48 research outputs found
The Psychometric Properties of the Figure-Of Walk Test in People With Parkinson's Disease
No full textGulsen, Cagri/0000-0001-5830-438X; Erkoc Ataoglu, Esra/0000-0001-5465-6089Purpose To investigate: (1) the interrater, and test-retest reliability of the figure-of-eight walk test (F8WT) in people with Parkinson's disease (PwPD); (2) the minimum detectable change in the F8WT times; (3) the concurrent and known-groups validity of the F8WT times; and (4) the cut-off times that best discriminate PwPD from healthy people and fallers from non-fallers with PD. Methods This was a cross-sectional study. Forty-three PwPD and 34 healthy people were recruited. The F8WT was performed along with the timed up and go test, 10 m walk test, Berg Balance Scale, Activities-Specific Balance Confidence Scale, Unified Parkinson's disease Rating Scale, and Hoehn and Yahr Scale. Results The F8WT showed good interrater and test-retest reliability (ICC = 0.964-0.978 and ICC = 0.905-0.920, respectively). The MDC was 2.77 s. The F8WT was correlated with other outcome measures. Significant differences in the F8WT times were found between PwPD and healthy people and between fallers and non-fallers with PD (p < 0.001 and p < 0.001, respectively). The cut-off times of 8.43 s best discriminated PwPD from healthy people, while 11.19 s best discriminated fallers from non-fallers with PD. Conclusions The F8WT is a reliable, valid, and easy-to-administer tool in assessing the walking skill of PwPD.Science Citation Index Expanded - Social Science Citation Inde
Association between proinsulin and cardiovascular events
No full textAim: Coronary artery disease (CAD) still remains an important cause of death in spite of all advances in treatment. There are many risk factors for CAD. The aim of the present study was to evaluate the effect of of-of proinsulin on cardiovascular morbidity and mortality in nondiabetic coronary artery disease.
Material & Method: Nondiabetic 38 (8 female, 30 male) patients diagnosed with the acute coronary syndrome (ACS) admitted to coronary ICU of Haseki Training and Investigation Hospital and 21 control cases (9 female, 12 male) without diabetes and any cardiovascular disease were included in the present study. Proinsulin and other biochemical parameters of the patients were recorded. Five years later, among patients with the acute coronary syndrome (ACS), those who have recurring ACS and those who do not have were compared in terms of proinsulin and other biochemical parameters.
Results: There was no significant difference between acute coronary syndrome patients and controls with regard to proinsülin, Proinsulin /İnsulin ratio, and HOMA-IR values. However, a significant difference was found in age and glucose/insulin ratio. Respectively p=0.017, p=<0.001. After five years of follow up, significant difference was found between ACS patients who experienced cardiac event again and those who did not do so in terms of systolic blood pressure and proinsulin levels. Respectively p=0.013, p=0.031. No statistically significant difference was found in other parameters.
Conclusion: No significant difference was found between patients with ACS and control groups with respect to proinsulin levels. p=0.072. However, after five years of follow up, proinsulin levels were found to be high (p=0.031 )in the group who reexperienced cardiac events, suggesting that proinsulin may be a marker or risk factor of cardiovascular risk in the long term
An evaluation of lateralizing signs in patients with temporal lobe epilepsy
No full textResective epilepsy surgery has been accepted as an effective treatment for patients with medically intractable temporal lobe epilepsy (TLE) to control the seizures and to limit cognitive dysfunction. Complete resection of the epileptic zone, and therefore the success of the surgery, depends on the identification of the seizure focus. Reliable lateralizing semiologic signs, together with other presurgical assessments, are of great importance for an accurate identification of the seizure focus. In this respect, this study evaluated the frequency of semiologic signs in medically intractable temporal lobe epilepsy (TLE) together with the lateralizing values and variations according to the age and gender groups. Two hundred seventy-three seizures of 55 patients of the Adult Epilepsy Monitoring Unit of Gazi University Faculty of Medicine with the diagnosis of medically intractable TLE, whose epileptic foci were detected through noninvasive presurgical procedures and seizures were controlled successfully after anterior temporal lobectomy (ATL), were analyzed retrospectively. Seizure semiologies of the patients were evaluated in terms of lateralizing values, and it was inquired whether age/gender causes any variation. Versive head rotation, unilateral dystonic limb posturing, asymmetric tonic limb posturing, and the combination of unilateral hand automatisms and dystonic posturing were determined as the semiologic signs with the highest lateralizing values (90-100%). While hand automatisms were observed frequently in the group with early seizure-onset age (onset age 2; p < .005). In addition to this, semiologic signs were noted to be different between male and female groups; psychic and autonomic auras and ictal emotional signs were associated with women (p < .005). (C) 2015 Elsevier Inc. All rights reserved
