74 research outputs found
The expedition of Humphry Clinker. [electronic resource] : By the author of Roderic [sic] Random. In two volumes. ... Cooke's edition. Embellished with superb engravings.
No full textAuthor of Roderic Random = Tobias George Smollett.- Plates are dated 1794.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
An Investigation of the Crystal Structure of dichloro-μ-tetra(n-butyrato)dirhenium(III)
No full textTitle: An Investigation of the Crystal Structure of dichloro-μ-tetra(n-butyrato)dirhenium(III), Author: Roderic J. Restivo, Location: ThodeDichloro-μ-tetra(n-butyrato)dirhenium(III) was examined by x-rays and found to consist of a centrosymmetric dimeric unit in an eclipsed rotomeric configuration with a short rhenium-rhenium bond length of 2.20(2)Å. A long rhenium-chlorine bond 2.53(1)Å is present in the molecular unit. The bonding in Re2(O2C.C3H7-N)4CL2 is discussed with reference to similar carboxylate dimer structures. A preliminary report on the structure of Re2(O4C.C3H7-N)2 is also presented.ThesisMaster of Science (MS
A Study of Physiological and Morphological Changes in Sporulating Cells of Saccharymyces cerevisiae
No full textTitle: A Study of Physiological and Morphological Changes in Sporulating Cells of Saccharymyces cerevisiae, Author: Roderic D. Pontefract, Location: ThodeAn aeration technique is described which gave high and consistent yield of yeast spores. Nuclear structures and divisions were studied in both vegetative and sporulating cells. The variation in glycogen and fat content of such cells was followed. These features of internal morphology are described and illustrated by five plates of figures. A comparison was made if the respiration of vegetative and sporulating cells in the presence and absence of substrate. Attempts were made to detect dipicolinic acid (pyridine-2,6-dicarboxylic acid) in yeast spores but no positive results were obtained. The comparative physiological significance of this is discussed. Correlations are made of certain physiological and cytological changes observed during the sporulation process.ThesisDoctor of Philosophy (PhD
A.B.D.'li tarihçi Roderic H. Davison'un hayatı ve eserleri
No full textÖZET Bu tez çalışmamızda, bir Osmanlı ve Türkiye tarihçisi olan Amerikalı Prof. Dr. Roderie H. Davison'un hayatı, tamamı İngilizce olan eserlerinin mahiyeti, düşünceleri ve Türk Tarihçiliğine katkıları incelenmeye çalışılmıştır. Çalışmamız 6 ana bölümden oluşmaktadır ve her bölüm belirli bir konu üzerinde toplanmıştır. Birinci bölümde Prof. Davison'un hayatı, bulunduğu görevler, aldığı burslar, meslekî kuruluşlardaki etkinlikleri, tebliğleri, öteki kuruluşlarda verdiği dersler, kitap yayıncılarına yaptığı danışmanlıklar ve George Washington Üniversitesi' ndeki akademik görevleri ile ilgili bilgiler sunulmuştur. İkinci bölümde Prof. Davison'un eserleri: Kitapları, ortak yayınlanan kitapları, kitapçıkları, yayınlan (makaleleri) eleştirileri ve incelemelerinin adlan, basıldığı yer ve yıl listesi verilmiştir. Üçüncü bölümde Prof. Davison'un tamamı İngilizce olan üç büyük eseri okunarak her kitabın kendi başlığı altındaki makaleler ayn ayn sıralanarak tercüme edilmiş ve her kitabın önsözü de dahil olmak üzere bütün makalelerin özeti yayım sırasına göre kitabın kendi başlığı altında takdim edilmeye çalışılmıştır. Dördüncü bölümde Prof. Davison'un Türkiye Tarihçiliğine Katkısı, özellikle yerli tarihçilerle de mukayese edilerek; onun gözüyle "Küçük Kaynarca Antlaşması Neden Önemlidir?" sorusuna cevap verilmeye çalışılmıştır. Bu çalışma esnasında Prof. Davison'un eserleri ve dipnotlarda adı geçen tarihçilerin eserleri temel kaynak olmuştur. Beşinci bölümde Prof. Davison'un Türkçeye çevrilen değişik makaleleri yayın sırasına göre hazırlanmış ve orijinal biçimleri muhafaza edilerek verilmiştir. Aynca, "The 'Dosografa' Church in the Treaty of Küçük Kaynarca" (Küçük Kaynarca Antlaşmasında "Dosografa" Kilisesi) adlı makale, Küçük Kaynarca Antlaşması Neden Önemlidir? sorusuna katkıda bulunacağı düşüncesiyle tarafımızdan tercüme edilmiş ve Türkçe Makaleler bölümünde yer almıştır. Altıncı bölümde Prof. Davison'un yakın meslektaşlan, öğrencileri ve sevenleri DavisonTa ilgili anılannı, sağlığında yaptıklan söyleşileri ve ölümünden sonraki değerlendirmeleri orijinal belgelerle desteklenmiş ve bu belgeler tez ekinde sunulmuştur. IABSTRACT This thesis deals with Prof. Dr. Roderic H. Davison, an American historian specialized in the Ottoman and the Turkish