164 research outputs found
Antti Arjava et alii, The Petra Papyri III. Edited by Antti Arjava, Matias Buchholz, and Traianos Gagos, with Contributions by Robert C. Caldwell, Robert W. Daniel, Ludwig Koenen, Marjo Lehtinen (†), Mari Mikkola, Mari Mustonen, Tiina Purola, Erja Salmenkivi, Marjaana Vesterinen, and Marja Vierros, and Plates prepared by Terrence Szymanski and Vesa Vahtikari
No full textAntti Arjava et alii, The Petra Papyri III. Edited by Antti Arjava, Matias Buchholz, and Traianos Gagos, with Contributions by Robert C. Caldwell, Robert W. Daniel, Ludwig Koenen, Marjo Lehtinen (†), Mari Mikkola, Mari Mustonen, Tiina Purola, Erja Salmenkivi, Marjaana Vesterinen, and Marja Vierros, and Plates prepared by Terrence Szymanski and Vesa Vahtikari. In: Revue des études byzantines, tome 66, 2008. pp. 309-310
Antti Arjava et alii, The Petra Papyri III. Edited by Antti Arjava, Matias Buchholz, and Traianos Gagos, with Contributions by Robert C. Caldwell, Robert W. Daniel, Ludwig Koenen, Marjo Lehtinen (†), Mari Mikkola, Mari Mustonen, Tiina Purola, Erja Salmenkivi, Marjaana Vesterinen, and Marja Vierros, and Plates prepared by Terrence Szymanski and Vesa Vahtikari
No full textAntti Arjava et alii, The Petra Papyri III. Edited by Antti Arjava, Matias Buchholz, and Traianos Gagos, with Contributions by Robert C. Caldwell, Robert W. Daniel, Ludwig Koenen, Marjo Lehtinen (†), Mari Mikkola, Mari Mustonen, Tiina Purola, Erja Salmenkivi, Marjaana Vesterinen, and Marja Vierros, and Plates prepared by Terrence Szymanski and Vesa Vahtikari. In: Revue des études byzantines, tome 66, 2008. pp. 309-310
Telephone-based health coaching for chronic disease patients: evaluation of short- and long-term effectiveness of health benefits and costs
No full textThe expression of novel, load-induced extracellular matrix modulating factors in cardiac remodeling
No full textAbstractCardiac remodeling is defined as changes in the size, shape and function of the heart, caused most commonly by hypertension-induced left ventricular (LV) hypertrophy and myocardial infarction (MI). It is characterized by changes in cellular and extracellular compartments regulated by e.g. neurohumoral and inflammatory factors. In the present study the expression of novel, load induced factors, thrombospondin (TSP)-1 and -4, matrix Gla protein (MGP), tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14, was investigated during cardiac remodeling. Their expression in the heart was characterized using experimental models of pressure overload, hypertensive hypertrophy and MI, and the effect of hypertrophic agonists and cellular stretch was studied in vitro. The effect of beta-blocker treatment on TSP expression was also examined. TSP-1 and -4 were rapidly upregulated in response to pressure overload, and the induction of TSP-4 gene expression was attenuated in hypertrophied heart. After MI, TSP-1 and -4 mRNA and TSP-1 protein levels were increased, and the induction was attenuated by metoprolol. TSP-1 and -4 expression correlated with natriuretic peptide expression and LV remodeling after MI. In hypertensive hypertrophy, only TSP-4 expression decreased after metoprolol treatment and was correlated with LV remodeling. MGP gene expression was increased in response to pressure overload and MI both in the early and late phase of cardiac remodeling. MGP protein levels were increased in the acute phase of post-MI remodeling and in hypertensive hypertrophy. In vitro, angiotensin II increased MGP gene expression in myocytes and fibroblasts, whereas expression decreased in response to mechanical stretch. In response to increased cardiac load Fn14 expression was upregulated both acutely and chronically while TWEAK expression remained relatively constant. Fn14 localized mainly to fibroblasts in the inflammatory area while TWEAK localized to myocytes and endothelial cells. In myocytes, Fn14 expression was induced by hypertrophic agonists and mechanical stretch in contrast to stabile or decreased TWEAK expression. This study provides new insights into the expression of the studied novel factors in cardiac remodeling. The distinct expression of TSPs in pressure overload and post-MI suggests that TSP-1 and -4 may have unique roles in the remodeling process. The results also imply that MGP is part of the common gene program of hypertrophic remodeling in vivo and contributes to the molecular basis of cardiac hypertrophy. Finally, the study demonstrates differential regulation of TWEAK and Fn14 expression in the heart and emphasizes the importance of Fn14 as a mediator of TWEAK/Fn14 signaling and as a potential target of therapeutic interventions. Academic dissertation to be presented with the assent of the Faculty of Medicine of the University of Oulu for public defence in the Auditorium of the Department of Pharmacology and Toxicology, on 17 September 2010, at 12 noonAbstract
Cardiac remodeling is defined as changes in the size, shape and function of the heart, caused most commonly by hypertension-induced left ventricular (LV) hypertrophy and myocardial infarction (MI). It is characterized by changes in cellular and extracellular compartments regulated by e.g. neurohumoral and inflammatory factors. In the present study the expression of novel, load induced factors, thrombospondin (TSP)-1 and -4, matrix Gla protein (MGP), tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14, was investigated during cardiac remodeling. Their expression in the heart was characterized using experimental models of pressure overload, hypertensive hypertrophy and MI, and the effect of hypertrophic agonists and cellular stretch was studied in vitro. The effect of beta-blocker treatment on TSP expression was also examined.
