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Effect of long-term isradipine treatment on the hypertension-dependent changes in coronary arteries in spontaneously hypertensive rats.
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AUTORADIOGRAPHIC LOCALIZATION OF THE GABA-A-RECEPTOR AGONIST (3H)-MUSCIMOL IN THE RAT INTESTINAL MUSCULATURE
No full textRadioreceptor-binding assay and autoradiography were used to study the pharmacological profile and the anatomical localization of GABA-A-receptor sites in sections of rat duodenum, jejunum and ileum. (H-3)-Muscimol, used as a ligand, was bound by sections of the intestinal portions investigated in a manner consistent with the labeling of GABA-A-receptor sites. The dissociation constant (K(d)) was about 12.5 nmol/l in the three different intestinal portions. The maximum density of binding sites (B(max)) was highest in the duodenum (118.9 +/- 7.4 fmol/mg tissue followed, in descending order, by the jejunum (105.8 +/- 6.3 fmol/mg tissue) and the ileum (67.8 +/- 5.9 fmol/mg tissue). Light microscope autoradiography revealed a dense accumulation of specific silver grains within intestinal smooth muscle. In the duodenum (H-3)-muscimol-binding sites were rather homogeneously distributed both in circular and longitudinal smooth muscle. In the jejunum the density of silver grains was similar to that seen in the duodenum in the circular musculature and lower in the longitudinal musculature. The ileum displayed the lowest accumulation of (H-3)-muscimol-binding sites, with no significant differences in the density of silver grains between the two muscular layers. The possible significance of the GABA-A-receptor sites observed in the intestinal musculature is discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cholinergic neurotrasmission markers in the brain of rats treated with a cholinesterase inhibitor
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