history; his biography, the purpose of his books which all written in English, his ideas and contributions to the Ottoman and the Turkish history. The thesis consists of 6 main chapters, each of which concentrates on a particular point of subject. Chapter One consists of Prof. Davison's autobiography, positions held, fellowships, activities in professional associations, papers presented at professional meetings and conferences, lectures given at other institutions, consultant to publishers, on book manuscripts and services at the George Washington University. Chapter Two consists of Prof. Davison's works: Books, co-author and contributor, publications, booklet, handbook for teachers in secondary schools, articles and book reviews. Chapter Three consists of a brief individual summary of the three significant books of Prof. Davison; with the articles and the Turkish translation has been introduced respectively. Chapter Four consists of the contributions of Prof. Roderic Davison to the Ottoman and the Turkish history. "Why is the Treaty of Kuchuk Kainardji Important?" The answer and the clarification of Kuchuk Kainardji has been searched by comparing with the contemporary Turkish historians and Davison as well. Chapter Five consists of the articles of Prof. Roderic Davison's that translated into Turkish language in Turkey. In addition to those translations, a brand new translation of the "The 'Dosografa' Church in the Treaty of Kuchuk Kainardji" has been made by the author to support the question of "Why is the Treaty of Kuchuk Kainardji Important?" Chapter Six consists of the Memoriam, An Appreciation and Interviews with his colleagues, friends and Turkish students of late Prof. Davison. In addition, we provided the original documents and the charts related with the subject in appendices as far as possible from the concerned educational institutions and organizations. I
Life or death for Oregon
No full textA call to arms by Governor C. A. Sprague at the Keep Oregon Green organization dinner -- An address by Roderic Olzendam at the Keep Oregon Green Dinner, April 28, 1941.This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from cover.On back cover: The creed of the Oregon woodsman.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Low flow hydrology: application of a systems approach
No full textDeposited with permission of the author. © 1990 Roderic John Nathan.Australia is not only the driest continent, but its streams are among the most variable in the world. To date in Australia there has been no large-scale study of Australia’s low flow hydrologic characteristics, and consequently there is a fundamental need to develop methods that can be readily used to assess the hydrology during times of low flow. This thesis describes the development and derivation of a methodology for the estimation of low flow characteristics and yield in small ungauged rural catchments. The methodology has been applied to 184 catchments located in New South Wales and Victoria, in south-eastern Australia. A systems approach was adopted in which multivariate techniques were used to develop relationships between low flow parameters and climatic and land information data. The low flow and yield parameters considered include: descriptive statistics of monthly and annual flows, ratio of baseflow to total streamflow volumes, streamflow recession constants, flow duration curves for daily, monthly and annual durations, low flow frequency curves for durations from 1 to 284 days, duration of low flow spells below a given threshold, deficiency volume of low flow spells below a given threshold, estimate of storage to satisfy a specified draft at a given level of reliability, and parameters of a simple rainfall-runoff model for conversion of daily rainfall to monthly streamflow volumes
From risk modification to precision therapy : integrated strategies for enhancing cancer prevention and treatment
