202 research outputs found
Intervista a Maria Giovanna Arcamone: un viaggio attraverso l\u27onomastica e la toponomástica
No full textIl contributo dalla Prof.ssa Arcamone agli studi di onomastica e toponomastica in più di mezzo secolo di incessante lavoro è davvero di natura incalcolabile. Basti pensare ai suoi contributi pioneristici sugli studi dei toponimi longobardi o al contributo determinante dato alla scena onomastica letteraria italiana con la fondazione di il Nome nel testo insieme al compianto prof. Davide De Camilli e alla prof. Donatella Bremer. Ma ciò ovviamente è una goccia infinitesimale di una voce importante che ha saputo ispirare generazioni di studiosi non solo attraverso la caratura dei propri contributi ma anche con un’incessante riflessione sul metodo di ricerca. Detto questo, la presente intervista ci consente di ripercorrere alcune delle tappe di questo straordinario viaggio filologico, onomastico, linguistico ma soprattutto umano dove lo studio dei nomi non è solo un inerte materia per eruditi ma un mezzo per comprendere meglio e nel profondo il complesso mondo in cui viviamo.Prof. Arcamone\u27s contributions to the studies of onomastics and toponymy in over half a century of incessant work are truly invaluable. One only needs to consider her pioneering work on Lombard toponyms or her decisive contribution to the Italian literary onomastic scene through the founding of il Nome nel testo with the late Professor Davide De Camilli and Professor Donatella Bremer. But this is obviously an infinitesimal drop of an important author that has been able to inspire generations of scholars not only through her essays and books but also with a never-ending reflection on research methodology. This interview allows us to revisit some of the stages of the key moments of Professor Arcamone\u27s extraordinary lifelong research. Through her work, she has demonstrated that the study of names is not simply an inert academic subject, but rather a way to better and deeply understand the complex world in which we live
Muckraking the School District: The Journalist’s Role in Reforming Schools
No full textThis thesis examines the role of the media—particularly journalists—in sparking school reform. The author paints a grim picture of struggling schools, attributing growing issues of school violence to poor administration, school secrecy, and corruption. She argues that increasing parental and community awareness is key to confronting the problems faced by the educational system and seeking solutions. Arcamone discusses her experience publishing critical articles about the Long Beach school system and the resulting community reaction. She gives particular attention to the negative reactions she received from the school and defensive parents, and describes her own changing journalistic strategies for gaining community support when confronting the school’s problems. The thesis includes powerful and disturbing examples of the abuses endured by typical and special needs children at the hands of their school systems. The author concludes by presenting investigative journalism as a powerful means for revealing difficult truths and provoking communities and school systems to educational reform
Expression and distribution of leptin and ghrelin in the digestive ap-paratus of DIO (diet-induced obesity) zebrafish
No full textExpression and distribution of leptin and ghrelin in the digestive ap-paratus of DIO (diet-induced obesity) zebrafish
Maruccio L, Russo F, Arcamone N, Mania M, Randazzo B, Ciriaco E
In this report we analyzed the expression and distribution of leptin and ghrelin in the digestive apparatus of DIO zebrafish. Leptin is anorexigenic peptide while ghrelin is orexigenic one. They act as antagonists. In this study in order to develop an obesity phenotype adult zebrafish were divided into two dietary groups. The con-trol group was fed with Artemia (5 mg cysts/fish/day) once per day. The overfeeding group was fed three times per day with Artemia (60 mg cysts/fish/day). For calorie restriction, the zebrafish was fed with Artemia (2.5 mg cysts/fish/day) for 2 weeks after being overfed for 8 weeks. At the end of this period, after 24h of fasting, the zebrafish digestive apparatus were sampled for immunohistochemistry, western blotting and qRT-PCR techniques. Leptin and ghrelin immunoreactivity were found in the enteric nervous system and neuroen-docrine cells in overfeeding and control zebrafish intestine. The number of immunopositive cells is greater in DIO zebrafish than in control ones. In both groups leptin immunoreactive nervous fibers were found around ducts and vessels of liver. The presence of proteins were confirmed by western blotting analysis. By qRT-PCR, leptin and ghrelin mRNA levels are higher in the overfeeding zebrafish intestine and in control zebrafish liver. The immunological detection of ghrelin and leptin in control zebrafish are in agreement with literature data. In DIO zebrafish the results are similar to those found for obese mammals. In conclusion, this study represent a starting point to investigate the mechanisms involved in the regulation of appetite and energy balance in DIO zebrafish
