292 research outputs found
THE RADIOLOGICAL, CLINICAL AND FUNCTIONAL PROPERTIES OF HAND OSTEOARTHRITIS AND THEIR RELATION WITH RADIOLOGICAL FINDINGS IN A TURKISH POPULATION: TLAR-OA STUDY
No full textCongress of the European-League-Against-Rheumatism (EULAR) -- JUN 13-16, 2018 -- Amsterdam, NETHERLANDS…European League Against RheumatismABVIEM. T. Duruoz Grant/research support from: ABVIE, Consultant for: NOVARTIS, Speakers bureau: ABDI IBRAHIM, D. Erdem: None declared, T. Tuncer: None declared, L. Altan: None declared, F. Ayhan: None declared, A. Bal: None declared, L. Cerrahoglu: None declared, E. Capkin: None declared, R. Cevik: None declared, D. Dulgeroglu: None declared, S. Gursoy: None declared, S. Hizmetli: None declared, C. Kacar: None declared, E. Kaptanoglu: None declared, T. Kaya: None declared, H. Kocabas: None declared, K. Nas: None declared, S. Ozcakir: None declared, D. Sindel: None declared, O. Sahin: None declared, G. Tasci Bozbas: None declared, C. Tikiz: None declared, H. Ugurlu: None declare
First record of phyllorhiza punctata von lendenfeld, 1884 (Scyphozoa: Rhizostomeae: Mastigiidae) from Turkey
No full textThe Australian spotted jellyfish Phyllorhiza punctata has been reported from several locations in the Mediterranean, but the present report is the first record from Turkish waters. Juveniles of the Erythrean alien shrimp scad, Alepes djedaba, were observed nestling among its tentacles. Possible vectors are mentioned. © 2011 The Author(s)
Fixed dose darunavir boosted with cobicistat combined with emtricitabine and tenofovir alafenamide fumarate
No full textPurpose of review: In an era when virological efficacy approaches 100%, novel antiretroviral (ARV) therapies must deliver better tolerability, safety, and convenient coformulated regimens. We review the phase II and III clinical data on the fixed dose combination (FDC) darunavir (DRV) 800mg / cobicistat (COBI/C) 150 mg / emtricitabine (F/FTC) 200 mg / tenofovir alafenamide fumarate (TAF) 10mg (D/C/F/TAF) for the treatment of HIV-1 infection.Recent finding: In an exploratory phase II study, D/C/F/TAF FDC demonstrated similar virological efficacy to darunavir/cobicistat FDC + F /tenofovir disoproxil fumarate (TDF) FDC in treatment-naive HIV-1-infected individuals with favorable bone and renal outcomes. These findings led to two subsequent international phase III double-blind randomized controlled trials; AMBER and EMERALD. In the (treatment naïve) AMBER study, D/C/F/TAF FDC was noninferior to component regimen F/TDF + darunavir/cobicistat with favorable bone and renal outcomes at week 48. In the EMERALD study (switch study for virologically suppressed patients), D/C/F/TAF showed noninferior efficacy to F/TDF and boosted protease inhibitor (bPI) regimen at week 48 also with favorable renal and bone outcomes. No virological failure was observed, and no resistance to TDF or darunavir emerged in either study.Summary: In clinical trials, D/C/F/TAF FDC demonstrated excellent, noninferior virological efficacy, maintained a high genetic barrier and conferred the additional safety benefits of TAF. As the first one pill, once daily, protease inhibitor-based regimen, D/C/F/TAF FDC offers a new option for the treatment of HIV infection.</p
Stability-indicating high performance thin layer chromatographic determination of sulfanilamide in human urine
No full textA simple, sensitive, selective, precise and stability-indicating high-performance thin-layer chromatographic (HPTLC) method was developed and applied to human urine for the densitometric determination of sulfanilamide. A mixture of chloroform-ethyl acetate-xylene (2.5: 4.0: 1.0, v/v/v) was used as a mobile phase. The system was found to give compact spots for sulfanilamide (retardation factor, R (f) = 0.21 +/- 0.02). The linear regression analysis data for the calibration plots showed good linear relationship with r (2) = 0.9970 +/- 0.0003 and r (2) = 0.9947 +/- 0.020 within the concentration range of 50-250 ng per spot and 100-1000 ng per spot with respect to peak area, respectively. The limit of detection (LOD) and quantification (LOQ) were 8 and 25 ng per spot, respectively. Sulfanilamide was subjected to acid and alkali hydrolysis, oxidation, dry heat and wet heat treatment. According to the International Conference on Harmonization (ICH) guidelines the method was validated for precision, recovery and robustness. The ultraviolet (UV) spectra of the degradation products which had different spectra from sulfanilamide were also recorded.Mehmet Cevik from Republic of Turkey Health Ministry-Refik Saydam Central Hygiene InstituteThe authors especially thank Mehmet Cevik from Republic of Turkey Health Ministry-Refik Saydam Central Hygiene Institute and Dr. Feyyaz Durap from Department of Chemistry, University of Dicle for support
Macrobenthic assemblages of newly introduced Caulerpa taxifolia from the Eastern Mediterranean coast of Turkey