Hafif-Orta Evre Alzheimer Hastalığında MPV’nin Serebral Vasküler İskemik Yükle İlişkisi
No full textObjective: Vascular pathologies and chronic neuroinflammation play an important role in Alzheimer's Disease (AD). Increased platelet activity, which underlies the pathophysiology of atherosclerosis and systemic inflammation, has been reported several times of AD. However, the relationship between this increase and neuroimaging correlates has not been studied yet. This study aims to evaluate the relationship between mean platelet volume (MPV), as a reliable indicator of platelet activity, and vascular ischemic burden in neuroimaging of AD. Materials and Methods: Medical records of mild-moderate AD cases diagnosed in our dementia outpatient clinic between 2021-2022 were retrospectively reviewed. Patients were classified as having "mild" or "severe" vascular ischemic burden on MRI. Clinical findings and platelet markers (Platelet-PLT, Platelet Distribution Width-PDW, Mean Platelet Volume-MPV) were compared between the groups. Multivariate regression was applied for potential confounders regarding vascular ischemic burden. Results: Out of 59 patients, 36 had ‘mild' and 23 had 'severe' ischemic burden. Demographic and clinical features were similar; however, MPV was significantly higher in the group with severe ischemia (p:0.013). Multivariate analysis revealed an independent association between MPV and ischemic burden. An MPV value of ≥8.7 fL had a sensitivity of 69.6% and a specificity of 61% for severe burden. Conclusion: Our results highlight the role of platelet activation in the vascular pathogenesis of AD. During the early evaluation of AD, increased MPV can serve as a marker to determine the high-risk group in terms of cerebral ischemic burden. This might enable close monitoring and timely management of high-risk patients regarding the development of vascular morbidities
Frequency of Paroxysmal Nocturnal Hemoglobinuria Clone in Turkish Myelodysplastic Syndrome Group
No full textAim: Retrospective, cross-sectional, observational study to examine the frequency and features of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with myelodysplastic syndrome (MDS). Methods: Data were analyzed from the medical files of 41 MDS patients diagnosed and followed up in the hematology department at a referral center between 2006 and 2017. Descriptive data, cytogenetic and hematologic characteristics, prognostic features and PNH clone sizes were assessed. PNH clone sizes were evaluated using the fluorescently labeled inactive toxin aerolysin method. Results: The study population comprised 22 (53.7%) female and 19 (46.3%) male patients with confirmed MDS; the mean age of the patients was 68.20 +/- 9.84 years (range, 45-85). PNH clones were detected in eight (19.5%) patients. The number of patients with a PNH clone size of > 10%, > 1%, > 0.1% and > 0.01% was one, one, one and eigth, respectively (p< 0.001 for all subgroups). Conclusion: These data indicate that PNH clones exist in approximately one-fifth of MDS patients. Further studies on a more extensive cohort are required to better understand the pathophysiological and clinical relationships between MDS and PNH
Voluntary movement reverses the effect of cathodal transcranial direct current stimulation (tDCS) on corticomotor excitability
No full textSodium Glucose Cotransporter-2 (SGLT-2) Inhibitor Related Diabetic Ketoacidosis
No full textDiabetic ketoacidosis is a rare but serious and life-threatening acute complication of diabetes mellitus. It is characterized by ketoacidosis with other findings and should be treated immediately. In this case, a 33-year-old diabetic patient who admitted to the emergency department with diabetic ketoacidosis is presented. The patient was prescribed empagliflozin (sodium glucose cotransporter inhibitor-2) a month ago. The SGLT-2 inhibitors have been approved for use in the treatment of type 2 DM and are still not used in the treatment of type 1 DM. There are such reports of unusual side effects related SGLT-2 inhibitors, in the literature and among them, ketoacidosis is a rare and important side effect
The Investigation of Effects of Pregabalin and Duloxetine Treatment According to Personality Characteristics with Fibromyalgia Patients
No full textPulmonary functions in patients with subclinical hypothyroidism
No full textObjective: To determine whether alterations in pulmonary function takes place in subclinical hypothyroidism by examining the diffusion lung capacity and muscle strength of such patients
