1,122 research outputs found
Land and changing social relations in South Africa's former reserves : the case of Luphaphasi in Sakhisizwe Local Municipality, Eastern Cape.
No full textIncludes abstract.
Includes bibliographical references
Computation of the bluff-body sound generation by a self-consistent mean flow formulation
No full textThe sound generated by the flow around a circular cylinder is numerically investigated by using a finite-element method. In particular, we study the acoustic emissions generated by the flow past the bluff body at low Mach and Reynolds numbers. We perform a global stability analysis by using the compressible linearized Navier-Stokes equations. The resulting direct global mode provides detailed information related to the underlying hydrodynamic instability and data on the acoustic field generated. In order to recover the intensity of the produced sound, we apply the self-consistent model for non-linear saturation proposed by Mantič-Lugo, Arratia, and Gallaire ["Self-consistent mean flow description of the nonlinear saturation of the vortex shedding in the cylinder wake," Phys. Rev. Lett. 113, 084501 (2014)]. The application of this model allows us to compute the amplitude of the resulting linear mode and the effects of saturation on the mode structure and acoustic field. Our results show excellent agreement with those obtained by a full compressible simulation direct numerical simulation and those derived by the application of classical acoustic analogy formulations
Integrated simulation and optimization of continuous pharmaceutical manufacturing
No full textThe goal of this work focuses mainly in the development of reduced-order modeling tools for the design and optimization of manufacturing of pharmaceutical oral solid dosage form products. This work- as part of a collective effort of the Engineering Research Center for Structured Organic Particulate Systems (ERC-SOPS)- aims to combine all the research findings of the Center in terms of material properties and process understanding in order to design efficient continuous integrated manufacturing processes. Different surrogate-based methodologies are assessed for reduced-order model building based on either experimental data or computer simulation data. In addition, the effects of uncertainty of the available data, material properties and model parameters on model performance are addressed systematically. Finally, unit operation models are combined into a flowsheet simulation model which can be used for process design through the development of a simulation-based optimization strategy for noisy expensive flowsheets with complex constraints.Ph. D.Includes bibliographical referencesIncludes vitaby Fani Boukouval
Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy
No full textAmyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions are neurodegenerative disorders that share the cytosolic deposition of TDP-43 (TAR DNA-binding protein 43) in the CNS. TDP-43 is well known as being actively degraded by both the proteasome and macroautophagy. The well-documented decrease in the efficiency of these clearance systems in aging and neurodegeneration, as well as the genetic evidence that many of the familial forms of TDP-43 proteinopathies involve genes that are associated with them, suggest that a failure of these protein degradation systems is a major factor that contributes to the onset of TDP-43-associated disorders. Here, we inserted preformed human TDP-43 aggregates in the cytosol of murine NSC34 and N2a cells in diffuse form and observed their degradation under conditions in which exogenous TDP-43 is not expressed and endogenous nuclear TDP-43 is not recruited, thereby allowing a time zero to be established in TDP-43 degradation and to observe its disposal kinetically and analytically. TDP-43 degradation was observed in the absence and presence of selective inhibitors and small interfering RNAs against the proteasome and autophagy. We found that cytosolic diffuse aggregates of TDP-43 can be distinguished in 3 different classes on the basis of their vulnerability to degradation, which contributed to the definition-with previous reports-of a total of 6 distinct classes of misfolded TDP-43 species that range from soluble monomer to undegradable macroaggregates. We also found that the proteasome and macroautophagy-degradable pools of TDP-43 are fully distinguishable, rather than in equilibrium between them on the time scale required for degradation, and that a significant crosstalk exists between the 2 degradation processes.-Cascella, R., Fani, G., Capitini, C., Rusmini, P., Poletti, A., Cecchi, C., Chiti, F. Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy
Stability analysis and control of the flow in a symmetric channel with a sudden expansion