CHELATION OF COPPER(II) IONS BY DOXORUBICIN AND 4'-EPIDOXORUBICIN - AN ELECTRON-SPIN-RESONANCE STUDY
No full textIl padule di Suese (Livorno) sito di importanza comunitaria: materiali per un piano di gestione
No full textMuckraking the School District: The Journalist’s Role in Reforming Schools
No full textRepository staff redacted information not essential to the integrity of this thesis to protect privacy.This thesis examines the role of the media—particularly journalists—in sparking school reform. The author paints a grim picture of struggling schools, attributing growing issues of school violence to poor administration, school secrecy, and corruption. She argues that increasing parental and community awareness is key to confronting the problems faced by the educational system and seeking solutions. Arcamone discusses her experience publishing critical articles about the Long Beach school system and the resulting community reaction. She gives particular attention to the negative reactions she received from the school and defensive parents, and describes her own changing journalistic strategies for gaining community support when confronting the school’s problems. The thesis includes powerful and disturbing examples of the abuses endured by typical and special needs children at the hands of their school systems. The author concludes by presenting investigative journalism as a powerful means for revealing difficult truths and provoking communities and school systems to educational reform.SUNY BrockportEducation and Human DevelopmentMaster of Science in Education (MSEd)Education and Human Development Master's These
Non-Covalent Complexes between DNA-Binding Drugs and Double-stranded Deoxyoligonucleotides: A Study by Ionspray Mass Spectrometry
No full textBinding of Epstein-Barr virus nuclear antigen 1 to DNA: inhibition by distamycin and two novel distamycin analogues
No full textModulation of the interaction between cellular or viral transcription factors and target DNA sequences may represent a potential experimental strategy to control proliferation of neoplastic cells as well as virus DNA replication. Distamycin represents a likely candidate to mediate such modulation by pharmacological means. In order to obtain more detailed information on structure-activity relationships of these compounds, we have analysed the effects of distamycin and two distamycin analogues on the binding of a recombinant protein, the Epstein-Barr virus nuclear antigen 1 (EBNA-1) to its target sequence of Epstein-Barr virus, containing the 12 bp palindromic consensus TAGCATATGCTA. The sequence selectivity in the binding of distamycin to DNA was evaluated by footprinting experiments, while the effects of distamycins on DNA-protein interactions was analysed by means of electrophoretic mobility shift assay. The data presented in this paper suggest that distamycin and its analogues differentially inhibit the interaction between DNA-binding proteins and target DNA sequences
Thrombin generation in children with acute lymphoblastic leukemia: effect of leukemia immunophenotypic subgroups
No full textElevated plasma concentrations of endogenous thrombin generation markers and thrombotic events have been reported in children with leukemia. The aim of this study was to evaluate the effects of cancer and its treatment on thrombin generation (TAT levels) in children with acute lymphoblastic leukemia (ALL). The authors evaluated 32 children (23 M, 9 F) aged between 1 and 15 years (mean 6) affected by ALL (immunophenotypic subgroups: 16 common, 7 T, and 9 pre-B type). In all patients TAT levels at onset and after 5-6 doses of L-asparaginase were evaluated. TAT levels were higher in patients both at onset (13.04 ± 10.90 ng/L) and after the 5-6 doses of L-asp (19.41 ± 11.05 ng/L) with respect to controls (4 ± 1 ng/L) (p < .001 and p < .001). TAT levels after 5-6 doses of L-asp were higher than those at onset (p < .001). Factorial ANOVA showed that at onset there was a significant effect of leukemia immunophenotypic subgroups upon TAT levels (p < .05) and no effect of inherited thrombotic risk factors. These results indicate that in children with ALL an important role is played by acquired thrombotic risk factors, among which the indirect cancer procoagulant activity has its importance
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