112 research outputs found

    Triorganotin compounds as antimicrobial agents

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    Six triorganotin derivatives of thiolupinine(1-mercaptolupinane), 2-mercaptobenzoxazole and 2-mercaptobenzothiazole were prepared and tested against several bacteria, fungi and protozoa. Most compounds exhibited high activity against the tested microorganisms and particularly worth noting was the activity of triethyltin lupinylsulfide on Gram-negative strains. Triethylgermanium lupinylsulfide was also prepared but was devoid of action on the whole set of tested microorganims

    Gold(I) complexes as antimicrobial agents

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    Seven gold complexes were prepared and investigated for biocidal activity against Gram-positive and -negative bacteria, fungi and protozoa. All of them were active against the tested microorganisms with the exception of Pseudomonas aeruginosa. In many cases minimum inhibitory concentrations (MIC) were well below 1 mu g/ml. The activity is not simply related to the gold content. but also to the nature of both the phosphine and the aminothiol to which the metal is bound
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