180 research outputs found
Activating new compaies networks where new flows of material generate internal connections
No full textCurrent evidence linking diet to gut microbiota and brain development and function
No full textThe gut:brain axis is emerging as an important information highway linking the foods we eat with neurophysiological development and functions. Some gut microorganisms have shown to alleviate anxiety and depression, improve cognitive performance and play a role in brain development in early life. However, most studies were conducted in laboratory animals and these findings await confirmation in carefully designed human interventions. Similarly, little attention has been given to how diet:microbe interactions within the gut can impact on neurotransmitter production or their subsequent biological effects within the nervous system. In this review, we discuss the possible influence of carbohydrates, polyphenols, lipids and proteins colonic fermentation on production, bioavailability and biological activity of metabolites linked to the gut-microbiota-brain axis. An increased understanding of how nervous system may be regulated by diet will greatly enhance our ability to design dietary strategies to improve healthy brain development and functions
Cytocompatiobility studies within MINERVA: MIcrobiota-Gut-BraiN EngineeRed platform to eVAluate intestinal microflora impact on brain functionality
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Pengaruh Aksesibilitas Dan Citra Destinasi Terhadap Minat Berkunjung Kembali Wisatawan Domestik Pada Objek Wisata Way Tebing Ceppa Taman Baru Penengahan Lampung Selatan
No full textDi era masa kini pariwisata menjadi salah satu sektor penting dalam mendukung perekonomian Negara Indonesia, dengan keindahan alam serta kekayaan budaya Indonesia menjadi Negara dengan potensi wisata yang sangat baik. Objek wisata Way Tebing Ceppa merupakan salah satu objek wisata yang berada di Kabupaten Lampung Selatan. Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh antara Variabel Aksesibilitas dan Variabel Citra Destinasi terhadap Variabel Minat Berkunjung Kembali Wisatawan Domestik pada objek wisata Way Tebing Ceppa Taman Baru Penengahan Lampung Selatan baik secara parsial maupun simultan. Teknik pengambilan sampel menggunakan metode Non-Probability Sampling, jenis data yang digunakan yaitu berupa kuesioner (angket). Populasi pada penelitian ini adalah jumlah pengunjung objek wisata Way Tebing Ceppapada tahun 2024. dengan jumlah sampel 100 responden. Metode penelitian yang digunakan adalah metode penelitian Kuantitatif. Analisis data menggunakan analisis regresi linier berganda, uji t, uji f, uji koefisien korelasi danuji koefisien determinasi dengan aplikasi SPSS 26. Hasil penelitian ini menunjukanbahwa Variabel Aksesibilitas memiliki pengaruh positif dan signifikan terhadap Variabel Minat Berkunjung Kembali Wisatawan Domestik pada objek wisata Way Tebing Ceppa Taman Baru Penengahan Lampung Selatan, sedangkan Variabel Citra Destinasi tidak berpengaruh terhadap Variabel Minat Berkunjung Kembali Wisatawan Domestik pada objek wisata Way Tebing Ceppa Taman Baru Penengahan Lampung Selatan. Variabel Aksesibilitas dan Variabel Citra Destinasi secarabersama-sama memilikipengaruhpositif dan signifikan terhadap Variabel Minat Berkunjung Kembali wisatawan domestik. Kata Kunci: Aksesibilitas, Citra Destinasi, Minat Berkunjung Kembal
Passata di pomodoro authenticity checks using δ18O analysis
No full textTomato puree (passata di pomodoro) represents a classic and emblematic Italian product around the world and is of considerable importance for the Italian economy. It has recently been estimated that 15% of industrial tomato comes from China in paste form (http://affaritaliani.libero.it/green/coldiretti_pomodoro_cina280311.html). For these reasons Italian law (Ministerial Decree of 23
September 2005) provides a very strict definition of ‘passata di pomodoro’ and establishes that the use of tomato concentrates over 12° degrees Brix and subsequent dilution to obtain ‘reconstituted passata’ is not permitted. Furthermore it indicates δ18O measurement in vegetal water (UNI ENV 12141 method) as the official method for detecting fraudulent dilution, but does not report any reference values for authentic passata. Trifirò et al. (2007) verified that passata effectively shows δ18O values significantly higher than products obtained by diluting tomato paste and proposed a minimum threshold value of -1.6‰ for authentic passata with Brix values between 7.5 and 10°. In this work we analysed authentic samples of passata, paste and diluted concentrate in order to check the validity of this threshold value and to establish a 18O limit value for passata produced by diluting products with a Brix
