1,069 research outputs found
Transdermal hormonal therapy in perimenstrual migraine: why, when and how?
No full textExperimental and clinical evidence is strongly in favor of a role for estrogens in migraine. It is clear that estrogen fluctuations represent trigger factors for the attacks, while the resolution of these fluctuations (menopause) may be associated to the remission or, conversely, to the worsening of the disease. However, the exact mechanisms and mediators underlying the effects of estrogens in migraine are largely unknown. The exact mechanisms and mediators underlying the effects of estrogens in migraine are largely unknown. In this review, we summarize clinical and preclinical data that are relevant for the role of estrogens in migraine and we discuss how estrogen modulation can be exploited positively to improve hormonal-related migraine
Hormonal contraception in women with migraine: is progestogen-only contraception a better choice?
No full textA significant number of women with migraine has to face the choice of reliable hormonal contraception during their fertile life. Combined hormonal contraceptives (CHCs) may be used in the majority of women with headache and migraine. However, they carry a small, but significant vascular risk, especially in migraine with aura (MA) and, eventually in migraine without aura (MO) with additional risk factors for stroke (smoking, hypertension, diabetes, hyperlipidemia and thrombophilia, age over 35 years). Guidelines recommend progestogen-only contraception as an alternative safer option because it does not seem to be associated with an increased risk of venous thromboembolism (VTE) and ischemic stroke.
Potentially, the maintenance of stable estrogen level by the administration of progestins in ovulation inhibiting dosages may have a positive influence of nociceptive threshold in women with migraine. Preliminary evidences based on headache diaries in migraineurs suggest that the progestin-only pill containing desogestrel 75 μg has a positive effect on the course of both MA and MO in the majority of women, reducing the number of days with migraine, the number of analgesics and the intensity of associated symptoms. Further prospective trials have to be performed to confirm that progestogen-only contraception may be a better option for the management of both migraine and birth control. Differences between MA and MO should also be taken into account in further studies
Erica versicolor
No full textTavola tratta da: Piante del R. Orto di Padova
Erica versicolor Andr.
Ericaceae
erica
Le Eriche sono piante perenni e legnose, alcune di modeste dimensioni (15-20 cm) altre di qualche metro, con portamento arboreo. Hanno foglie persistenti, in verticilli di tré-sei, aghiformi o raramente appiattite. I fiori, isolati o riuniti in infiorescenze, hanno un calice suddiviso (vedi particolare della tavola) più piccolo, anche di molto, della corolla che in alcune specie misura fino a quattro centimetri. Questa poi è sempre gamopetala, o tubulosa, come nell\u27Erica della figura, o campanulata o "urceolata", cioè a forma di piccolo orcio com\u27è nella nostrana Erica erbacea. Il nome Erica forse è antico, ma il primo a usarlo con valore di genere fu Joseph Pittori deTournefort (656-708). Il valore ornamentale delle Eriche non è molto apprezzato in Italia, a differenza di quanto avviene in altri paesi, come Inghilterra e Germania. Ciò può essere determinato da cause genericamente culturali, ma anche da motivi storici e ambientali (la maggior parte delle Eriche vuole terreno acido e quelle nordiche richiedono una maggior umidità rispetto a quelle mediterranee). Fu nella seconda metà del \u27700 che molte Eriche arrivarono in Inghilterra, soprattutto dal Sud Africa, come l\u27Erica di questa tavola, un cespuglio alto fino a tre metri, Nel catalogo dell\u27Orto botanico di Padova del 1820 sono elencate sette specie, ma ben ventisette, compresa questa tavola, sono quelle raffigurate nella nostra raccolta iconografica.tempera su cart
Effect of a contraceptive pill containing estradiol valerate and dienogest (E2V/DNG) in women with menstrually-related migraine (MRM)
No full textEffects of an estrogen-free, desogestrel-containing oralcontraceptive in women with migraine with aura: a prospective diary-based pilotstudy.
