1,613 research outputs found
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Letter to Albert F. Eble from H.B. Stenzel on 1964-05-01
No full textJackson School of Geoscience
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Letter to Albert F. Eble from H.B. Stenzel on 1964-04-22
No full textJackson School of Geoscience
OXYGEN-TENSION DISTRIBUTION IN HEAD AND NECK CARCINOMAS AFTER PERORAL OXYGEN-THERAPY
No full textBackground: It has been shown that the response on radiotherapy in human tumors is correlated to the oxygen supply. Polarographic needle electrodes offer a feasible tool to determine the oxygen tension distribution in human tumors. The peroral administration of oxygen-enhanced water may be able to overcome the radioresistance in reducing hypoxic regions in larger tumors and will be analyzed. Patients and Methods: Oxygen tension distributions were determined in clinically fixed lymph node metastases in 6 patients suffering from a carcinoma of the base of the tongue (n=2), larynx (n=2), hypopharynx and tonsillar fossa before and immediately after drinking oxygen-enhanced water (20 mg/l O-2) From a pooled histogram (n=200) median pO(2), mean pO(2) and hypoxic fraction could be calculated and compared. Results: The determined pO(2) tension values showed a typical distribution for squamous cell carcinomas of the head and neck region with the proof of containing hypoxic tumor cells. After administration of oxygen-enhanced water 2 patients revealed only a marginal increase in oxygen supply. A moderate improvement in tissue oxygenation was observed in 3 patients, combined with a therapeutically relevant shift of pO(2) values from the low pO(2) classes (<10 mm Hg) to medium pO(2) classes. In 1 patient an impressive increase in the overall oxygen tissue tension could be observed. The overall mean and median pO(2) values increased after peroral oxygen therapy (POT) from 14.4 to 23.3 mm Hg and from 22.3 to 30.2 mm Hg, respectively. The hypoxic fraction was significantly reduced. Conclusion: The peroral administration of oxygen-enhanced water is a feasible technique to increase the oxygen supply to tumors. The therapeutic role should be evaluated ina larger clinical trial, combined with the invasive determination of oxygen tension distributions. The reduced hypoxic fraction seems to be promising in therapeutic irradiation
Book Review: Interrogating Gendered Pathologies, Edited by Erin A. Frost & Michelle F. Eble
No full textBook Review: Interrogating Gendered Pathologies. Erin A. Frost & Michelle F. Eble, Eds. Louisville, CO: University Press of Colorado, 2020. 279 pages, 28.95 e-book, $14.50 30-day e-book rental.
Publisher webpage: https://upcolorado.com/utah-state-university-press/item/3819-interrogating-gendered-pathologies
Review by Julie Gerdes, Department of English, Virginia Tech, Blacksburg, VA
E-mail: [email protected]
Date Posted: June 2023
Recommended Citation: Gerdes, Julia. (2023) “Book review: Interrogating Gendered Pathologies,” Rhetoric of Health & Medicine: Vol. 6: Iss. 3
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Letter to H.B. Stenzel from Albert F. Eble on 1964-04-27
No full textJackson School of Geoscience
Das Evaluationskonzept im Antrag
No full textDörries M, Leppert F, Greiner W. Das Evaluationskonzept im Antrag. In: Amelung VE, Eble S, Hildebrandt H, et al., eds. Innovationsfonds - Impulse für das deutsche Gesundheitssystem. 1st ed. Berlin: MWV Medizinisch Wissenschaftliche Verlagsgesellschaft; 2017: 109-116
Mixed Epithelial and Stromal Tumor of the Kidney: A Clinicopathologic Study of 53 Cases
No full textMixed epithelial and stromal tumor of the kidney is an uncommon complex neoplasm, and previous studies have included only a modest number of cases and have left gaps in our understanding of its morphology. We analyzed 53 tumors (46 F, median age: 49 y), collecting data on gross, histologic, and immunohistochemical features. The most common gross appearance was solid and cystic (47%). Hypocellular fibrous and cellular spindle cell stroma were the most common stromal types, followed by smooth muscle differentiation, edematous stroma, and adipose tissue. Hypocellular fibrous stroma and adipose tissue were more common in larger tumors (P=0.003 and 0.04, respectively) and cellular spindle cell stroma in smaller tumors (P=0.0009). Combinations of diverse stromal elements were common: roughly 50% of tumors contained >4 types of stroma. With regard to epithelium, tiny crowded and branching glands were present in 60% of tumors. Round glands lined by tall cuboidal epithelium, reminiscent of thyroid follicles, spatulate papillae reminiscent of phyllodes tumor, glands reminiscent of nephrogenic adenoma, and complex papillae were also frequently found. Combinations of diverse epithelial elements were common: 64% of tumors contained >4 types of epithelium. All of the tumors except 1 were positive for smooth muscle actin in the stroma. Desmin and caldesmon expression were more variable. Stains for progesterone and estrogen receptors showed positivity in the stromal component in 85% and 73% of tumors, respectively. CD10 and CD34 immunolabeling were restricted to pericystic spindle cells. No tumor expressed inhibin. In summary, this study demonstrates a strong tendency for mixed epithelial and stromal tumors to contain multiple types of stroma and epithelium and comprehensively analyzes the immunohistochemical profile
Neoplasie epiteliali eosinofile del rene: utilità della ibridizzazione in situ fluorescente (FISH) nella diagnosi differenziale
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