No full textThe laminar flow in two-dimensional diffusers may produce either symmetric or nonsymmetric steady solutions, depending on the value of the Reynolds number as compared with some critical value. The stability properties of the flow are studied in the context of linear theory. In this context, a sensitivity analysis of the flow instability is carried out with respect to perturbations that may be produced by a realistic passive control, thus providing qualitative hints and quantitative information for the control design. Following the so-obtained information, a passive control is built by introducing a small cylinder in the flow with the aim of stabilizing the unstable symmetric flow configuration in the diffuser. The effectiveness of this control is finally assessed by direct numerical simulation. It is shown that the introduction of the cylinder, placed following the indications of the linear sensitivity analysis in the stable asymmetric flow configuration, allows a steady completely symmetric or less asymmetric flow to be recovered. The flow transient between the uncontrolled asymmetric solution and the symmetric controlled one is analyzed in terms of streamlines and vorticity evolution; the effects of the cylinder introduction on flow dissipation are also assessed
Exploring and Preserving the Islamic Manuscript Heritage of Sub-Saharan Africa
No full textThe chapter offers an overview of the Arabo-Islamic manuscript heritage of Sub-Saharan Africa, with a particular focus on the region of the Horn of Africa. Its sections deal with the different typologies of Sub-Saharan Islamic books, the main codicological features of Sub-Saharan manuscripts, the typologies of book collections and their related conservative problems, the preservation strategies to be applied
The Lexicographical and Grammatical Studies by Giovanni Battista Raimondi (Rome ca. 1580 – 1614)
No full textThe scientific activity of the orientalist Giovanni Battista Raimondi is inextricably connected to the editorial projects of the Roman Typographia
Medicea , which he directed from 1584 until his death. The present contribution focuses on unpublished grammars, lexica and other didactic materials of Syriac, Arabic, Persian and Turkish that were either produced or projected by Raimondi between the end of the 16th and the first decade of the 17th cent. A great number of grammatical and lexicographical notes, together with drafts and printing proofs are preserved in Florentine libraries as well as at the Vatican Library, witness of Raimondi’s approach in learning as well as teaching and describing Oriental languages. Such documents,
with very few exceptions, have not been studied so far; we examine here this material from two different perspectives: the method for learning and self-teaching languages, on the one hand, and the organization and presentation of information in the didactic tools that he published (or prepared for publication) on the other
Fibrocapsa japonica (Raphidophyceae) occurrence and ecological features within the phytoplankton assemblage of a cyclonic eddy, offshore the Eastern Alboran Sea.
No full textThe Raphidophycean Fibrocapsa japonica Toriumi & Takano was detected for the first time offshore in the Eastern Alboran Sea (Western Mediterranean) in October 2006. Its distribution appeared very localised and atypical, as it was abundant in the open waters of a cyclonic eddy. Microscope counts of the natural phytoplankton assemblages revealed that F. japonica was dominant in the microplankton, together with Dinophyceae, within and below the cyclonic nutrient-rich dome (25 - 30 m). Bacillariophyceae were the primary microplanktonic fraction in only a few samples on the edges of the eddy. Moderately high abundances of F. japonica (maximum of 60 cells ml-1), with preliminary cysts and many cells aggregated in mucous nets, indicated a senescent phase. Despite the Atlantic origin of the cyclonic water masses, the molecular identification and the water temperature of 15 °C, which could have favoured pre-cyst formation, would suggest a Mediterranean source for F. japonica cells. Finally, we hypothesise that F. japonica, which is generally a coastal species, could have a coastal origin. In fact, F. japonica was mainly detected at a depth of 40-60 m at the coastal sites and at 25-30 m at the cyclonic dome. F. japonica generally being a coastal species, it can be hypothesised that it was entrapped by the cyclonic eddy, which typically detaches from the coastal waters, and thus carried offshore to the cyclonic waters
Zeina Fani Alpi, Dévotions lapidaires : reliefs divins du Liban romain
No full textSous le joli titre de « Dévotions lapidaires », Zeina Fani Alpi propose un recueil exhaustif des reliefs du Liban romain se référant aux dieux, un travail très soigneux, qui examine à la fois les questions de forme et de contenu, avec finesse et sagacité, un ouvrage précieux et attendu qui rendra de grands services aux historiens de l’art, aux archéologues et aux historiens des religions. Rolf Stucky, dans sa courte Préface (p. 5) souligne d’emblée le caractère « narratif » de ces documents f..
Printing the Qur’an in Rome: From the Typographia Medicea to Marracci’s Paduan Edition
No full textIl saggio si basa sullo studio di fonti inedite relative alla Typographia Medicea, fondata a Roma nel 1584, sotto la supervisione scientifica dell'orientalista Giovanni Battista Raimondi. In particolare si fa riferimento al progetto di edizione traduzione e confutazione del Corano. Tale progetto, e in particolare la possibilità di stampare a Roma il Corano, vengono messi in relazione con la più tarda vicenda editoriale relativa all'edizione del Corano di Ludovico Marracci
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