No full textSynthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging
No full textIn this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer
Evaluación geotécnica de los suelos del terreno de fundación para la construcción de la avenida costanera sur de la ciudad de Puno, Provincia de puno, Departamento de Puno
No full textEl presente proyecto de investigación, se encuentra ubicado en la Avenida Costanera Sur de la ciudad de Puno, cuyo propósito fue realizar una evaluación geotécnica para un proyecto de construcción vial mediante la determinación de sus características geotécnicas del terreno de fundación y canteras. La metodología aplicada en el estudio es de tipo descriptivo y analítico, realizados mediante la recopilación de datos y resultados de forma cualitativa y cuantitativa, para su posterior análisis e interpretación. El área de estudio comprende un trazo de 2+750km, en el cual se realizó 12 calicatas con profundidades de 1.40m a 3.60m, estableciendo su nivel freático de 1.30m a 2.50m. Se determinó que el terreno de fundación no es favorable, ya que encontramos limos de baja a alta plasticidad (MH), con capacidad de soporte CBR al 95% de MDS promedio de 5.2% la cual corresponde a la categoría de subrasante insuficientes (S1, CBR ≥3% a CBR <6%), y una expansividad superior al 100%. Frente a estos problemas de suelos inestables, se evaluó tres canteras para proponer su uso para el mejoramiento del terreno de fundación durante la construcción de la vía, llegándose a evaluar para el relleno pétreo la cantera San Luis de Alva, cantera que se caracteriza por presentar roca volcánica las cuales cumplen con las especificaciones exigidas en el desgaste de abrasión con un 27.13%; y para la conformación de la subbase y base, se mezclara dos canteras, cantera ligante Jayllihuaya en un 60% cuyo material es una grava arcillosa, y cantera Cutimbo en un 40% de grava de rio donde no presenta plasticidad, las cuales cumple con la especificación de la gradación A exigida por el manual de carreteras; garantizando de esta manera la estabilidad del terreno de fundación para la construcción de la Avenida Costanera Sur
Bonifica del suolo da metalli, semimetalli e idrocarburi policiclici aromatici : modello numerico per elettrocinesi
No full textLAUREA MAGISTRALEIl presente lavoro di tesi tratta della modellazione numerica del processo di EK per la bonifica di un terreno a media permeabilità. Il terreno preso in esame è soggetto alla contaminazione di fenantrene, piombo e arsenico. Scopo della modellazione, eseguita utilizzando il software COMSOL Multiphysics, è quello di simulare la mobilizzazione e il trasporto dei contaminanti in un terreno saturo sotto l’effetto dei meccanismi elettrocinetici con l’obiettivo di individuare le condizioni operative (potenziale elettrico agli elettrodi costante e/o corrente elettrica costante) che consentano di applicare efficacemente l’elettrocinesi per la bonifica di un terreno contaminato.This thesis work deals with the numerical modeling of the EK process for the remediation of a medium permeability soil polluted by phenanthrene, lead and arsenic. The purpose of the modeling, performed using the COMSOL Multiphysics software, is to simulate the pollutants mobilization and transport in a saturated soil sample under the effects of electrokinetic mechanisms in order to identify the operating conditions (constant electric potential at electrodes and/or constant electric current) that allow the effective application of electrokinesis for the remediation of contaminated soil
Management of hypoactive sexual desire disorder in women: current and emerging therapies
No full textRossella E Nappi1,2, Ellis Martini1,2, Erica Terreno1,2, Francesca , Albani2, Valentina Santamaria1,2, Silvia Tonani MD1,2, Luca Chiovato MD2, Franco Polatti MD11Research Center for Reproductive Medicine, Section of Obstetrics and Gynecology, Department of Morphological, Eidological and Clinical Sciences, 2Gynecological Endocrinology and Menopause Unit, Department of Internal Medicine and Endocrinology, IRCCS Maugeri Foundation; University of Pavia, ItalyAbstract: Hypoactive sexual desire disorder (HSDD) is a common multifactorial condition which is characterized by a decrease in sexual desire that causes marked personal distress and/or interpersonal difficulty. The general idea that HSDD is a sexual dysfunction difficult to treat is due to the large number of potential causes and contributing factors. Indeed, a balanced approach comprising both biological and psycho-relational factors is mandatory for accurate diagnosis and tailored management in clinical practice. There are currently no approved pharmacological treatments for premenopausal women with HSDD, while transdermal testosterone is approved in Europe for postmenopausal women who experience HSDD as a result of a bilateral oophorectomy. Even though the role of sex hormones in modulating the sexual response during the entire reproductive life span of women is crucial, a better understanding of the neurobiological basis of sexual desire supports the idea that selective psychoactive agents may be proposed as nonhormonal treatments to restore the balance between excitatory and inhibitory stimuli leading to a normal sexual response cycle. We conclude that the ideal clinical approach to HSDD remains to be established in term of efficacy and safety, and further research is needed to develop specific hormonal and nonhormonal pharmacotherapies for individualized care in women.Keywords: sexual desire, distress, testosterone, psychoactive drugs, psychosexual interventionsErratum for this paper has been publishe
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