1,720,960 research outputs found
Should sports activity be encouraged or contraindicated in hypertensive subjects?
No full textHypertension is considered one of the major risk factors for
cardiovascular disease. There are a number of different
approaches to the prevention, control and treatment of
hypertension. One of these provides lifestyle modification
as a means to facilitate drug step-down or drug withdrawal
in hypertensive patients subjected to a pharmacological
treatment, but also as a means to control blood pressure
and reduce the risk of developing hypertension in subjects
that have abnormal blood pressure but are not candidates
for drug therapy. Lifestyle modification includes physical
activity, and there is an ever-increasing amount of evidence
that physical activity can modify the history of hypertension,
acting as a reducer either of blood pressure or of the other
cardiovascular risk factors. The aim of this article was to
analyse the effects of exercise on blood pressure (neurohormonal,
hormonal and vessel effects), illustrate which are the influences of age and gender on exercise-induced
reduction of blood pressure, indicate how much exercise (in
terms of intensity, frequency and duration) is required to
induce positive modification of blood pressure and evaluate
current Italian criteria for sports ability in athletes with
hypertensio
DETERMINATION OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN SURFACE WATER AND WASTEWATER BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
No full textAn analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics: Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac and the decomposition product of acetylsalicylic acid: salicylic acid. The selected compounds are acidic, very polar and all are analgesic compounds that can be purchased without medical prescription. Sample enrichment of water samples was achieved by solid-phase extraction procedure (SPE), using Waters Oasis HLB cartridges followed by LC-MS-MS. A narrow-bore 2.1 min i.d., reversed phase LC C-18 column was used to chromatograph analytes. Average recoveries from 1 L samples varied 75-95% and the detection limits are <1 ng L-1. The method developed was applied to real samples from wastewater and surface waters of Lazio country (Italy)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
QUADRUPOLE TIME-OF-FLIGHT VERSUS TRIPLE-QUADRUPOLE MASS SPECTROMETRY FOR THE DETERMINATION OF NON STEROIDAL ANTIINFLAMMATORY DRUGS IN SURFACE WATER BY LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY
No full textA triple-quadrupole instrument and a hybrid quadrupole/time-of-flight (TOF) mass spectrometer were compared for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac. The recently introduced Q2-pulsing function, which enhances the transmission of fragment ions of a selected m/z window from the collision cell into the TOF analyzer, improved the sensitivity of product ion scans on the quadrupole/TOF instrument. The selectivity is much better on quadrupole/TOF systems than on triple quadrupoles because the high resolving power of the reflectron-TOF mass analyzer permits high-accuracy fragment ion selection. This minimizes interferences from environmental matrices and allows acquisition of full spectra for selected analytes with better signal-to-noise characteristics than comparable spectra obtained with a scanned quadrupole. The qualitative information obtained (mass accuracy, resolution and full-scan spectra) by hybrid quadrupole/TOF mass spectrometry allows a more certain identification of analytes in environmental matrices at trace levels. Sample enrichment of water samples was achieved by a solid-phase extraction procedure. Average recoveries for loading 1 L of samples varied from 88 to 110%, and the quantification limits were less than 1.2 ng/L for the triple-quadrupole instrument (in MRM mode) and less than 3 ng/L for the quadrupole/TOF instrument. Copyright (C) 2003 John Wiley Sons, Ltd
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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