TSP-1 and -4 were rapidly upregulated in response to pressure overload, and the induction of TSP-4 gene expression was attenuated in hypertrophied heart. After MI, TSP-1 and -4 mRNA and TSP-1 protein levels were increased, and the induction was attenuated by metoprolol. TSP-1 and -4 expression correlated with natriuretic peptide expression and LV remodeling after MI. In hypertensive hypertrophy, only TSP-4 expression decreased after metoprolol treatment and was correlated with LV remodeling.
MGP gene expression was increased in response to pressure overload and MI both in the early and late phase of cardiac remodeling. MGP protein levels were increased in the acute phase of post-MI remodeling and in hypertensive hypertrophy. In vitro, angiotensin II increased MGP gene expression in myocytes and fibroblasts, whereas expression decreased in response to mechanical stretch.
In response to increased cardiac load Fn14 expression was upregulated both acutely and chronically while TWEAK expression remained relatively constant. Fn14 localized mainly to fibroblasts in the inflammatory area while TWEAK localized to myocytes and endothelial cells. In myocytes, Fn14 expression was induced by hypertrophic agonists and mechanical stretch in contrast to stabile or decreased TWEAK expression.
This study provides new insights into the expression of the studied novel factors in cardiac remodeling. The distinct expression of TSPs in pressure overload and post-MI suggests that TSP-1 and -4 may have unique roles in the remodeling process. The results also imply that MGP is part of the common gene program of hypertrophic remodeling in vivo and contributes to the molecular basis of cardiac hypertrophy. Finally, the study demonstrates differential regulation of TWEAK and Fn14 expression in the heart and emphasizes the importance of Fn14 as a mediator of TWEAK/Fn14 signaling and as a potential target of therapeutic interventions
Uuvutetaan uupumus, sytytetään suorituskyky : valmennusmalli yrittäjien arjen ja työn tasapainoon
No full textTIIVISTELMÄ
Oulun ammattikorkeakoulu
Johtaminen ja työhyvinvointi
Tekijä: Ilkka Mustonen
Opinnäytetyön otsikko: Uuvutetaan uupumus, sytytetään suorituskyky
Työn ohjaaja: Hanna Okkonen
Työn valmistumislukukausi ja -vuosi: kevät 2025
Sivumäärä: 105
Tämän opinnäytetyön tavoitteena oli kehittää “Intoa arkeen” -valmennusmalli,
joka tukee yrittäjien hyvinvointia ja suorituskykyä kokonaisvaltaisesti. Työ sai
alkunsa tarpeesta vastata yrittäjien kuormittuneisuuteen ja palautumisen
haasteisiin, joita usein kohdataan ilman ulkopuolista tukea. Tavoitteena oli
rakentaa käytännönläheinen ja yksilölähtöinen malli, joka huomioi arjen
todelliset vaatimukset.
Tietoperusta pohjautui useisiin hyvinvoinnin ja suorituskyvyn teorioihin, kuten
Hettlerin kuusiulotteiseen hyvinvointimalliin, 7DHW-malliin, resilienssiteoriaan,
itsemyötätuntoon sekä kokemukselliseen valmennusotteeseen. Näiden pohjalta
muodostettiin viitekehys, joka ohjasi mallin sisältöjä ja rakennetta.
