60 research outputs found
Carcinoid heart disease : a rare cause of right ventricular dysfunction. Evaluation by trnsthoracic 2D, doppler and 3D echocardiography
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Pharmacological evidence for a dual GABAergic regulation of growth hormone release in humans
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Il diabete tossico da streptozotocina: un modello sperimentale per valutazioni di complicanze oftalmologiche
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Pharmacological evidence for a dual GABAergic regulation of growth hormone release in humans
No full textEffects of sodium valproate, which is believed to act via a gamma-aminobutyric acid mechanism, on basal and exercise-induced rise of growth hormone release have been tested in eighteen healthy volunteers. The exercise test consisted of using a stationary bicycle ergometer at 450 kg/min for 20 min. 600 mg per os of the drug resulted in a significant enhancement in plasma hormonal concentrations, whereas no effects were induced by placebo (p less than 0.005). Conversely, the growth hormone rise stimulated by exercise was markedly inhibited by sodium valproate (p less than 0.001 and p less than 0.01 at time 20, 40 and 60 min respectively). The results of this study are consistent with the hypothesis that a dual GABAergic control of growth hormone secretion is present in man
EVIDENCE FOR A GABAERGIC CONTROL OF THE EXERCISE-INDUCED RISE IN GH IN MAN
No full textThe effect of the GABAergic drug sodium valproate (SV) on the exercise-induced release of growth hormone (GH) was investigated in 10 healthy males. The exercise test consisted of using a stationary bicycle ergometer at 450 kg/min for 20 min. SV 600 mg blunted the increase in GH induced by the exercise, suggesting GABAergic regulation of GH secretion in man, at least under certain physiological conditions. © 1985 Springer-Verlag
Topographic Fingerprint of Deep Mantle Subduction
No full textThe dynamic topography links with the mantle structures at various temporal and spatial scales. However, it is still unclear how it relates to the dynamics of subducting lithosphere when plates reach the mantle transition zone and lower mantle. Seismic tomography images show how slab morphologies vary from sinking subvertically into the lower mantle, to lying flat above the upper-lower mantle discontinuity, to thickening in the shallow lower mantle. These slab shapes have been considered to be the result of variable interaction of the slab with the upper-lower mantle discontinuity at ~670 km depth. Previous studies show that periodic deep slab dynamics can explain a variety of enigmatic geological and geophysical observations such as periodic variations of the plate velocities, trench retreat and advance episodes, and the scattered distribution of slab dip angle in the upper mantle. In this study, we use two-dimensional subduction models to investigate the surface topography expression and its evolution during slab transition zone interaction. Our models show that topography does not depend on slab morphology; indeed, the dynamic topography cannot distinguish between a slab sinking straight into the lower mantle and slab stagnation at the upper-lower mantle boundary. However, topographic oscillations are related to episodes of the trench advance and retreat, which in turn are linked to the slab folding behavior at transition zone depths. Our results suggest that the surface transient signal observed by geological studies could help to detect deep subduction dynamics
Recipient-born bloodstream infection due to extensively drug-resistant Acinetobacter baumannii after emergency heart transplant: report of a case and review of the literature.
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