135 research outputs found
L'abate Luigi Antonio Lanzi tra filologia classica e letteratura religiosa
No full textIntento del convegno è stato recuperare aspetti della vita e dell’opera di Luigi Lanzi (1732-1810) ad oggi poco noti, se non del tutto trascurati, dalla critica, eppure niente affatto superflui o secondari nell’offrire ulteriori spunti di comprensione e valutazione dello studioso e dell’opera sua tutta, compresa quella di antiquaria e di storia dell’arte, meglio discussa finora. Si è ritenuto opportuno ripartire pertanto dalla formazione di Lanzi, contestualizzata e puntualizzata in quell’itinerario spirituale e scientifico che da Fermo giunge al Collegio Romano (manca tuttora una vera e propria biografia del personaggio, salvo quelle ottocentesche - di prima mano, ma datate - di Onofrio e di Mauro Boni e di Fortunato Benigni). Al pari, è stata proposta, per la prima volta, l’analisi dei suoi scritti –editi o solo preparati per la pubblicazione – a carattere devozionale e filologico-letterario, in specie di ambito classico. Sono intervenuti: Angelo Bianchi (Università Cattolica di Milano), Robert Danieluk (Archivum Romanum Societatis Iesu), Flavio Rurale (Università di Udine), Fernando J. de Lasala (Pontificia Università Gregoriana, Roma), Fabrizio Capanni (Pontificia Commissione per i Beni Culturali della Chiesa), Gianni Festa (Facoltà Teologica dell’Emilia Romagna, Bologna), Giulia Pedace (Università di Roma ‘La Sapienza’), Francesca Martina Falchi (Università di Urbino), Paolo Fedeli (Università di Bari), Sotera Fornaro (Università di Sassari), Marco Buonocore (Biblioteca Apostolica Vaticana); hanno presieduto i lavori: Giovanna Perini, Renato Raffaelli, Guido Arbizzoni Artusi, Anna Santucci (Università di Urbino)
L'abate Luigi Antonio Lanzi tra filologia classica e letteratura religiosa, Atti della giornata di studi, Corridonia (MC) 14 novembre 2009
No full textLuigi Lanzi (1732-1810) è tra le più eminenti personalità della cultura tardo-settecentesca. Gesuita di formazione, fu Regio Antiquario della Galleria degli Uffizi di Firenze per volontà di Pietro Leopoldo, Granduca di Toscana; fu filologo e, soprattutto, pionieristico studioso della Storia dell’arte e dell’Etruscologia. Ormai ottuagenario venne nominato Presidente dell’Accademia della Crusca; è sepolto in Santa Croce a Firenze. Il convegno, organizzato nell'ambito delle celebrazioni per il bicentenario della morte, offre un'accurata ricostruzione della sua vicenda biografica - nel relativo contesto storico, politico e culturale - ed affronta aspetti della sua vasta opera finora poco indagati: le edizioni critiche di autori greci e latini e gli scritti devozional
NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation.
No full textAs only 60% of leukaemia patients find a matched donor, the Perugia Bone Marrow Transplant Centre developed transplantation from HLA haplotype-mismatched family donors to provide a cure for more patients [F. Aversa, A. Tabilio, A. Terenzi, et al., Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum, Blood 84 (1994) 3948-3955] [F. Aversa, A. Tabilio, A. Velardi, et al., Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype, N. Engl. J. Med. 339 (1998) 1186-1193] [F. Aversa, A. Terenzi, A. Tabilio, et al., Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse, J. Clin. Oncol. 23 (2005) 3447-3454]. HLA-mismatches trigger donor vs. recipient NK cell alloreactivity which improves engraftment, protects from GvHD and reduces relapse in AML patients [L. Ruggeri, M. Capanni, E. Urbani, et al., Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants, Science 295 (2002) 2097-2100], [L. Ruggeri, A. Mancusi, M. Capanni, E. Urbani, A. Carotti, T. Aloisi, M. Stern, D. Pende, K. Perruccio, E. Burchielli, F. Topini, E. Bianchi, F. Aversa, M.F. Martelli, A. Velardi, Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value, Blood, in press]. We are using murine transplant models to determine whether NK cell alloreactivity can be exploited to reduce transplant-related mortality (TRM) which remains a major issue. Data from these on-going studies show pre-transplant infusion of alloreactive NK cells: (1) ablates AML cells, (2) kills recipient T cells, permitting a reduced toxicity conditioning regimen, and (3) ablates the recipient dendritic cells (DCs) which trigger GvHD, thus protecting from GvHD while permitting a higher T cell content in the graft. We are designing a clinical haploidentical transplant trial using alloreactive NK cells in the conditioning regimen, with the aim of reducing TRM and improving outcomes and overall survival
Statistica e tossicologia: l’importanza della interdisciplinarietà per valutare il pericolo potenziale da organoclorurati nella stenella striata (Stenella coeruleoalba) del Mar Mediterraneo
No full text
Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
