191 research outputs found
"E tutto doveva essere fedelmente rappresentato secondo l'arte della caccia". Il paesaggio dei Siti Reali
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How i treat malignant pleural mesothelioma
No full textMalignant pleural mesothelioma is a rare and aggressive malignancy mostly associated with occupational asbestos exposure. Prognosis is poor and only highly selected patients may benefit from aggressive surgical management, also as part of a multimodal approach. In advanced disease, the combination of pemetrexed and platinum remains the only established treatment, while efficacy evidence of second line chemotherapy is lacking. Thus, a deeper knowledge of biology of the disease and more effective treatments are urgently needed. Refer to specialised centres with multidisciplinary expertise is mandatory, as well as inclusion of patients in clinical trials is advisable whenever possible. In all stages of disease focus on symptoms control is paramount
51PD Effect of MEK inhibition on PDL1 and and on cytokinesproduction profilein NSCLC cell lines and in human lymphocites
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Le feste religiose e la lettura di un nuovo paesaggio precidano
No full textIl patrimonio sacro dell’isola di Procida è di grande valore e le processioni ne rappresentano una parte di estrema significanza, oltre le architetture, le edicole, gli oggetti sacri – tutti di inestimabile valore – i tratti disegnati dai percorsi processionali lasciano una traccia impalpabile quanto resistente che, come dimostra questo lavoro, è ancora possibile ricostruire. Il paesaggio dell’isola che si disvela attraverso i percorsi processionali è un paesaggio diverso, inedito, sono itinerari che non verrebbero naturali a colui il quale vuole scoprire l’isola. Il paesaggio culturale legato alle processioni è profondo e ormai stratificato, fa parte dell’identità dell’isola come della narrazione che di essa si f
The AGILE Silicon Tracker: an innovative gamma-ray instrument for space
No full textAGILE (Light Imager for Gamma-ray Astrophysics) is the first small scientific mission of ASI, the Italian Space Agency. It is a light (100 kg for the scientific instrument) satellite for the detection of gamma-ray sources in the energy range 30 MeV-50 GeV within a large field of view (1 of the sky). It is planned to be operational in the years 2003-2006, a period in which no other gamma-ray mission in the same energy range is foreseen.
AGILE is made of a silicon tungsten tracker, a CsI(Tl) minicalorimeter (1.5X(0)), an anticoincidence system of segmented plastic scintillators and a X-ray imaging detector sensitive in the 10-40 keV range. The tracker consists of 14 planes, each of them made of two layers of 16 single-sided, AC coupled, 410 mum thick, 9.5 x 9.5 cm(2) silicon detectors with a readout pitch of 242 mum and a floating strip. The readout ASIC is the TAA1, an analog-digital, low noise, self-triggering ASIC used in a very low power configuration (<400 μW/channel) with full analog readout. The trigger of the satellite is given by the tracker. The total number of readout channels is around 43 000.
We present a detailed description of the tracker, its trigger and readout logic, its assembly procedures and the prototype performance in several testbeam periods at the CERN PS
The AGILE Silicon Tracker: testbeam results of the prototype silicon detector
No full textAGILE (Light Imager for Gamma-ray Astrophysics) is a small scientific satellite for the detection of cosmic gamma-ray sources in the energy range 30 MeV-50 GeV with a very large field of view (1/4 of the sky). It is planned to be operational in the years 2003-2006, a period in which no other gamma-ray mission in the same energy range is foreseen.
The heart of the AGILE scientific instrument is a silicon-tungsten tracker made of 14 planes of single sided silicon detectors for a total of 43 000 readout channels. Each detector has a dimension of 9 5 x 9 5 cm(2) and a thickness of 410 mum.
We present here a detailed description of the performance of the detector prototype during a testbeam period at the CERN PS in May 2000. The Tracker performance is described in terms of position resolution and signal-to-noise ratio for on and off-axis incident charged particles. The measured 40 pm resolution for a large range of incident angles will provide an excellent angular resolution for cosmic gamma-ray imaging
HGF/MET and the Immune System: Relevance for Cancer Immunotherapy
No full textAn overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) axis promotes tumorigenesis and tumor progression in various cancer types. Research data recently evidenced that HGF/MET signaling is also involved also in the immune response, mainly modulating dendritic cells functions. In general, the pathway seems to play an immunosuppressive role, thus hypothesizing that it could constitute a mechanism of primary and acquired resistance to cancer immunotherapy. Recently, some approaches are being developed, including drug design and cell therapy to combine MET and programmed cell death receptor-1 (PD-1)/programmed cell death receptor-ligand 1 (PD-L1) inhibition. This approach could represent a new weapon in cancer therapy in the future
AGILE silicon tracker: an advanced gamma- and x-ray detector for space
No full textpubblicato su Proceedings of SPI
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