value lower than 12°. A large number of samples of Italian ‘passata di pomodoro’ and paste from Italy, Greece, Turkey and China
have been officially collected by the Italian Ministry of Agricultural, Food and Forestry Policy since 2009. Analysis of the δ18O of vegetal water was performed on these samples using an Isotope Ratio Mass Spectrometer (IRMS), interfaced with a CO2
equilibration system, according to the ENV 12141 method. The results essentially confirmed that -1.6‰ can be considered as the
limit 18O value for authentic passata with a Brix of over 7.5°. Furthermore a δ18O of -2.5‰ can be considered as a limit value for
passata coming from the dilution of products with a Brix level of less than 12°. All the diluted pastes showed δ18O values far below
these limits. This research was funded by the Italian Ministry of Agricultural, Food and Forestry Policy
Development of chromatographic methods for the determination of genotoxic impurities in cloperastine fendizoate
No full textThe classification of an impurity of a drug substance as genotoxic means that the “threshold of toxicological concern” (TTC) value of 1.5 ug/day intake, considered to be associated with an acceptable risk, should be the admissible limit in the raw material and that leads to new analytical challenges. In this study, reliable chromatographic methods were developed and applied as limit tests for the control of three genotoxic impurities (GTIs) in cloperastine fendizoate, drug widely used as an antitussive active pharmaceutical ingredient (API). In particular, GC–MS was applied to the determination of one alkyl halide (2-chloroethanol, 2-CE), while HPLC-DAD was selected for the analysis of two sulfonate esters (methyl p-toluenesulfonate, MPTS, and 2-chloroethyl p-toluenesulfonate, CEPTS).Regarding GC–MS, strong anion-exchange (SAX)-SPE was applied to remove fendizoate from the sample solutions, due its low volatility and its high amount in the raw material. The GC–MS analysis was performed on a Factor Four VF-23ms capillary column (30 m × 0.25 mm I.D., film thickness 0.25 um, Varian). Single ion-monitoring (SIM) detection mode was set at m/z 80.In the case of HPLC-DAD, a suitable optimization of the chromatographic conditions was carried out in order to obtain a good separation of the impurity peaks from the drug substance peaks. The optimized method utilizes a SymmetryShield RP8 column (250 mm × 4.6 mm, 5 um, Waters) kept at 50 ◦C, withphosphate buffer (pH 3.0; 10 mM)–methanol (containing 10% ACN) (45:55, v/v) as the mobile phase, at the flow-rate of 1.7 mL/min and UV detection at 227 nm. The required sensitivity level was achieved by injecting 80 uL of sample solution, purified from fendizoate by SAX-SPE, followed by a 1:1 (v/v) dilutionof the SPE eluate with water.For both GC–MS and HPLC-DAD, the method validation was performed in relation to specificity and limit of detection (LOD), as required by ICH guidelines in relation to limit assays. The developed methods were successfully applied for the determination of GTIs in five different batches of cloperastine fendizoate. In all the analyzed batches, the three target GTIs were below the concentration limit
Pseudotumor of the liver: A challenging diagnosis
No full textInflammatory pseudotumors of the liver are rare, and their natural history is mostly unknown. Making the diagnosis is often difficult, and these masses are often confused with other lesions, generally either primary or secondary neoplasms. The case of a patient who had an exhaustive preoperative work-up, including ultrasonography, CT scan and MRI, is herein presented. The characteristics of each exam, particularly those of the MRI, in which the pattern is poorly described in the literature, are reported. A fine needle biopsy was not contributive, as it was performed too centrally within the nodule. Only a high degree of suspicion and the existence of this tumor might lead to a preoperative diagnosis, thus avoiding major surgery. However, as is evident from the experiences of most authors and from our own, doubt may persist even after an exhaustive work-up. Since the morbidity and mortality of liver resection of noncirrhotic livers is low, surgery should be considered the treatment of choice
Malignant Tumors in the Head of the Pancreas and the Periampullary Region. Diagnostic and Prognostic Aspects.
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