278 research outputs found
Tom Wharton Alongside Turkish Agricultural Engineers Erdogan Bilgic and Mete Erguder Checking Capacity of Field Drainage Ditch
No full textPhotograph of Tom Wharton, WPS #1 Head with Turkish agricultural engineers Erdogan Bilgic and Mete Erguder checking capacity of field drainage ditch, which drains into Tony Hollow Creek. People shown in photo go as followed from left to right: 1. Erdogan Bilgic, 2. Mete Erguder, 3. Tom Wharton. The back of the photograph proclaims, "Checking capacity of field drainage ditch. This drains into Tony Hollow Creek (Line Creek near Verden, Oklahoma.) Left to right, Turkish agricultural engineers Erdogan Bilgic and Mete Erguder with Tom Wharton, Head, WPS #1.
WPS #1 Planning Engineer, Dellas Anderson, alongside Turkish Agricultural Engineers Mete Erguder and Erdogan Bilgic Checking Progress in Installing Floodwater Retarding Structures for Reduction of Floodwater Damage in Reach II of the Washita River
No full textPhotograph of WPS #1 Planning Engineer, Dellas Anderson, alongside Turkish Agricultural Engineers Mete Erguder and Erdogan Bilgic checking progress in installing floodwater retarding structures for reduction of floodwater damage in Reach II of the Washita River. People shown in photo go as followed from left to right: 1. Dellas Anderson, 2. Mete Erguder, 3. Fikret Gormen. The back of the photograph proclaims, "Dellas Anderson, Planning Engineer, WPS #1, Mete Erguder and Erdogan Bilgic (left to right) Agricultural Engineers from Turkey, check progress in installing floodwater retarding structures for reduction of floodwater damage in Reach II of the Washita River.
Framework for a web-based breast imaging learning module built on the open-source CAISIS platform and integrated with the new Breast Imaging EMR and existing breast imaging information technology infrastructure at Capital District Health Authority
No full textInternship report - Summer 2012This report describes the work performed during an 18-week summer internship in the
Department of Diagnostic Radiology at Capital District Health Authority (CDHA) by Master of
Health Informatics (MHI) candidate Mete Erdogan as part of the requirements for the MHI
program at Dalhousie University in Halifax, Nova Scotia). The internship project involved
designing and developing a framework for building a web-based breast imaging learning module that is integrated with the existing breast imaging IT infrastructure at CDHA and the new Breast Imaging EMR (BIEMR). BIEMR was built upon the open-source CAISIS data management system and is currently in the final stages of user acceptance testing.
Nova Scotia is the only province in Canada that has an organized breast screening program with full capture of all breast imaging taking place within the province in a single database. The Nova Scotia Breast Screening Program (NSBSP) was created as a provincial program in 1991 by the NS Department of Health & Wellness and given a mandate that includes monitoring the delivery of certain clinical services. Recently, the program completed a three-year process to upgrade the mammographic imaging equipment at every fixed site (screening and diagnostic) across the province from the traditional film-based mammography to Full-Field Digital Mammography (digital mammography or FFDM). The NSBSP is now in the process of updating their
information technology (IT) infrastructure to better manage their needs following this transition to FFDM technology. Working together, a group of radiologists, academic researchers, radiation technologists and breast screening program managers from Nova Scotia and Newfoundland have collaborated to develop a the BIEMR system, built upon the open-source CAISIS clinical and research database platform.
The goal of this internship project was to conceptualize a web-based breast imaging learning module that would provide radiologists, radiology residents, and radiation technologists with access to previous imaging cases for self-review and self-teaching purposes. Traditionally, radiology education and depended on teaching file repositories based on paper and film, making them prone to physical deterioration and limiting the ways in which the files could be created,stored, used and shared. Advances in digital imaging technologies such as the picture archive and communication system (PACS) environment and full-field digital mammography (FFDM) have opened the door to a new era of teaching in radiology. The development of a BIEMR Learning Module (BIEMR-LM) will provide an online educational resource and tool for radiologists, radiology residents, and mammography technologists to improve their ability to accurately read or acquire digital breast images and allow for radiologists and technologists to access and review
any previous imaging cases stored in the CAISIS database as part of a work-up review system.