Tutkimusmenetelmänä käytettiin integratiivista kirjallisuuskatsausta, joka
mahdollisti teoreettisen ja empiirisen tiedon yhdistämisen. Kehittämisprosessia
täydensivät keskustelut yrittäjien, valmennusasiakkaiden ja rahoittajien kanssa,
mikä vahvisti mallin käytännön sovellettavuutta.
Lopputuloksena syntyi kuuteen moduuliin jakautuva valmennusmalli, joka
käsittelee arvoja, minäkuvaa, motivaatiota, ajanhallintaa, palautumista ja
fyysistä hyvinvointia. Moduulit sisältävät teoriaosuuksia, harjoituksia ja työkaluja
arjen muutoksen tueksi.
Kokonaisuutena valmennusmalli tarjoaa sovellettavan ja uskottavan keinon
yrittäjien hyvinvoinnin tukemiseen. Jatkokehitykseksi esitetään mallin pilotointia
ja vaikuttavuuden arviointia käytännön valmennustilanteissa.ABSTRACT
Oulu University of Applied Sciences
Leadership and occupational well-being
Author: Ilkka Mustonen
Title of thesis: Extinguishing fatigue, igniting performance
Supervisor: Hanna Okkonen
Term and year when the thesis was submitted: Spring 2025
Number of pages: 105
The aim of this thesis was to develop the “Intoa arkeen” coaching model to
comprehensively support the well-being and performance of entrepreneurs. The
work was initiated in response to the growing need to address the overload and
recovery challenges entrepreneurs face—often without external support. The
goal was to create a practical and individual-centered model that takes into
account the real demands of everyday life.
The theoretical foundation was based on multiple well-being and performance
frameworks, including Hettler’s six-dimensional wellness model, the 7DHW
model, resilience theory, self-compassion, and an experiential coaching
approach. These perspectives formed a conceptual framework that guided the
content and structure of the coaching model.
An integrative literature review was used as the research method, enabling the
combination of theoretical and empirical sources. The development process
was enriched by discussions with entrepreneurs, coaching clients, and funding
stakeholders, which helped ensure the model’s practical relevance.
The resulting coaching model consists of six modules addressing values, self-
concept, motivation, time management, recovery, and physical well-being. Each
module includes theoretical components, exercises, and tools to support
practical change in everyday life.
Overall, the model provides an applicable and credible approach to supporting
entrepreneurial well-being. As a next step, pilot implementation and impact
evaluation in real-life coaching settings are recommended
Information System ProcessInnovation Adoption, Adaptation, Learning, and Unlearning: A Longitudinal Case Study
No full textThis thesis examines the history and evolution of information system process innovation (ISPI) processes (adoption, adaptation, and unlearning) within the information system development (ISD) work in an internal information system (IS) department and in two IS software house organisations in Finland over a 43-year time-period. The study offers insights into influential actors and their dependencies in deciding over ISPIs. The research usesa qualitative research approach, and the research methodology involves the description of the ISPI processes, how the actors searched for ISPIs, and how the relationships between the actors changed over time. The existing theories were evaluated using the conceptual models of the ISPI processes based on the innovationliterature in the IS area. The main focus of the study was to observe changes in the main ISPI processes over time. The main contribution of the thesis is a new theory. The term theory should be understood as 1) a new conceptual framework of the ISPI processes, 2) new ISPI concepts and categories, and the relationships between the ISPI concepts inside the ISPI processes. The study gives a comprehensive and systematic study on the history and evolution of the ISPI processes; reveals the factors that affected ISPI adoption; studies ISPI knowledge acquisition, information transfer, and adaptation mechanisms; and reveals the mechanismsaffecting ISPI unlearning; changes in the ISPI processes; and diverse actors involved in the processes. The results show that both the internal IS department and the two IS software houses sought opportunities to improve their technical skills and career paths and this created an innovative culture. When new technology generations come to the market the platform systems need to be renewed, and therefore the organisations invest in ISPIs in cycles. The extent of internal learning and experiments was higher than the external knowledge acquisition. Until the outsourcing event (1984) the decision-making was centralised and the internalIS department was very influential over ISPIs. After outsourcing, decision-making became distributed between the two IS software houses, the IS client, and itsinternal IT department. The IS client wanted to assure that information systemswould serve the business of the company and thus wanted to co-operate closely with the software organisations.ei tietoa saavutettavuudest
Methodologies Choice and Adoption: Using Diffusion of Innovations as the Theoretical Framework
No full textThis goal of this paper is to represent the method choice and adoption factors in two organizations over the 43 years period. General theoretical framework, chosen research approach, the research problems concerning method choice, implementation and use (adoption), the research methodology, related research and historical background of the organizations are represented. Methods for validity and reliability checking of the data sources are checked. The method choice using the theory of Diffusion of Innovations is taken as a focal point in this research
The expression of novel, load-induced extracellular matrix modulating factors in cardiac remodeling
No full textAbstract
Cardiac remodeling is defined as changes in the size, shape and function of the heart, caused most commonly by hypertension-induced left ventricular (LV) hypertrophy and myocardial infarction (MI). It is characterized by changes in cellular and extracellular compartments regulated by e.g. neurohumoral and inflammatory factors. In the present study the expression of novel, load induced factors, thrombospondin (TSP)-1 and -4, matrix Gla protein (MGP), tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14, was investigated during cardiac remodeling. Their expression in the heart was characterized using experimental models of pressure overload, hypertensive hypertrophy and MI, and the effect of hypertrophic agonists and cellular stretch was studied in vitro. The effect of beta-blocker treatment on TSP expression was also examined.