No full textEl càncer de mama és el càncer diagnosticat amb més freqüència i la principal causa de mort relacionada amb el càncer entre les dones a nivell mundial. Les alteracions genètiques hereditàries (germinals) i adquirides (somàtiques) contribueixen al desenvolupament de la malaltia. Les variants patogèniques en els gens de susceptibilitat al càncer de mama BRCA1 i BRCA2 s'associen a un alt risc de càncer i defineixen tumors amb característiques moleculars i vulnerabilitats específiques. Tanmateix, els determinants genètics germinals de l'inici del càncer no es comprenen completament, i els factors biològics somàtics que influeixen en la progressió del càncer i en la resposta als tractaments encara no han estan del tot definits. Abordar aquestes llacunes en el coneixement podria millorar els esforços de prevenció primària i optimitzar les estratègies de tractament personalitzat. Aquesta tesi té com a objectiu explorar com els modificadors genètics i els trets immunitaris contribueixen al risc de càncer de mama, amb la finalitat d'identificar possibles biomarcadors precoços de la malaltia i determinants d'una característica somàtica clau dels tumors corresponents-impulsada per una activitat diferencial en els processos de reparació del dany a l'ADN-que estan vinculats a vulnerabilitats terapèutiques. En primer lloc, vam analitzar estadístiques de GWAS i perfils transcriptòmics de tumors, i vam validar HMMR com a modificador de risc del càncer de mama associat a BRCA1 en demostrar el seu paper en l'augment de la inestabilitat genòmica. Separadament, vam identificar 4.093 variants genètiques de pleiotropia que associen trets hematològics amb el risc de càncer, i vam trobar un enriquiment significatiu a prop de loci de Y-RNA. A partir d'aquesta observació, vam establir el Y-RNA com un possible biomarcador en plasma, indicat per un augment del risc de càncer de mama. A continuació, vam proposar una nova estratègia terapèutica dirigida tant a hipòxia com a la via d'unió d'extrems alternativa (alternative end-joining), essencials per a la supervivència de les cèl·lules canceroses amb mutacions a BRCA1/BRCA2. En concret, el bloqueig de HIF1α-un regulador clau de la hipòxia-fa que les cèl·lules siguin més vulnerables a la inhibició de PARP o POLQ, independentment de l'estat de recombinació homòloga. Finalment, per fer possible la translació clínica, vam entrenar models d'aprenentatge profund que avaluaven l'activitat de les vies d'unió d'extrems alternativa i de la hipòxia mitjançant imatges patològiques tumorals, oferint un mètode de precisió assistit per IA per a l'estratificació de pacients. En conjunt, aquests resultats amplien el coneixement sobre la biologia del càncer de mama, proporcionen nous objectius terapèutics i permeten enfocaments clínics més precisos.El cáncer de mama es el cáncer más diagnosticado y la principal causa de muerte relacionada con el cáncer en mujeres a nivel mundial. Las alteraciones genéticas heredadas (germinales) y adquiridas (somáticas) contribuyen al desarrollo de la enfermedad. Las variantes patogénicas en los genes de susceptibilidad al cáncer de mama BRCA1 y BRCA2 están asociadas con un alto riesgo de cáncer y definen tumores con características moleculares y vulnerabilidades específicas. Sin embargo, los determinantes genéticos germinales del inicio del cáncer no se comprenden completamente, y las características biológicas somáticas que influyen en la progresión del cáncer y los resultados terapéuticos aún no están completamente caracterizados. Abordar estas brechas de conocimiento podría mejorar los esfuerzos de prevención primaria y optimizar las estrategias de tratamiento personalizado. Esta tesis tuvo como objetivo explorar cómo los modificadores genéticos y los rasgos del sistema inmunitario contribuyen al riesgo de cáncer de mama, con el fin de identificar posibles biomarcadores tempranos de la enfermedad y determinantes de una característica somática clave en los tumores correspondientes-impulsada por una actividad diferencial en los procesos de reparación del daño en el ADN-que están vinculados a vulnerabilidades terapéuticas. En primer lugar, analizamos datos de GWAS y perfiles transcriptómicos de tumores, y validamos a HMMR como un modificador de riesgo en el cáncer de mama asociado a BRCA1, al demostrar su papel en el aumento de la inestabilidad genómica. Por separado, identificamos 4.093 variantes genéticas de pleiotropía que asocian rasgos hematológicos con el riesgo de cáncer, y encontramos un enriquecimiento significativo cerca de loci de Y-RNA. A partir de esta observación, establecimos al Y-RNA como un posible biomarcador plasmático, indicado por un mayor riesgo de cáncer de mama. A continuación, propusimos una nueva estrategia terapéutica dirigida tanto a la hipoxia como a las vías de unión alternativa de extremos (alternative end-joining), crítica para la supervivencia de células cancerosas con mutaciones en BRCA1/BRCA2. Específicamente, el bloqueo de HIF1α-regulador clave de la hipoxia-hace que las células sean más vulnerables a la inhibición de PARP o POLQ, independientemente del estado de recombinación homóloga. Finalmente, para habilitar la aplicación clínica, entrenamos modelos de aprendizaje profundo que evaluaron la actividad de las vías de unión alternativa de extremos y de hipoxia utilizando imágenes patológicas de tumores, ofreciendo un método de precisión asistido por IA para la estratificación de pacientes. En conjunto, estos hallazgos amplían el conocimiento sobre la biología del cáncer de mama, proporcionan nuevos objetivos terapéuticos y permiten enfoques clínicos más precisos.Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer-related death among women worldwide. Inherited (germline) and acquired (somatic) genetic alterations contribute to disease development. Pathogenic variants in the breast cancer susceptibility genes BRCA1 and BRCA2 are associated with a high risk of cancer and define tumors with specific molecular features and vulnerabilities. However, the germline genetic determinants of cancer initiation are not fully understood, and the somatic biological features that influence cancer progression and therapeutic outcomes remain incompletely characterized. Addressing these knowledge gaps could enhance primary preventive efforts and improve personalized treatment strategies. This thesis aimed to explore how genetic modifiers and immune traits contribute to breast cancer risk, with the goal of identifying potential early disease biomarkers determinants of a key somatic feature of the corresponding tumors-driven by differential activity in DNA damage repair processes-which are linked to therapeutic vulnerabilities. First, we analyzed GWAS summary statistics and transcriptomic profiles from tumors and we validated HMMR as a risk modifier of BRCA1-associated breast cancer by demonstrating its role in enhancing genomic instability. Separately, we identified 4,093 pleiotropy genetic variants associating blood traits with cancer risk, and found a significant enrichment near Y-RNA loci. Based on this observation, we then established Y-RNA as a possible biomarker in plasma, indicated by an increased risk of breast cancer. Next, we proposed a novel therapeutic strategy that targets both the hypoxia and alternative end-joining pathways, which is critical for the survival of BRCA1/BRCA2-mutant cancer cells. Specifically, blocking HIF1a-key regulator of hypoxia-rendering cells more vulnerable to PARP or POLQ inhibition, regardless of homologous recombination status. Finally, to enable clinical translation, we trained deep-learning models that assessed the activity of alternative end-joining and hypoxia pathways by using tumor pathology images, offering an AI-assisted precision method for patient stratification. Together, these findings advance breast cancer biology knowledge, providing novel therapeutic targets, and enable more precise, clinical approaches
Rod Korns
No full textPhoto showing J. Roderic ("Rod") Korns, a historian of western trails and author of "West from Fort Bridger
#1145 Middle East Report - 1968.
No full textParticipants include: Mr. William Sands, Executive Director, Middle East Institute; and Editor of the Middle East Journal Dr. Hisham Sharabi, Professor of History, Georgetown University; and author of the forthcoming book: U.S. Involvement in the Arab World Dr. Roderic H. Davison, Professor of History, The George Washington University; and author of the history: TurkeyDate on tape:10/22/1968
BioGUID: resolving, discovering, and minting identifiers for biodiversity informatics
No full text<b>Background</b>: Linking together the data of interest to biodiversity researchers (including specimen records, images, taxonomic names, and DNA sequences) requires services that can mint, resolve, and discover globally unique identifiers (including, but not limited to, DOIs, HTTP URIs, and LSIDs).
<b>Results</b>: BioGUID implements a range of services, the core ones being an OpenURL resolver for bibliographic resources, and a LSID resolver. The LSID resolver supports Linked Data-friendly resolution using HTTP 303 redirects and content negotiation. Additional services include journal ISSN look-up, author name matching, and a tool to monitor the status of biodiversity data providers.
<b>Conclusion</b>: BioGUID is available at http://bioguid.info/. Source code is available from http://code.google.com/p/bioguid/
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