1,721,158 research outputs found
Is it safe to withdraw etanercept in established rheumatoid arthritis after low disease activity achievement?
No full textSTUDIO DEL PROFILO CARDIO-VASCOLARE IN PAZIENTI CON ANGIOEDEMA DA CARENZA DI C1 INIBITORE: RELAZIONI TRA IL SISTEMA NERVOSO AUTONOMO E LA VASO-REATTIVITA¿
Full text linkBackround: Hereditary angioedema (HAE) is a rare autosomal disease resulting from a inherited deficiency or dysfunction of the C1 inhibitor. It is characterized by acute attacks of angioedema that involve skin, upper airway and gastrointestinal tract. Psychological stress is a well recognized trigger for angioedema attacks mediated by bradykinin, a peptide released from cleavage of high molecular weight kininogen (HK) by plasma callicrein.
Study aim: In this study we investigated the interaction of sympathetic nervous system and contact system to better understand the relationship between psychological stress and angioedema attacks.
Methods: 16 patients with hereditary angioedema during remission and 12 healthy volunteers were studied. ECG and beat-to-beat blood pressure were recorded during rest and 75° head-up tilt. Plasma catecholamines, C1 inhibitor, C4 and cleaved high molecular weight kininogen were assessed. Cardiovascular signals were analyzed by means of spectral analysis of heart rate variability, allowing to extract low and high-frequency components, indexes of respectively sympathetic and vagal modulation.
Results: During rest significant differences in systolic blood pressure and noradrenaline levels in HAE patients compared with healthy volunteers were observed. During tilt a significant reduction in low-frequency modulation increase was observed in HAE patients. No change was observed in C1 inhibitor and C4 between rest and tilt in both groups; tilt was associated with a significant increase in cleaved HK as compared to rest in HAE patients and healthy volunteers.
Discussion: In HAE patients higher systolic blood pressure and noradrenaline values suggest an increased sympathetic activation in rest. They showed a normal autonomic cardiovascular modulation in rest while a reduction in sympathetic activation was observed during tilt. The increase in the cleavage of HK upon sympathetic activation suggests a link between stress and bradykinin generation
Lifting of the maxillary sinus: complementary use of platelet rich plasma, autologous bone deproteinised bovine bone. Case report [Rialzo del seno mascellare: uso complementare di plasma arricchito di piastrine, osso autologo e osso bovino deproteinizzato. Caso clinico.]
No full textThe present paper describes a clinical case in which autologous bone, removed during an operation from the maxillary tuberosity, platelet rich plasma (PRP) and deproteinised bovine bone (Bio-oss, Geistlich) were used as graft material in a bilateral maxillary sinus lift procedure. During the same operating session, it was planned to carry out the lift of the maxillary sinus, employing a "combined" graft (autologous bone, PRP, deproteinised bovine bone), and to insert 6 fixtures at maxillary level, 3 in each quadrant, and 6 fixtures at mandibular level. The use of PRP, or rather of the platelet gel derived from it, represented an improvement compared to standard bone graft techniques. A graft consisting of autologous bone and PRP (with or without deproteinised bovine bone) makes it possible in fact to carry out more demanding operations, such as a major lift of the maxillary sinus, without the need for a block graft, but employing autologous bone particulate, which is easier to find. Furthermore, a "combined" graft is easily malleable and adjustable and can be adapted perfectly to the bone defect in which it is inserted. Finally, it guarantees a better quality of cure both in terms of speed and degree of mineralisation. This is very important if we consider that usually, lifting of the maxillary sinus is carried out precisely to guarantee adequate bone volume in cases where bone has been lost and to permit the insertion of osteointegrated implants
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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