1,720,964 research outputs found
Immunodetection of breast cancer cells in bone marrow for monitoring high-dose sequential chemotherapy
No full textThe immunodetection of breast-cancer cells in bone marrow may be a useful technique for monitoring the efficiency of chemotherapy in selected clinical settings. We used monoclonal antibodies against cytokeratins and an epithelial membrane antigen pool to detect microscopic metastatic deposits in bone marrow aspirates from a high-risk patient before and after high-dose sequential chemotherapy. In the slides done before therapy, 250 immunostained cells were found, but only 20 immunostained cells were found in slides made after chemotherapy. Moreover, double-staining procedures showed consistent colocalization of the two markers on the same cancer cells. A fraction of the micrometastatic cells were additionally immunostained for Ki-67, a well-established marker of cell proliferation. These data suggest that the immunodetection of breast cancer cells in bone marrow may have potential clinical implications in the management of high-risk breast cancer
Is the presence of laminin receptor an independent prognostic factor in breast cancer? Preliminary results.
No full textPositive immunostaining with MLuC1 of bone marrow aspirate predicts poor outcome in patients with small-cell lung cancer
No full textBackground: Immunocytochemistry has been proven able to identify tumor cells in bone marrow aspirate (BMA) of patients with SCLC. However, few data exist about the clinical significance of the procedure. Patients and methods: 108 BMA taken from 60 patients were incubated with the MoAb MLuCl (cluster 6) and stained by the APAAP (alkaline phosphatase-antialkaline phosphatase) method. The serum levels of LDH, TPA, NSE and CEA were also studied in relation to bone marrow involvement by means of discriminant analysis. Results.' Immunocytochemistry of the aspirate with MLuC1 detected positive cells in 23 patients (38%) (38 of 108 samples) vs. 13% of the conventional biopsies studied without MLuCl (P < 0.001). With respect to bone marrow positivity, three groups of patients were identified: those with no positive cells in the aspirate and negative biopsy (group A); those with less than 10 positive cells in the aspirate and negative biopsy (group B); and those with more than 10 positive cells or clumps in the aspirate or positive biopsy (group c). Group C patients had poorer median survivals than those in the other two groups (5.5 vs. 11 months, respectively, P = 0.01). Discriminant analysis showed that the four serum markers were poor discriminators of the degree of bone marrow involvement, with only 55% of grouped cases being correctly classified. Conclusions: These results show that detection of bone marrow involvement i) can be improved by the use of MLuCl ii) is not predictable by conventional tumor markers, and iii) is related to poor outcome
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Bone marrow micrometastases in 110 breast cancer patients correlations with clinical-pathological features and prognosis.
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