No full textCaulerpa taxifolia is one of the most important and best-studied alien species in the Mediterranean Sea. The present study reveals the macrobenthic assemblages associated with C. taxifolia from the region. We found 26 species from Polychaeta, 31 species from Crustacea, 22 species from Mollusca and 5 species from Echinodermata. In conclusion, C. taxifolia in İskenderun Bay can be considered an ecosystem engineer that modifies local habitats and also enhances biodiversity. © 2011 Springer Science+Business Media B.V.109Y284 National Council for Scientific ResearchAcknowledgments The authors acknowledged The Scientific and Technological Research Council of Turkey (TÜBİTAK) for financial support (Grant number is 109Y284). The authors are also glad to thank Prof. Susan Williams from University of California at Davis for her valuable comments and proofreading
THE RADIOLOGICAL, CLINICAL AND FUNCTIONAL PROPERTIES OF HAND OSTEOARTHRITIS AND THEIR RELATION WITH RADIOLOGICAL FINDINGS IN A TURKISH POPULATION: TLAR-OA STUDY
No full textCongress of the European-League-Against-Rheumatism (EULAR) -- JUN 13-16, 2018 -- Amsterdam, NETHERLANDS[Abstract Not Available]European League Against RheumatismABVIEM. T. Duruoz Grant/research support from: ABVIE, Consultant for: NOVARTIS, Speakers bureau: ABDI IBRAHIM, D. Erdem: None declared, T. Tuncer: None declared, L. Altan: None declared, F. Ayhan: None declared, A. Bal: None declared, L. Cerrahoglu: None declared, E. Capkin: None declared, R. Cevik: None declared, D. Dulgeroglu: None declared, S. Gursoy: None declared, S. Hizmetli: None declared, C. Kacar: None declared, E. Kaptanoglu: None declared, T. Kaya: None declared, H. Kocabas: None declared, K. Nas: None declared, S. Ozcakir: None declared, D. Sindel: None declared, O. Sahin: None declared, G. Tasci Bozbas: None declared, C. Tikiz: None declared, H. Ugurlu: None declare
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy
No full textNeurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear. We studied cell death in Tg4510 mice that reversibly express P301L mutant human tau and accumulate NFTs using in vivo multiphoton imaging of neurofibrillary pathology, propidium iodide (PI) incorporation into cells, caspase activation, and DNA labeling. We first observed that in live mice, a minority of neurons were labeled with the caspase probe or with PI fluorescence. These markers of cell stress were localized in the same cells and appeared specifically within NFT-bearing neurons. Contrary to expectations, the PI-stained neurons did not die during a day of observation; the presence of Hoechst-positive nuclei in them on the subsequent day indicated that the NFT-associated membrane disruption, as suggested by PI staining, and caspase activation do not lead to immediate death of neurons in this tauopathy model. This unique combination of in vivo multiphoton imaging with markers of cell death and pathological alteration is a powerful tool for investigating neuronal damage associated with neurofibrillary pathology
Forecast combination approach with meta-fuzzy functions for forecasting the number of immigrants within the maritime line security project in Turkey
No full textIn this study, forecasting the number of immigrants on the Turkey\"s maritime line for use in a national security project carried out by Turkish Government within the scope of fight against uncontrolled immigration is discussed for the first time. Handling with the immigration problem is one of the biggest concerns of Turkey as unsupervised immigration can adversely affect the demographic and economic structure of the country. Precautions are needed as the short-, medium- and long-term impacts of undetected immigrants on the country\"s ecosystem are unpredictable, but due to the uncertainties inherent in immigration, the cost of using government resources such as patrol vehicles to capture undocumented immigrants can be extremely high. In order to both minimize the expenditure problem and keep immigration under control by providing a proper scan, forecasting the number of immigrants on the maritime line route is seen as an important problem and studied by probabilistic and non-probabilistic models. Since the data for 2020 and 2021 could not be attained yet due to COVID-19, in order to obtain forecasts and compare actual observations for 2019, which is the primarily focus of the research in this study, the dataset of interest on the number of daily immigrants between years 2016 and 2019 is obtained from Turkish Coast Guard Command within Ministry of Interior of Republic of Turkey. To obtain the most accurate forecasts, seven distinguished forecasting methods, from simple to complex, are implemented. Then, the forecast combination approach with meta-fuzzy functions which combines all methods is proposed. Consequently, the forecasting results are acquired and evaluated by using R. The evaluation of the results is made by using widely considered measurement accuracy metric root mean square error. According to the final assessments, the proposed approach gives more accurate forecasting results for the expected number of immigrants on the Turkey\"s maritime line and these results become an input to the national security project
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