1,721,386 research outputs found
Sostenibilità sulla carta.
No full textLe strategie del settore di produzione di articoli in carta di fronte alle nuove sfide della sostenibilità e del consumo consapevole, in grado di influenzare le tendenze del mercato e di incidere sulle scelte e sui comportamenti delle imprese
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
GENETIC BIOMARKERS OF RENAL FUNCTION
Full text linkABSTRACT
The present study is part of HYPERGENES Project, focused on the
definition of a comprehensive genetic-epidemiological model of complex
traits like essential hypertension and of intermediate phenotypes related
to hypertension. We specifically focused on the identification of genetic
biomarkers related to Glomerular Filtration Rate (GFR) as index of renal
function.
Chronic kidney disease (CKD), defined as either kidney damage or
decreased kidney function for 3 or more months (GFR < 60 ml/min per
1.73m2) affects about 6-11% of the general population. A strong
relationship has been reported between renal dysfunction, hypertension
and cardiovascular diseases; hypertension is present in more than 80% of
patients with CKD and contributes to progression to end stage renal
disease and to cardiovascular events as well.
Apart from the risk conferred by traditional cardiovascular risk factors,
eGFR has a strong genetic component. We therefore performed a
genotype-phenotype association analysis in subjects affected by essential
hypertension and in a population based cohort. The analyses have been
carried on using: 1) 1,634 hypertensives from the HYPERGENES Discovery
phase and 1,198 hypertensives from the HYPERGENES Validation phase;
2) 2,697 subjects from Epogh-Flemengho population based sample 3)
1,952 subjects from Epogh-Flemengho population based sample with GFR
follow-up data, using the difference between the last and the first
measurement as phenotype of renal function.
Using a Genome wide association (GWA) approach, in the HYPERGENES
Discovery sample we identified a potential novel variant associated with
hypertension and renal function in STAC gene (rs4678878, p-value of
3.83x10-8). This gene is likely involved in a neuron-specific signal
transduction, although its function is not yet completely clear. This result
was not validated in HYPERGENES Validation and in the population based
studies. The finding needs further investigation performing a fine
mapping of the region.
Through a candidate gene approach, we could identify some variants,
mapping in genes already known as associated to renal function (PPARA,
CST3-CST9 region, PRKAG2, ABCA1, NEDD4L).
The identification of genetic variants affecting renal function could help
to better understand not only the GFR variability in the general
population but also the pathophysiology of CKD and progressive kidney
function decline. Ultimately, this could lead to novel tools for diagnosis,
prevention and therapy of CKD
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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