body to reach target organs other than the lung (e.g., heart, vessels, CNS), and exert their effects on healthy subjects and not only in susceptible population subgroups. However, the mechanism by which nanoparticles interact with biological systems are relatively unknown and the toxicological, eco-toxicological and exposure data needed to perform a complete risk analysis are lacking. DNA methylation is a reversible epigenetic mechanism that, in mammals, modifies genome function through the addition of methyl groups to cytosine to form 5-methyl-cytosine (5mC).
Initial results from our and other laboratories have shown that air pollution exposures induce changes in DNA methylation that can be detected in blood leukocyte DNA.
Main hypothesis of the project is that PM and nanoparticles exposure may have an impact on human health, in particular through epigenetic modifications, other than through genetic alterations and biochemical pathways. To address this hypothesis we treated the A549 cell line with different doses of PM and with different doses and type of nanoparticles and we evaluated changes in gene expression focusing on inflammatory and cancer pathways.
Our specific hypotheses, based not only on the literature but on preliminary data we obtained, is that PM and nanoparticles are able to trigger a cascade of events (oxidative stress, dysregulation of apoptosis, inflammation, etc) that may eventually lead to cytoxicity, genotoxic alterations and carcinogenesis. There is evidence indicating that these alterations could be determined at the epigenetic level (DNA methylation level).
The translational perspective of the project is to identify hazards and assess the risks associated with exposure to PM and nanoparticles. This should assist decision makers in adopting measures suitable to avoid, or at least minimize, harm to the health and safety. In particular about nanoparticles this study could be important in assessing whether current occupational exposure limits are sufficiently protective when applied to agents that are produced or manipulated in nanoforms
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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