1,721,023 research outputs found
The Establishment Of Callus And Cell Suspension Culture Of Sabah Snake Grass (Clinacanthus Nutans (Burm. F.) Lindau)
Get PDFClinacanthus nutans (Burm. f.) Lindau ialah sejenis tumbuhan ubatan dari famili Acanthaceae. Ia digunakan secara meluas untuk merawat radang kulit, luka kulit, jangkitan virus dan gigitan ula
Bioassays activity and FT-IR analysis of clinacanthus nutans (Burm F.) lindau leaves extracts
Get PDFObjectives: The present study was designed to investigate the antidiabetic and antioxidant activities of the different solvents extracts of Clinacanthus nutans (Burm. F) Lindau leaves through different bioassays as well as to identify the functional group(s) responsible for the particular bioactivity through Fourier transform infrared (FT-IR) spectroscopy.
Design and method: Mature leaves of C. nutans were collected, oven dried at 40 °C, powdered, and extracted in 80% hydro-methanol to obtain crude extract. This extract was then subjected to liquid to liquid partition to obtain hexane, ethyl acetate, butanol and aqueous extracts. All the extracts were then analysed for their bioactivity through various bioassays which include anti-oxidant (DPPH and FRAP) assay, xanthine oxidase and α-glucosidase inhibitory assays. FTIR analyses for the qualitative identification of bioactive compounds was then carried out to all the extracts.
Results: Bioactivity analyses of the plant’s leaves extracts on anti-oxidant (DPPH and FRAP) assay, xanthine oxidase and α-glucosidase inhibitory assays revealed that the hexane extract was highly active against α-glucosidase. Meanwhile ethyl acetate exhibited average activity in DPPH scavenging and xanthine oxidase inhibitory assays. Highest FRAP value was exhibited by ethyl acetate extract compared to others. Interestingly, FT-IR spectra analyses of each extract confirmed the presence of different functional groups that may have contributed to the various biological activity.
Conclusion: The results of the present study produced the FTIR spectrum profile for the vulnerable medicinally important plant C. nutans (Burm. F) Lindau that further confirms its medicinal values. Hence, C. nutans leaves extract is medicinally potent that may serve essentially in the development of new pharmaceuticals for natural plant-based medicine.
Keywords: Clinacanthus nutans (Burm. F) Lindau, DPPH, FRAP, xanthine oxidase, α-glucosidase, FTIR, active principle
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Clinacanthus nutans (Burm. f.) Lindau Ethanol Extract Inhibits Hepatoma in Mice through Upregulation of the Immune Response
No full textClinacanthans nutans (Burm. f.) Lindau is a popular medicinal vegetable in Southern Asia, and its extracts have displayed significant anti-proliferative effects on cancer cells in vitro. However, the underlying mechanism for this effect has yet to be established. This study investigated the antitumor and immunomodulatory activity of C. nutans (Burm. f.) Lindau 30% ethanol extract (CN30) in vivo. CN30 was prepared and its main components were identified using high-performance liquid chromatography (HPLC) and mass spectrometry (LC/MS/MS). CN30 had a significant inhibitory effect on tumor volume and weight. Hematoxylin and eosin (H & E) staining and TUNEL assay revealed that hepatoma cells underwent significant apoptosis with CN30 treatment, while expression levels of proliferation markers PCNA and p-AKT were significantly decreased when treated with low or high doses of CN30 treatment. Western blot analysis of PAPR, caspase-3, BAX, and Bcl2 also showed that CN30 induced apoptosis in hepatoma cells. Furthermore, intracellular staining analysis showed that CN30 treatment increased the number of IFN-γ+ T cells and decreased the number of IL-4+ T cells. Serum IFN-γ and interleukin-2 levels also significantly improved. Our findings indicated that CN30 demonstrated antitumor properties by up-regulating the immune response, and warrants further evaluation as a potential therapeutic agent for the treatment and prevention of cancers
Antiviral and Immunomodulatory Activities of Clinacanthus nutans (Burm. f.) Lindau
No full textClinacanthus nutans (Burm. f.) Lindau has been used as a traditional herbal medicine for treating snake bites, scalds, burns, and viral and bacterial infections. It has been attracting an increasing amount of attention because of its biological activities, including its antidiabetic, antioxidant, antibacterial, anticancer, anti-inflammatory, antiviral, and immunoregulatory activities. Here, we conducted a panoramic survey of the literature regarding the immunoregulatory, anti-inflammatory, and antiviral activities of C. nutans. We discovered that C. nutans extracts have virucidal activities against herpes simplex virus types 1 and 2, varicella-zoster virus, cyprinid herpesvirus 3, porcine reproductive and respiratory syndrome virus, mosquito-borne chikungunya virus, and potentially SARS-CoV-2; such activities likely result from C. nutans interfering with the entry, penetration, infection, and replication of viruses. We also reviewed the phytochemicals in C. nutans extracts that exhibit anti-inflammatory and immunoregulatory activities. This updated review of the antiviral, anti-inflammatory, and immunoregulatory activities of C. nutans may guide future agricultural practices and reveal clinical applications of C. nutans
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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