1,720,959 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Varianti alleliche del gene notch3 in un paziente con sospetto cadasil
No full textL’arteriopatia cerebrale autosomica dominante con infarti subcorticali e leucoencefalopatia (CADASIL, MIM#125310) è la forma ereditaria più comune di arteriopatia sistemica non-amiloide. Può manifestarsi a partire dalla seconda decade di vita con attacchi ischemici subcorticali ricorrenti, decadimento cognitivo, alterazioni dell'umore, emicrania, estese lesioni della sostanza bianca evidenziabili alla risonanza magnetica per immagini (MRI) ed accumulo di granuli elettrondensi (GOM) nella tunica media delle arteriole.
CADASIL è causata da mutazioni nel gene Notch3, che determinano l’acquisto o la perdita di residui di cisteina, con conseguente alterazione strutturale della proteina prodotta. Poche informazioni si hanno invece sulle altre varianti missenso e sul loro ruolo nello sviluppo della malattia.
In questo studio vengono riferiti i risultati dell’indagine molecolare del gene Notch3 condotta sul DNA di una paziente di 38 anni, proveniente dal Congo, giunta alla nostra osservazione con storia di emicrania sin dall’adolescenza, episodi di offuscamento del visus e brevi parestesie in emisoma dx. Alla MRI risultavano lesioni sottocorticali bilaterali interpretate come esiti gliotici. Veniva formulato il sospetto diagnostico di CADASIL e richiesta l’analisi di mutazione del gene Notch3. L’analisi molecolare mediante sequenziamento diretto di tutti gli esoni del gene ha permesso di identificare due variazioni di sequenza, A1020P (c.3058G>C) e V1183M (c.35474G>A), rispettivamente negli esoni 19 e 22, domini 26 e 30 di EGFR (epidermal growth factor-like repeat).
Tali varianti non coinvolgono residui di cisteina e sono state classificate come polimorfismi, tuttavia dall’analisi mediante software predittivi (SIFT e POLYPHEN), V1183M risulta a probabile significato patogenetico e A1020P risulta tollerata. Attualmente ci sono dati controversi sul significato patogenetico delle varianti e ci sono pochi dati circa la correlazione genotipo-fenotipo. Non possiamo ritenere con certezza che queste due varianti siano causative della patologia, è possibile però che insieme possano avere un effetto additivo e dare origine a forme moderate di CADASIL. Ulteriori indagini sono necessarie per capire se alterazioni in altri geni possano contribuire al fenotipo clinico.The cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ( CADASIL , MIM # 125310 ) is the most common inherited form of systemic arterial disorder.
CADASIL is caused by mutations in the Notch3 gene, which lead to a gain or loss of cysteine residues, resulting in structural alteration of the protein produced. Little is known about other missense variants and their role in disease development.
This study reported the results of Notch3 gene in a patient of 38 years, from the Congo, with history of migraine since adolescence, incidents of blurring of vision and short paresthesia in emisoma dx.
Molecular analysis by direct sequencing of all exons of the gene has identified two sequence variations, A1020P ( c.3058G > C ) and V1183M ( c.35474G > A), exons 19 and 22 respectively, in domains 26 and 30 of EGFR (Epidermal Growth Factor -like Repeat). Currently there are controversial data on the significance of these pathogenic variants and there are few data about their genotype-phenotype correlation. We can not be certain that these two variants are causative of the disease, it is possible, however, that together may have an additive effect and result in moderate forms of CADASIL. Further investigations are needed to understand whether alterations in other genes may contribute to the clinical phenotype
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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