33 research outputs found
Esposizione nell’infanzia ed asma nell’adulto
No full textEsposizione nell’infanzia ed asma nell’adult
Intra-operative frozen section technique for breast cancer: end of an era.
No full textData on 2436 primary breast carcinomas diagnosed between 1992 and 2006 were collected to evaluate the rate of frozen section procedures performed over time. Frozen section procedures performed to evaluate resection margins for conservative surgery or sentinel node status were excluded. Over time, there was a decrease in the use of frozen sections indistinctly extended to all pT cancer categories. The rate of cancers diagnosed with frozen sections was 51.2% in 1999, and 0% in 2005-2006. In the same period, the adoption of core biopsyand core biopsy for breast cancer diagnosis increased from 40% in 1992 to more than 90% since 1999. In an audited diagnostic activity on breast pathology, the routine use of frozen sections on primary lesions was considered inappropriate, particularly in assessment of clinically non-palpable lesions, and should be limited to cases with inadequate pre-surgical sampling
Laparoscopic partial resection and mucosectomy of pyloric duplication cyst
No full textThe Authors describe the laparoscopic procedure in the tratement of pyloric suplication cyst in childre
Laparoscopic partial resection and mucosectomy of pyloric duplication cyst
No full textThe Authors describe the laparoscopic procedure in the tratement of pyloric suplication cyst in childre
What's new in mesothelioma
No full textMalignant pleural mesothelioma is a neoplasm characterized by a very poor prognosis and medico-legal implications. Diagnosis, prognosis and therapy are often challenging and include several issues. Cytological diagnosis is frequently the first step of the diagnostic process, and although its sensitivity may be somewhat lower, diagnostic criteria should be taken into account. When effusion cytology is inconclusive for the diagnosis, tissue biopsies should be taken. Even if the morphologic criteria for deciding whether a mesothelial proliferation is a benign or a malignant process have been defined, the separation of benign from malignant mesothelial proliferation is often a difficult problem for the pathologist, particularly on small biopsies. Thirdly, when the diagnosis is made, despite many efforts have been made to identify possible new biomarkers for early diagnosis, prognostic stratification and also predictive tools should be defined. Nowadays, the main prognostic parameter is still represented by the histological subtype, having the epithelioid MPM a better outcome than the sarcomatoid or biphasic MPM. A nuclear grading system have been also proposed to stratify patient outcome. Reliable predictive biomarkers are still lacking in MPM and a personalized therapeutic concept is eagerly needed. Mesothelioma occurs mostly as sporadic cancer and the main risk factor is asbestos exposure, but it also occurs among blood relatives suggesting possible increased genetic susceptibility besides shared exposures. Recently the study of genetic predisposition syndrome raised new aspect in the occurrence of mesothelioma cases
Laparoscopèic partial resection and mucosectomy of pyloric duplication cysts
No full textThe Authors describe the laparoscopic treatment of a pediatric patient with a pyloric duplication cys
Laparoscopèic partial resection and mucosectomy of pyloric duplication cysts
No full textThe Authors describe the laparoscopic treatment of a pediatric patient with a pyloric duplication cys
Classical lobular breast carcinoma consistently lacks topoisomerase-IIa gene amplification: implications for the tailored use of anthracycline-based chemotherapies
No full textAims: There is consistent lack of data focusing the topoisomerase-IIα gene status in lobular breast carcinoma, a subtype that usually shows poor responsiveness to chemotherapies including those using anthracycline drugs. Methods and results: Forty-six infiltrative lobular carcinomas, 13 with matched metastases, were used. Topoisomerase-IIα gene amplification was evaluated by chromogenic in situ hybridization (CISH) and fluorescence in situ hybridization (FISH). We also assessed Her2/neu status by CISH, FISH and silver in situ hybridization (SISH). HER2 immunoexpression was assessed by the HercepTest. Forty-four of 46 (95%) cases revealed no topoisomerase-IIα amplification, whereas two of 46 (5%) cases were amplified by all three techniques. Eleven of the 13 metastatic sites showed no amplification either in the primary or in the metastases (85%); the remaining two were amplified (15%). Her2/neu was not amplified in 44 of 46 (95%) cases nor was it amplified in 11 of 13 (95%) metastatic tissues. The two cases showing Her2/neu and topoisomerase-IIα amplification scored 3+; the remaining non-amplified cases scored 0 or 1+ in 40 and 2+ in four cases. Conclusions: In the era of personalized and tailored therapies, we suggest that patients affected by the classical lobular subtype of breast carcinoma constantly lack the ad hoc predictive rationale for receiving common chemotherapy that includes anthracyclines. © 2011 Blackwell Publishing Limited
Rhinitis in pre-school children: prevalence, association with allergic diseases and risk factors.
No full textBACKGROUND: The aim of our study was to assess the prevalence of rhinitis,
sneezing, runny or blocked nose apart from colds in a pre-school children
population and to evaluate the risk factors and relationship with allergic
diseases and sensitization.
METHODS: Eighteen nursery schools were randomly selected. The International Study
of Asthma and Allergies in Childhood (ISAAC) written questionnaire (WQ) was
distributed and filled by parents of pre-school children (3-5 years). The
allergic sensitization to common aeroallergens and foods was evaluated by skin
prick test (SPT). chi2 tests were used to compare proportions between rhinitic
and non-rhinitic children.
RESULTS: One thousand four hundred and two (92%) valuable questionnaires were
returned. Prevalence of rhinitis in the last 12 months was 16.8%. Rhinitic
children compared to non-rhinitic children presented a significant increase of
diagnosed asthma (20.8% vs. 6.2%, P<0.001), lifetime wheezing (43.2% vs. 21.6%,
P<0.001), wheezing in the last 12 months (25.0% vs. 9.4%, P<0.001), atopic
dermatitis (22.9% vs. 13.9%, P<0.001) and allergic sensitization (29.9% vs.
13.7%, P<0.001). Sensitization to grass pollen and house dust mites were
significant risk factors for rhinitis (P<0.01). A family history of atopy, having
pets at home, male gender and greater age were significant risk factors for
rhinitis, but not smoking exposure, sharing a bedroom or breastfeeding.
CONCLUSIONS: In pre-school children rhinitis has a strong association with
wheezing symptoms, asthma and atopic dermatitis. Allergic sensitization is a risk
factor for rhinitis and should be evaluated even in pre-school children
