587 research outputs found
F.-R. Trancheport : L'Opéra (t. I : D'Orfeo à Tristan ; t. II : De Tristan à nos jours), 1978
No full textEscudier Monique. F.-R. Trancheport : L'Opéra (t. I : D'Orfeo à Tristan ; t. II : De Tristan à nos jours), 1978. In: Dix-huitième Siècle, n°12, 1980. Représentations de la vie sexuelle. p. 580
L. F. H. Lefèbure : Bévues, erreurs et méprises de différents auteurs célèbres en matières musicales (Paris 1789) ; Boyé : L'expression musicale mise au rang des chimères (Amsterdam, 1779), 1973
No full textEscudier Monique. L. F. H. Lefèbure : Bévues, erreurs et méprises de différents auteurs célèbres en matières musicales (Paris 1789) ; Boyé : L'expression musicale mise au rang des chimères (Amsterdam, 1779), 1973. In: Dix-huitième Siècle, n°11, 1979. L'année 1778. pp. 458-459
Plan topographique du collège et de la ville de Sorèze / Mr Dèze de Grèzes, ingénieur géomètre de 1re classe ; Lithographie de Bonnal F[rè]res et Escudier
No full textÉchelle(s) : [ca 1:1 300], échelle de 300 mètres [= 23,3 cm]Appartient à l’ensemble documentaire : MidiPyren
La conscience historique déchirée des Modernes : perfectibilité (B. Constant) ; éducation esthétique (F. Schiller) ; théodicée (F. Schlegel)
No full textThe divided consciousness of the Modernes: perfectibility, aesthetic education, theodicy.B. Constant, F. Schiller and F. Schlegel were contemporaries who had met on occasion. Each writer developed an authentic philosophy of history whose themes can be summed up respectively as «perfectibility», «aesthetic education» and «anti-chiliastic theodicy». These three positions in no way coincide and typify the extreme heterogeneity of the historical thinking of the «Modernes». In this article the view which is put forward can be summarized thus: 1) each of these writers does indeed have a philosophy of history worthy of the name; 2) this philosophy has to be grasped and reconstructed in the light of their individual views about Modernity; 3) each writer constructs an articulated model of world history with an original mainspring, various stages in development and a normative end point; 4) each of these philosophies of history is closely linked to a more or less explicit political philosophy; 5) the problem of constitutionalism, to which only B. Constant’s work offers a precise response, is the criterion which enables us today to discriminate normatively between these three positions
Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome
No full textBackground: Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of a `tumor-associated' acute respiratory distress syndrome (ARDS) has been hypothesized. Case Report: We report the clinical course of a 19-year-old patient who rapidly developed fatal ARDS during the first cycle of chemotherapy using the PEI regimen (cisplatin, etoposide and ifosfamide) for a metastasized (lung, liver, lymph nodes) germ cell tumor of the testis. Conclusion: Further clinical research in order to better define risk factors for developing ARDS in this patient population as well as novel strategies for the prevention and treatment of ARDS in those patients are necessary
Evidence and Clinical Relevance of Tumor Flare in Patients Who Discontinue Tyrosine Kinase Inhibitors for Treatment of Metastatic Renal Cell Carcinoma.
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Evidence and clinical relevance of tumor flare in patients who discontinue tyrosine kinase inhibitors for treatment of metastatic renal cell carcinoma
No full textBackground: Several tyrosine kinase inhibitors (TKIs) and one monoclonal antibody targeting the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) axis have been approved for the treatment of metastatic renal cell carcinoma (mRCC). Preclinical data suggest that cessation of anti-VEGF therapy may generate a tumor flare (TF) but its clinical relevance is still questionable. Objective: This analysis investigates the occurrence of tumor flare and its prognostic role after discontinuation of anti-VEGFR TKIs in patients affected by mRCC. Design, setting, and participants: Patients with mRCC treated with first-line sunitinib or pazopanib at standard dosages were screened. Patients included in the analysis were required to have: (1) discontinued treatment because of progression of disease or intolerable toxicity or sustained response; (2) evaluation of tumor growth rates immediately before (GR1) and after discontinuation (GR2); and (3) no treatment during evaluation of GR2. Outcome measurements and statistical analysis: Overall survival (OS) was the main outcome. TF was calculated as the difference between the GR values (TF = GR2 GR1). Cox proportional hazards regression was used to assess the prognostic role. Results and limitations: Sixty-three consecutive patients were analyzed; the median duration of treatment was 9.3 mo, the median progression-free survival (PFS) was 11.1 mo, and the median OS was 41.5 mo. The reasons for treatment discontinuation were sustained response (partial response/stable disease) in 15.9%, toxicity in 22.2%, and progression of disease in 61.9% of cases. The median GR1 and GR2 were 0.16 cm/mo (interquartile range [IQR] 0.07 to 0.53) and 0.70 cm/mo (IQR 0.21-1.46), respectively ( p = 0.001). In the overall population, the median TF was 0.55 cm/mo (IQR 0.08-1.22) and differed according to the reason for discontinuation: 0.15 cm/mo for response, 0.95 cm/mo for toxicity, and 1.66 cm/mo for progression.When TFwas compared to other prognostic variables, Cox analysis confirmed its prognostic role (hazard ratio 1.11, 95% confidence interval 1.001-1.225; p = 0.048). Conclusions: This study reports clinical evidence that TKI discontinuation results in acceleration of tumor GR and induces TF, which can negatively affect the prognosis of mRCC patients. Patient summary: In this report, we looked at the outcomes for patients affected by metastatic kidney tumors who discontinued treatment with antiangiogenic agents. We found that tumor regrowth after discontinuation of therapy was related to the reason for discontinuation: regrowth was higher in patients who discontinued treatment because of disease progression, and lower in patients who discontinued treatment because of a sustained response. Moreover, we found that the higher the growth rate, the shorter the survival. We conclude that discontinuation of antiangiogenic agents may cause an increase in tumor growth rate, which is related to patient survival
Dictionnaire de musique théorique et historique / par les frères Escudier ; avec une préface de M. F. Halévy
No full textAvec mode text
Dictionnaire de musique théorique et historique / par les frères Escudier ; avec une préface de M. F. Halévy
No full textAvec mode text
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