483 research outputs found
Titanium Dioxide and Zinc Oxide Nanoparticles Are Not Mutagenic in the Mouse Lymphoma Assay But Modulate the Mutagenic Effect of Uv-C-Light Post Treatment
No full textWOS: 000395724300055There are no studies in the literature on nanomaterials (NMs) using gene mutation approaches in mammalian cells, which represents an important gap for genotoxic risk estimations. To fill this gap, mouse lymphoma L5178Y Tk(+/-) assay (MLA) was used to evaluate the mutagenic effect of titanium dioxide and zinc oxide nanoparticles (NPs). Two different NP sizes (between 1-50 and 50-100 nm) of each NP were used. The results indicate that both the selected NMs and their microparticulated forms do not have mutagenic effects. Nevertheless, pre-exposure to these NMs reduce the mutagenic effect of posterior UVC-light exposure, in an indirect concentration-effect relationship. As such, cells previously exposed to low concentrations of the selected NPs show better protective effects against posterior exposure to UVC-light. These in vitro results, obtained from mouse lymphoma cells, support the reproduction of the current literature date on these NPs' genotoxic potential as well as to focus on the discussion on the benefits/risks associated with their use in photo protection sunscreens.Scientific and Technological Research Council of Turkey (TUBITAK), Science Fellowships and Grant Programmes Department (BIDEB), International Post Doctoral Research Fellowship Programme, Ankara (Turkey) [2219]; Generalitat de Catalunya (CIRIT)Generalitat de Catalunya [2014SGR-202]Esref Demir was supported by a postdoctoral fellowship from the Scientific and Technological Research Council of Turkey (TUBITAK), Science Fellowships and Grant Programmes Department (BIDEB), 2219-International Post Doctoral Research Fellowship Programme, Ankara (Turkey). This investigation has been supported in part by the Generalitat de Catalunya (CIRIT, 2014SGR-202). We wish to thank Gloria Umbert for her excellent technical assistance
Toxic and genotoxic effects of graphene and multi-walled carbon nanotubes
No full textDemir, Esref/0000-0002-2146-7385WOS: 000435122700004PubMed: 29873610Graphene and multi-walled carbon nanotubes (MWCNT) are widely used in nanomedicine, and other fields, due to their unique physicochemical properties including high tensile strength, ultra-light weight, thermal and chemical stability, and reliable semi-conductive electronic properties. Although extensive amount of data exist describing their adverse effects including potential genotoxicity, few studies using gene mutation detection approaches in mammalian cells are available, which represents an important gap for risk estimations. The aim of the present study was to determine the effects of graphene or MWCNT [as pure, carboxyl (COOH) functionalized, and amide (NH2) functionalized] on cytotoxicity, intracellular levels of reactive oxygen species, apoptosis, gene expression changes, and gene mutation induction in L5178Y/Tk(+/-)3.7.2C mouse lymphoma cell line. Although some adverse effects were observed at concentrations of 350 and 450 mu g/ml, which are excessive and not environmentally relevant levels, no marked effects were detected at concentrations of 250 mu g/ml and lower. This is the first study reporting cytotoxicity, mutagenicity, and gene expression findings in the mouse lymphoma cell line for graphene and different MWCNT forms at high concentrations; however, the biological relevance of these observations needs to be assessed following chronic in vivo exposure
Drosophila as a robust model system for assessing autophagy: a review
No full textAutophagy is the process through which a body breaks down and recycles its own cellular components, primarily inside lysosomes. It is a cellular response to starvation and stress, which plays decisive roles in various biological processes such as senescence, apoptosis, carcinoma, and immune response. Autophagy, which was first discovered as a survival mechanism during starvation in yeast, is now known to serve a wide range of functions in more advanced organisms. It plays a vital role in how cells respond to stress, starvation, and infection. While research on yeast has led to the identification of many key components of the autophagy process, more research into autophagy in more complex systems is still warranted. This review article focuses on the use of the fruit fly Drosophila melanogaster as a robust testing model in further research on autophagy. Drosophila provides an ideal environment for exploring autophagy in a living organism during its development. Additionally, Drosophila is a well-suited compact tool for genetic analysis in that it serves as an intermediate between yeast and mammals because evolution conserved the molecular machinery required for autophagy in this species. Experimental tractability of host–pathogen interactions in Drosophila also affords great convenience in modeling human diseases on analogous structures and tissues.No sponso
Environmental Toxicology and Human Health
No full textHumans and animals may be exposed on a continuous daily basis to a mixture of environmental contaminants that may cause adverse consequences. This Topic focuses on environmental pollutants including heavy metals, pesticides, nanoparticles, micro-nanoplastics, indoor air pollutants, pharmaceuticals, and industrial toxicants with effects on human health, risk assessment, and the relationship between various diseases and environmental pollutants. The aim of this Topic is to present a comprehensive overview of various studies carried out with in vivo and in vitro model organisms and the potential risks posed by environmental pollutants to human health. In this Topic, 20 original articles, 6 reviews and 1 communication are collected, with a particular focus on alcohol-based hand sanitizers, polycyclic aromatic hydrocarbons, monochromatic light pollution, paraben as an endocrine disruptor, heavy metal pollution attributed to the antimony and arsenic found in mines in soil, water, and sediments, groundwater with high fluoride levels, the transmission of viruses due to the heating, ventilation, and air conditioning systems of urban subways, chronic home radon exposure, organotin compounds, heavy metal pollutants, polypropylene microplastics, ventral body wall defects in chick embryos, microcystin-LR as an aquatic toxin, N-nitroso compounds, methylmercury as a global pollutant, triazine herbicides, persistent organic pollutants, bisphenol A and trace metals, autophagy, nano- and micro-sized polystyrene particles, tributyltin as an environmental contaminant, polybrominated diphenyl ethers, and per- and polyfluoroalkyl substances
