3,192 research outputs found

    Spontaneous music : the first generation British free improvisers

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    The British free improvisation scene originated in London and Sheffield during the mid 1960s. In groups such as AMM, the Spontaneous Music Ensemble and Joseph Holbrooke, a distinctive and ambitious musicality developed that still occupies most of its protagonists forty years later. Marked stylistic contrasts developed within the genre, notably the `atomistic' and `laminar' methods of interaction. Nonetheless, a consistency of principle and practice was also apparent that defined British free improvisation as unique. In some respects the genre resembled its German, Dutch and American counterparts, and also the jazz and classical avant-gardes that had inspired them. Both conceptually and practically, however, clear differences remained. The British free improvisers refined a method and an aesthetic of musical creativity, which suggested an intimate perspective and a detailed analysis of that which we accept as `music'. Its techniques and results were unconventional, but remained consistent with music's defining concepts and experiences. As such, British free improvisation suggested a more inclusive model of musicality than is common, and implied a broad critique of the cultural values that define `music' at all. Though the free improvisers themselves did not explicitly state the connection, their work may be viewed in the context of Deconstruction: the post-structuralist analytical strategy associated with philosopher Jacques Derrida. British free improvisation culminated from innovations within the twentieth century avant-garde. Referencing styles such as atonality and free jazz, it challenged the aesthetic, technical and hierarchical standards of Western tradition in a form that was striking and extreme, but also of logical development and focus. Free improvisation owed explicit debt to a variety of other musics; its most singular achievement however, was the redefinition of `rhythm' by which it disguised this fact. The music of the first generation British free improvisers is reliant upon precise conceptual and practical execution. But though this has enabled the genre to be musically innovative, in the long term it has also become a logical problem. With British free improvisation as its subject, the scrutiny of Deconstruction reveals significant discrepancies between what `free improvisation' implies and what it actually represents

    Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers

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    In the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)

    Enhancement of the HWRIC Database : Year 2 : With an Evaluation of Database Content

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    Made available in DSpace on 2007-09-08T22:21:48Z (GMT). No. of bitstreams: 1 RR-E24.PDF: 3812360 bytes, checksum: 9e4fef904935a08acfbc24a726a41fd6 (MD5) Previous issue date: 1988NTIS PB89-19709

    Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR

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    As cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health. MCs are known to have developmental toxicity, however, the possible molecular mechanism is largely unknown. This is the first toxicological study to integrate post-transcriptomic, proteomic and bioinformatics analysis to explore molecular mechanisms for developmental toxicity of MCs in zebrafish. After being microinjected directly into embryos, MC-RR dose-dependently decreased survival rates and increased malformation rates of embryos, causing various embryo abnormalities including loss of vascular integrity and hemorrhage. Expressions of 31 microRNAs (miRNAs) and 78 proteins were significantly affected at 72 hours post-fertilisation (hpf). Expressions of miR-430 and miR-125 families were also significantly changed. The altered expressions of miR-31 and miR-126 were likely responsible for the loss of vascular integrity. MC-RR significantly reduced the expressions of a number of proteins involved in energy metabolism, cell division, protein synthesis, cytoskeleton maintenance, response to stress and DNA replication. Bioinformatics analysis shows that several aberrantly expressed miRNAs and proteins (involved in various molecular pathways) were predicted to be potential MC-responsive miRNA-target pairs, and that their aberrant expressions should be the possible molecular mechanisms for the various developmental defects caused by MC-RR

    The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR

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    Microcystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress.Microcystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress

    So Tom has turned a poet, what a dear [first line]

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    strophicnasame as Box 192 Item 50Cover is duplicated in 192.050. Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box 192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.

    So Tom has turned a poet, what a dear [first line]

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    strophicnasame as Box 192 Item 50Cover is duplicated in 192.050. Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box 192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.

    So Tom has turned a poet, what a dear [first line]

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    strophicnaCover is duplicated in 192.051. Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box 192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.

    So Tom has turned a poet, what a dear [first line]

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    strophicnaCover is duplicated in 192.051. Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box 192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.

    FPGA-accelerated calculation of the correlation integral of RR intervals

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    Analiza sygnałów biomedycznych jest jednym z ważniejszych obszarów badań naukowych. Istnieje duże zapotrzebowanie na wydajne systemy obliczeniowe, które pozwalały by na analizę sygnałów biomedycznych wielu pacjentów. W artykule przedstawiono propozycję architektury systemu obliczającego całkę korelacji interwałów międzyuderzeniowych RR, wykorzystującego układ FPGA do akceleracji obliczeń.Biomedical signal analysis is a very important field of research. This paper describes architecture of FPGA-accelerated computational system proposed by Author. The main purpose of this system is calculation of the correlation integral of RR intervals in cardiological patients
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