364 research outputs found
Spontaneous abortion in banded mongooses: electronic supplementary material to Inzani et al. from Spontaneous abortion as a response to the reproductive conflict in the banded mongoose
No full textSupplementary methods and discussion for Inzani et al. Spontaneous abortion in banded mongoos
Experimental Research on the aerodynamics of three-dimensional yacht sails
No full textThe Aeronautical Journa
Designing with post-human kinship. Outlining new human non-human collaborative approaches.
No full textTechnology has increasingly become embedded in everyday activities, an extension of the human body, identity, and abilities. Our relationship with technology is becoming more symbiotic, leading us to establish new intimate and affective relationships. Following feminist philosopher Donna Haraway’s concept of making kin (Haraway, 2016) with human and non-human creatures to 'rebuild' the world, the first part of the paper investigates the development of kinship between humans and technological artefacts, and how these relationships can become a key element for a posthuman approach to design, identifying posthuman entities and their network of interactions. Specifically, it reviews literature from Science and Technology Studies (STS), Multi-species ethnography, and Haraway’s works. These theories and theoretical models underpin new methodologies and practices in the field of design that are breaking out of the boundaries delineated by the human-centred design (HCD) perspective and are expanding the interest of design beyond humans, addressing the non-human entity as part of a complex network of actors that dialogue, co-evolve, and co-operate in the evolution of the social order and the world.
These transformations are challenging designers to question the centrality of humans (and of designers themselves) in the design methods, structures, and models, as well as focusing on how new artefacts will interact and relate with humans, the environment, and other non-humans. The second part explores the potential contribution of a posthuman-centred design approach in developing human-non-human collaboration with a focus on care environments, considered a frontier. The analysis of two exemplary cases in the evolving context of care practices identify the entanglements with assistive devices, the emergence of the hybrid combination of human-technology in the care settings, their engagement with the environment, and the consequences of this increased permeability of technologies in everyday life. Finally, by mapping the values of a design practice involving non-humans, the paper considers how posthuman kinship could be drawn upon to contribute to both design research and development of technological artefacts within healthcare and care practices, stimulating posthuman design-driven forms of social and technological innovation
Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group
No full textEndometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications of the proposed new histomolecular classification system for ECs. In view of the substantial genetic and morphological heterogeneity in ECs, both classical pthological parameters and molecular classifiers have to be integrated in the pathology report. This review will focus on the most commonly adopted immunohistochemical and molecular biomarkers in daily clinical characterization of EC, referring to the most recent published recommendations, guidelines, and expert opinions
Data supporting Marshall et al. (2017) in Ecology and Evolution
No full textThis data supports the following publication: Marshall HH, Vitikainen EIK, Mwanguhya F, Businge R, Kyabulima S, Hares MC, Inzani E, Kalema-Zikusosa G, Mwesige K, Nichols HJ, Sanderson JL and Cant MA (2017). Lifetime fitness consequences of early-life ecological hardship in a wild mammal population. Ecology and EvolutionSee read me.txt file for further information</div
Endometrial carcinoma with diffuse melanocytic differentiation: Clinicopathological and molecular analysis of a case with literature review and focus on differential diagnosis
No full textHerein, we present a clinicopathological and molecular analysis of a case of endometrial carcinoma with diffuse melanocytic differentiation with literature review. A 72-year-old woman underwent hysterectomy due to a 14 cm endometrial mass. On histology, the tumor showed a serous carcinoma component and a solid component with giant eosinophilic and dyshesive multinucleated cells. Differential diagnosis included several entities, such as undifferentiated giant cell carcinoma and carcinosarcoma with rhabdomyoblasts. The solid component showed diffuse positivity for cytokeratin AE1/AE3, Melan A, Cathepsin K and S100, focal HMB45 positivity and loss of e-cadherin. The tumor was p53-abnormal, mismatch repair-proficient and POLE-wild-type. The patient had extrauterine metastases and was alive with disease at 12 months. Previous cases of endometrial and ovarian carcinomas with melanocytic differentiation (n = 7) did not show giant bizarre cells but showed melanin production; all cases were advanced and/or had unfavorable outcomes. In conclusion, endometrial carcinomas with melanocytic differentiation are highly aggressive tumors which should be distinguished from other entities. Being aware of this entity may help not to miss it
Systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC): A case report of a multimodal treatment for peritoneal metastases of pancreatic origin
No full textIntroduction: Pancreatic ductal adenocarcinoma (PDAC) with peritoneal metastases (PM) has a dismal prognosis and palliative systemic chemotherapy, which represents the standard treatment option, has significant pharmacokinetics limitations and low efficacy. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new method of drug delivery that is expected to maximize exposure of peritoneal nodules to antiblastic agents. A combination of systemic chemotherapy and PIPAC may be valuable. Presentation of case: A 55 years old male affected by PDAC with synchronous PM underwent a multimodal treatment comprising systemic chemotherapy and PIPAC without any procedural-related adverse events. Tumor genomic profiling evaluation from peritoneal biopsies addressed further tailored systemic chemotherapy. Discussion: The presented case illustrates the possibility of adding PIPAC to systemic chemotherapy with a fair tolerance profile and good quality of life while allowing monitoring of therapy-response and tailoring of the antiblastic treatment
Cardiac stem cells can be isolated and characterized from 3d-electroanatomic guided endomyocardial biopsies in a preclinical animal model
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