Demir Baba : saint et héros des musulmans hétérodoxes en Bulgarie
No full textL’auteur présente les kızılbaş en soulignant leur non-conformisme politique et leur messianisme. Situé dans ce contexte à partir de son vilayetname, Demir Baba fait alors l’objet d’une analyse historique et culturelle.The author sets out the kızılbaş by emphasizing their non-conformism and messanism. In this context, thanks to his vilayetname, Demir Baba is analyzed in an historical and cultural perspective
Demir Baba : saint et héros des musulmans hétérodoxes en Bulgarie
No full textL’auteur présente les kızılbaş en soulignant leur non-conformisme politique et leur messianisme. Situé dans ce contexte à partir de son vilayetname, Demir Baba fait alors l’objet d’une analyse historique et culturelle.The author sets out the kızılbaş by emphasizing their non-conformism and messanism. In this context, thanks to his vilayetname, Demir Baba is analyzed in an historical and cultural perspective
Approach for siting a support facility for transporting supplies in emergency cases in the Republic of Bulgaria
No full textIn this paper, the author determines the most suitable transportation location for intervention in a large scale disaster in the Republic of Bulgaria, by means of the Weber Problem and the Weiszfeld method. The objective is to minimise the cost of transporting emergency supplies across the country by locating a support facility, and thus reaching the area of event at the lowest possible cost. A brief description of the Weiszfeld method is provided in the paper. Further, using recent population data of both provinces and municipalities, the method is applied respectively to obtain the results. They were compared in terms of spatial correspondence and the final facility location was fixed. Erecting the supply site is recommended to help decrease the losses
Islamophobia from the inside: how Turkish immigrants responded to the securitization of integration in Germany and the Netherlands
No full textAlthough there is a vast literature on the securitization and Islamophobia phenomena in Western societies, there is relatively less research about the perceptions and mobilization of Muslim immigrants in the West, especially Turks, with respect to these phenomena. Therefore, the research set out to explore whether there has been any change in the forms of mobilization of Turkish immigrants in Germany and the Netherlands after 9/11 as a response to the securitization of integration. The present comparative study identified not only the changes after 9/11, but also the main similarities and differences between the two cases. Characteristics of Turkish immigrants and the context of reception, as well as the subjective aspects (such as perceptions, feelings, emotions, and so on) related to the issue were taken into account in the study. From the methodological perspective, the study employed a mixed methods research approach by including interviews, participant observation, and a quantitative analysis of population and political representation data. In total, in Germany and the Netherlands, 27 face to face semi-structured interviews were conducted with either the representatives of Turkish organizations or the political party members that originated from Turkey. The study concluded that Turkish immigrants in both countries have been negatively affected by the securitization process. They felt that they faced more problems (such as discrimination, hate crimes, more restrictive policies towards them, and so on) in their contexts after 9/11. Along with these perceptions, the changes in their characteristics and the context of reception played an important role in their mobilization in this process. The study revealed that they became more mobilized and organized after 9/11. After evaluating the motives and objectives of mobilization and acculturation strategies of Turkish immigrants, the study identified three main forms of mobilization (political, social, and cultural) as a response to the securitization of integration. Not only differences between the characteristics of Turkish immigrants in Germany and the Netherlands but also dissimilarities in their receiving contexts resulted in differences in their political mobilization approaches. However, their social and cultural mobilization approaches in both countries have mainly been similar.Ph.D.Includes bibliographical referencesIncludes vitaby Esref Ertur
Bibliometric analysis of the results of Reiki research
No full textIntroduction: This study analyses bibliometric indicators to assess global research trends on Reiki, including publication patterns and key contributing countries. Methods: The publications included in Web of Science (WOS) databases between 1970 and 2024 were reviewed. The WOS database was searched using TS= “REIKI” and all WOS indexes were included. This search identified 414 studies. Among them, letters (n = 7), editorial materials (n = 19), book reviews (n = 9), corrections (n = 2), art and poetry (n = 1), news (n = 1), and retracted publications (n = 1) were removed. The remaining 374 articles were included in this bibliometric analysis. The R-package for bibliometric analysis (Bibliometrix) was used. Results: The bibliometric analysis found that researchers published Reiki-related studies between 1983 and 2024, with a publication growth rate of 4.47 %. On average, articles were 9.5 years old and received 13 citations per document. The total number of keywords identified by the authors was 553, the number of authors in the articles was 1124 authors, the number of single-author articles was 70, the average number of publications per author was 3.5, and international co-authorships were 7.219 %. The USA, Brazil, the United Kingdom, Canada, and Turkiye were the top five countries that published on Reiki, respectively. The USA, Canada, the United Kingdom, Australia, and Turkiye were the top five countries with the most cited articles, respectively. Vitale A. is the most cited author. Journal of Alternative and Complementary Medicine is the most cited journal. Conclusion: This study is the first of its kind to evaluate the articles written by researchers in the field of Reiki only. Despite the difficulties researchers experienced in the field of Reiki, the studies have increasingly been conducted in this field over the years and have been cited studies more. This study may be helpful for researchers to determine productive countries, journals, authors, and emerging trends in Reiki by providing comprehensive analyses and structured information on this subject. © 202
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