No full textBackground: To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion. Case presentation: A 72-year-old woman presents with constipation. Colonoscopy reveals a sessile polypoid lesion of the colon bearing morphological, immunohistochemical and molecular hallmarks of DH-FL. Complete clinical staging and bone marrow biopsy showed no signs of disseminated disease. The patient, after two years of follow-up is still free of disease confirming the indolent behaviour of this limited lesion. Conclusions: A synoptic view at all the features of the patient and not merely at the molecular hallmarks of a disease are essential to establish the correct clinical approach
STUDYING THE FOLDING PROCESS OF THE ACYLPHOSPHATASE FROM SULFOLOBUS SOLFATARICUS. A COMPARATIVE ANALYSIS WITH OTHER PROTEINS FROM THE SAME SUPERFAMILY
No full textThe folding process of the acylphosphatase from Sulfolobus solfataricus (Sso AcP) has been followed, starting from the fully unfolded state, using a variety of spectroscopic probes, including intrinsic fluorescence, circular dichroism, and ANS binding. The results indicate that an ensemble of partially folded or misfolded species form rapidly on the submillisecond time scale after initiation of folding. This conformational ensemble produces a pronounced downward curvature in the Chevron plot, appears to possess a content of secondary structure similar to that of the native state, as revealed by far-UV circular dichroism, and appears to have surface-exposed hydrophobic clusters, as indicated by the ability of this ensemble to bind to 8-anilino-1-naphthalenesulfonic acid (ANS). Sso AcP folds from this conformational state with a rate constant of ca. 5 s(-1) at pH 5.5 and 37 degrees C. A minor slow exponential phase detected during folding (rate constant of 0.2 s(-1) under these conditions) is accelerated by cyclophilin A and is absent in a mutant of Sso AcP in which alanine replaces the proline residue at position 50. This indicates that for a lower fraction of Sso AcP molecules the folding process is rate-limited by the cis-trans isomerism of the peptide bond preceding Pro50. A comparative analysis with four other homologous proteins from the acylphosphatase superfamily shows that sequence hydrophobicity is an important determinant of the conformational stability of partially folded states that may accumulate during folding of a protein. A low net charge and a high propensity to form alpha-helical structure also emerge as possibly important determinants of the stability of partially folded states. A significant correlation is also observed between folding rate and hydrophobic content of the sequence within this superfamily, lending support to the idea that sequence hydrophobicity, in addition to relative contact order and conformational stability of the native state, is a key determinant of folding rate
How significantly do human interactions impact cetacean strandings? A comprehensive analysis over the years of data collection in the Italian National Stranding Data Bank
No full textA mitigation approach to reduce dolphin-fishery interaction using acoustic deterrent device on trammel nets in the Northern Tyrrhenian Sea (Tuscany, Italy)
No full textOrally administered nano-polystyrene caused vitellogenin alteration and oxidative stress in the Red Swamp Crayfish (Procambarus clarkii)
No full textNanoplastics (≤100 nm) represent the smallest fraction of plastic litter and may result in the aquatic environment as degradation products of larger plastic material. To date, few studies focused on the interactions of micro- and nanoplastics with freshwater Decapoda. The red swamp crayfish (Procambarus clarkii, Girard, 1852) is an invasive species able to tolerate highly perturbed environments. As a benthic opportunistic feeder, this species may be susceptible to plastic ingestion. In this study, adult P. clarkii, at intermolt stage, were exposed to 100 μg of 100 nm carboxylated polystyrene nanoparticles (PS NPs) through diet in a 72h acute toxicity test. An integrated approach was conceived to assess the biological effects of PS NPs, by analyzing both transcriptomic and physiological responses. Total hemocyte counts, basal and total phenoloxidase activities, glycemia and total protein concentration were investigated in crayfish hemolymph at 0h, 24h, 48h and 72h from PS NPs administration to evaluate general stress response over time. Differentially expressed genes (DEGs) in the hemocytes and hepatopancreas were
analyzed to ascertain the response of crayfish to PS NP challenge after 72h. At a physiological level, crayfish were able to compensate for the induced stress, not exceeding generic stress thresholds. The RNA-Sequencing analysis revealed the altered expression of few genes involved in immune response, oxidative stress, gene transcription and translation, protein degradation, lipid metabolism, oxygen demand, and reproduction after PS NPs exposure. This study suggests that a low concentration of PS NPs may induce mild stress in crayfish, and sheds light on molecular pathways possibly involved in nanoplastic toxicity
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