116,628 research outputs found
Cortical neuronal loss and hippocampal sclerosis are not detected by voxel-based morphometry in individual epilepsy surgery patients
No full textVoxel-based morphometry (VBM) has detected differences between brains of groups of patients
with epilepsy and controls, but the sensitivity for detecting subtle pathological changes in single subjects
has not been established. The aim of the study was to test the sensitivity of VBM using statistical parametric
mapping (SPM5) to detect hippocampal sclerosis (HS) and cortical neuronal loss in individual patients.
T1-weighted volumetric 1.5 T MR images from 13 patients with HS and laminar cortical neuronal loss
were segmented, normalised and smoothed using SPM5. Both modulated and non-modulated analyses
were performed. Comparisons of one control subject against the rest (n ¼ 23) were first performed to ascertain
the smoothing level with the lowest number of SPM changes in controls. Each patient was then compared
against the whole control group. The lowest number of SPM changes in control subjects was found
at a smoothing level of 10 mm full width half maximum for modulated and non-modulated data. In the
patient group, no SPM abnormalities were found in the affected temporal lobe or hippocampus at this
smoothing level. At lower smoothing levels there were numerous SPM findings in controls and patients.
VBM did not detect any abnormalities associated with either laminar cortical neuronal loss or HS. This
may be due to normalisation and smoothing of images and low statistical power in areas with larger interindividual
differences. This suggests that the methodology may currently not be suitable to detect particular
occult abnormalities possibly associated with seizure onset zone in individual epilepsy patients with
unremarkable standard structural MRI
How Many Danish Jobs Can (Potentially) Be Done Elsewhere?
No full textThis paper employs a new survey technique to arrive at estimates of the proportion of jobs with the characteristic that they can be performed elsewhere than currently, in particular in other countries. The results from the survey which was carried out in November 2008 indicate that the proportion of current jobs with offshorability characteristics in Denmark is in the 20 to 30 percent range. Danish jobs that could potentially be carried out elsewhere are primarily found in the services sector (financial and business services) and they are typically performed by employees from the middle of the wage distributionJobs; offshorability; outsourcing
Circadian rhythm and epilepsy
No full textAdvances in diagnostic technology, including chronic intracranial EEG recordings, have confirmed the clinical observation of different temporal patterns of epileptic activity and seizure occurrence over a 24-h period. The rhythmic patterns in epileptic activity and seizure occurrence are probably related to vigilance states and circadian variation in excitatory and inhibitory balance. Core circadian genes BMAL1 and CLOCK, which code for transcription factors, have been shown to influence excitability and seizure threshold. Despite uncertainties about the relative contribution of vigilance states versus circadian rhythmicity, including circadian factors such as seizure timing improves sensitivity of seizure prediction algorithms in individual patients. Improved prediction of seizure occurrence opens the possibility for personalised antiepileptic drug-dosing regimens timed to particular phases of the circadian cycle to improve seizure control and to reduce side-effects and risks associated with seizures. Further studies are needed to clarify the pathways through which rhythmic patterns of epileptic activity are generated, because this might also inform future treatment options
Drepanoistodus iommii Rasmussen & Eriksson & Lindskog 2021, sp. nov.