TSP-1 and -4 were rapidly upregulated in response to pressure overload, and the induction of TSP-4 gene expression was attenuated in hypertrophied heart. After MI, TSP-1 and -4 mRNA and TSP-1 protein levels were increased, and the induction was attenuated by metoprolol. TSP-1 and -4 expression correlated with natriuretic peptide expression and LV remodeling after MI. In hypertensive hypertrophy, only TSP-4 expression decreased after metoprolol treatment and was correlated with LV remodeling.
MGP gene expression was increased in response to pressure overload and MI both in the early and late phase of cardiac remodeling. MGP protein levels were increased in the acute phase of post-MI remodeling and in hypertensive hypertrophy. In vitro, angiotensin II increased MGP gene expression in myocytes and fibroblasts, whereas expression decreased in response to mechanical stretch.
In response to increased cardiac load Fn14 expression was upregulated both acutely and chronically while TWEAK expression remained relatively constant. Fn14 localized mainly to fibroblasts in the inflammatory area while TWEAK localized to myocytes and endothelial cells. In myocytes, Fn14 expression was induced by hypertrophic agonists and mechanical stretch in contrast to stabile or decreased TWEAK expression.
This study provides new insights into the expression of the studied novel factors in cardiac remodeling. The distinct expression of TSPs in pressure overload and post-MI suggests that TSP-1 and -4 may have unique roles in the remodeling process. The results also imply that MGP is part of the common gene program of hypertrophic remodeling in vivo and contributes to the molecular basis of cardiac hypertrophy. Finally, the study demonstrates differential regulation of TWEAK and Fn14 expression in the heart and emphasizes the importance of Fn14 as a mediator of TWEAK/Fn14 signaling and as a potential target of therapeutic interventions
IS Process Innovation Unlearning in Organizations
No full textThis paper identifies mechanisms that affected over 200 Information System Process Innovation (ISPI) unlearning decisions in three organisational environments over a period that spanned four decades. The analysis is based on previous unlearning studies. Four distinct generations analysed are early computing (1954-1965); main frame era (1965-1983); office computing era (1983-1991), and distributed applications era (1991-1997). These follow roughly Friedman’s and Cornford’s categorisation of IS development eras. We also distinguish four types of ISPI’s: base line technologies, development tools, description methods, and managerial process innovations. Our analysis shows that the most important unlearning mechanisms were new knowledge creation, poor performance, react to changing environment, changes in management, and too complicated to use. In the organisations the unlearning mechanisms varied significantly according to the ISPI category, and time generation. The variation can be thus partly explained by the fact that the technological development and the rapid diffusion of microcomputers in the beginning of 1980s changed IS development (ISD) work, and new skills and ISPIs were needed. In the beginning of 1990s technological platforms, operating systems, databases, tools, and working procedures changed to object orientation, and the previous ISPIs had to be unlearned
Historical Research in Information System Field: from Data Collection to Theory Creation
No full textThis paper gives important methodological, theoretical, and practical guidelines to the information system (IS) researchers to carry out a historical study. This study shows how a new theory can be discovered inductively from historical studies using a methodological guideline from Mason et al. (1997b); using multiple data collection methods, such as semi-structured interviews, archival files, and published news; and using novel data analysis methods from learning and intelligent systems, such as the Self-Organizing Maps (SOMs), SOMs combined with U-matrices, and the Bayesian network modeling. It also outlines the benefits, the main problems, the characteristics, and the implications of historical research in the information system field. Finally this paper gives future some research directions of historical research.JRC.G.4 - Maritime affair
- …
