1,720,979 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Light-activated drugs to restore neuronal activity in neurological disorders
Get PDFThe lack of tissue selectivity of conventional systemic pharmacological agents has long sparked the desire for compounds enabling on demand, localized control. Even drugs with highly selective pharmacological profiles act on their target at unintended organs and locations, with pharmacokinetics that cannot be externally altered. Consequently, the predominant unselective and fixed kinetics of action of conventional pharmacological agents pose significant challenges, particularly in treating neurological disorders such as stroke, traumatic brain injury, Parkinson’s and Alzheimer’s diseases, and schizophrenia.Photopharmacology has emerged as a promising avenue, providing reversible control of endogenous receptor activity with high spatiotemporal resolution by photoswitching ligands between an active and an inactive isomer.Here, we report novel photoswitchable drugs, named neuroswitches, that remain inactive in the dark but can be activated under orange, red, and infrared light, capable of penetrating the skull. These compounds demonstrate photoreversible efficacy both in vitro and in vivo, with no observed acute toxicity. Our proposed approach entails systemic delivery of the inactive neuroswitch followed by precise spatiotemporal activation using light patterns within the targeted region (e.g., the area surrounding a neurologically damaged site). This strategy aims to regulate neuronal activity while avoiding systemic adverse effects associated with conventional pharmacological interventions
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Drug loading strategies for discotic amphiphile supramolecular polymers in water
No full text(08) BTA-based supramolecular polymers are interesting systems for medical applications because of their high dynamicity and stimuli responsiveness in water [1]. Recently, IBEC developed a new class of BTA-based supramolecular polymers which showed responsiveness to temperature, salt concentration, pH, and light [2]. This versatility makes this new class of self-assembled fibers appealing for drug delivery purposes. In this work, we explored two strategies to incorporate different biologically active ligands into these polymers and demonstrate their employability as light-driven drug delivery systems. In the first strategy, we used a co-assembly approach in which two new discotic BTAazo- monomers assemble forming the final helicoidal supramolecular fibers. In the second one, we decided to cage Photoiperoxo [3], a potent photoswitchable derivative of the mAChR agonist Iperoxo [3]. Here, the interaction is based on the stacking between the azobenzene units of the ligand and the monomers. From the first approach, we obtained satisfying co-assemby results which were evaluated by transmission electron microscopy. Remarkably, the second system showed light-dependent biological effects in calcium imaging experiments on cells overexpressing M1 mAChRs. While caged Photoiperoxo did not evoke significant changes, UV pre-illuminated fibers caused an increase in intracellular calcium levels because of the activation of M1 mAChRs by the uncaged ligand. These results suggest that the new class of BTA-based supramolecular polymers [2] can potentially be used as light-driven drug delivery system for small, planar and amphiphilic drugs.
References
[1] Kantekin, S.; de Greef, T.F.A.; Palmans, A.R.A. Chemical Society Reviews. 2012, 41, 6125-6137.
[2] Fuentes E.; Gerth M.; Berrocal J.A.; Matera C.; Gorostiza P.; Voets I.K.; Pujals S.; Albertazzi L. J Am Chem Soc. 2020, 142, 10069-10078.
[3] Agnetta, L.; Bermudez, M.; Riefolo, F.; Matera, C.; Claro, E.; Messerer, R.; Littmann, T.; Wolber, G.; Holzgrabe, U.; Decker, M. Journal of Medicinal Chemistry. 2019, 62, 3009-3020
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