No full textDrepanoistodus iommii sp. nov. urn:lsid:zoobank.org:act: 0E2832F5-672E-4FAE-B5A5-CBA5DE1A4824 Fig. 6E–H partim Drepanoistodus aff. basiovalis – Mellgren & Eriksson 2010: fig. 7m (only). Drepanoistodus cf. basiovalis – Mellgren et al. 2012: fig. 5e. Diagnosis A Drepanoistodus species characterised by a geniculate element with distinct keels on the cusp and upper margin of the base; a straight basal margin; a straight to weakly rounded (convex) anterior margin and cusp which is approximately twice the length of the upper margin of the base. Etymology Named in honour of legendary guitarist Tony Iommi, founding member of heavy metal band Black Sabbath. Material examined Ten geniculate elements including eight from the Lynna section. Holotype, geniculate element (Fig. 6E–F); LO 12479T. Type locality River bank near the mouth of Lynna River, village of Kolchanovo, St. Petersburg region, Russia (60°00′39″ N, 32°33′49″ E). Type stratum Approximately 10 cm above the local base of the Lynna Formation, sample LY 12-16. Lower part of the Lenodus variabilis Zone. Description Cusp reclined and straight with distinct keels developed on the anterior (upper) and posterior (lower) margins. A median, longitudinal carina is developed on both sides of the cusp, but it is especially distinct on the inner side. Base is characterised by a straight or almost straight basal margin and a distinct keel on the upper margin. Whereas this keel is slightly convex, the upper margin below the keel is straight. Anterior margin is usually straight or weakly rounded (convex), but occasionally, it is strongly rounded. Angle A between the cusp and upper margin of the base is ca 30° (mean) with a standard deviation at 4.2 (Fig. 5B), and the mean ratio between length of the free upper margin (b) and the free cusp (c) is 0.54 (standard deviation 0.10). Remarks In the PCA plot (Fig. 4), the population of D. iommii sp. nov. is situated in the upper right corner, separated from the D. basiovalis population as well as the other two new species populations described herein. The vectors in the biplot demonstrate that this is mainly due to the straight basal margin, the relatively long upper margin (high b/c values), and the usually straight anterior margin in D. iommii sp. nov., which is in accordance with the characters diagnosed above. The hypothesis that the population of D. iommii sp. nov. is morphologically different from the D. basiovalis population is supported by the PERMANOVA test (Fig. 5A), which shows that the probability that the two populations are the same is exceedingly low (p (same) = 1.00E- 04). Occurrence The L. antivariabilis Zone (sample LY12-9) to the L. variabilis Zone (sample LY12-21b). Outside the St. Petersburg region, D. iommii sp. nov. has been recorded from the L. variabilis Zone at the Hällekis quarry in Västergötland, Sweden (Mellgren & Eriksson 2010; referred to as D. aff. basiovalis) and from the L. pseudoplanus Zone or E. suecicus Zone of the island Osmussaar, Estonia (Mellgren et al. 2012; reported as D. cf. basiovalis).Published as part of Rasmussen, Jan Audun, Eriksson, Mats E. & Lindskog, Anders, 2021, Middle Ordovician Drepanoistodus (Vertebrata, Conodonta) from Baltica, with description of three new species, pp. 106-134 in European Journal of Taxonomy 774 on pages 119-120, DOI: 10.5852/ejt.2021.774.1533, http://zenodo.org/record/555714
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Foreign Ownership Wage Premia in Emerging Economies: Evidence from Czech Republic
No full textIn this paper we examine the relationship between wages, labour productivity and ownership using a linked employer-employee dataset covering a large fraction of the Czech labour market in 2006. We distinguish between different origins of ownership and study wage and productivity differences. The raw wage differential between foreign and domestically owned firms is about 24 percent. The empirical analysis is carried out on both firm- and individual-level data. A key finding is that industry, region, and notably human capital explain only a small part of the foreign-domestic ownership wage differential. Both white and blue collar workers as well as skilled and unskilled employees obtain a foreign ownership wage premium. Foreign ownership premia are more prevalent in older and less technologically advanced firms. Joint estimation of productivity and wage equations show that, controlling for human capital, the difference in productivity is about twice as large as the wage differential. The results indicate that the international firms share their rents with their employeesForeign ownership; wages; productivity
Narkomanvården vid Ulleråkers narkomanvårdsklinik
No full textNarkomanvård har sedan 1966 förekommit vid forskningsavdelningen vid Ulleråkers sjukhus. Sedan 1967 har vården ägt rum vid en specialavdelning. Vårdens utformning vid denna avdelning har fortlöpande förändrats. En rad behandlingsmetoder har systematiskt etablerats både vad gäller medicinsk och individualpsykologisk behandling och miljöterapi.De nuvarande behandlingsprinciperna beskrives i nedanstående artikel av bitr överläkarna Jan H. Eriksson och K. Gunnar Götestam, båda verksamma vid Ulleråkers sjukhus forskningsavdelning
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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