The framework presented here proposes a number of open-source software solutions for the development of an online teaching file system for radiology. Going forward, it is recommended that the new BIEMR-LM be developed fully within the CAISIS platform using open-source tools.Department of Diagnostic Radiology, Capital District Health Authority, Halifax, N
Ronald Rogers Alongside Four Turkish Agricultural Engineers Studying Sedimentation Problems and Crop Production on Line Creek
No full textPhotograph of Ronald Rogers, WPS #1 alongside four Turkish agricultural engineers studying sedimentation problems and crop production on Line Creek. People shown in photo go as followed from left to right: 1. Erdogan Bilgic, 2. Ferit Ayla, 3. Mete Erguder, 4. Ronald Rogers, 5. Ilhan Varol. The back of the photograph proclaims, "Flood plain sedimentation and crop production are studied on Line Creek by group of specialist from Turkey. From left to right: Erdogan Bilgic, Ferit Ayla, Mete Erguder, Ronald Rogers, Ilhan Varol.
Crystal Structures of Cobalamin-Independent Methionine Synthase (MetE) from Streptococcus mutans: A Dynamic Zinc-Inversion Model
No full textCobalamin-independent methionine synthase (MetE) catalyzes the direct transfer of a methyl group from methyltetrahydrofolate to L-homocysteine to form methionine. Previous studies have shown that the MetE active site coordinates a zinc atom, which is thought to act as a Lewis acid and plays a role in the activation of thiol. Extended X-ray absorption fine structure studies and mutagenesis experiments identified the zinc-binding site in MetE from Escherichia coli. Further structural investigations of MetE from Thermotoga maritima lead to the proposition of two models: "induced fit" and "dynamic equilibrium", to account for the catalytic mechanisms of MetE. Here, we present crystal structures of oxidized and zinc-replete MetE from Streptococcus mutans at the physiological pH. The structures reveal that zinc is mobile in the active center and has the possibility to invert even in the absence of homocysteine. These structures provide evidence for the dynamic equilibrium model. (C) 2011 Elsevier Ltd. All rightshttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295496500012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Biochemistry & Molecular BiologySCI(E)PubMed7ARTICLE4688-69741
Biologic significance of Insulinoma-associated protein 1 (INSM1) expression in medullary thyroid carcinoma
No full text...Recep Tayyip Erdogan University Scientific Research Support FundRecep Tayyip Erdogan UniversityThis study has received financial support from Recep Tayyip Erdogan University Scientific Research Support Fund
An IBC and certificate based hybrid approach to WIMAX security
No full textWiMAX is a promising technology that provides high data throughput with low delays for various user types and modes of operation. These advantages make WiMAX applicable both for infrastructure purposes and end-client usage. Since WiMAX is presented as a network framework and a last-mile technology, it is believed to be capable of handling a wide range of usage scenarios. For example, while the end users have an opportunity to use WiMAX as the primary connection medium for acquiring services such as on-demand video streaming, VoIP connections and mobile bank transactions, the service providers may use it for data relaying purposes among access points. To meet the technical requirements of these various scenarios, majority of the WiMAX research has been conducted on physical and MAC layers; however little has been invested in a comprehensive and efficient security solution, which has resulted in a wide range of security weaknesses and reactive solutions. Many security problems remain to be addressed in different modes and for different user types even in the final security standard of WiMAX, PKMv2. In this thesis, we present a hybrid security solution combining Identity-Based Cryptography (IBC) and certificate based approaches to overcome the existing security problems of WiMAX without degrading service quality. IBC has potential benefits that can provide enhancements to the overall security and efficiency of the security standard. One such enhancement is combining user identity with the public key and therefore eliminating the public key distribution load from the network. However, IBC has a few caveats, such as the necessity of a secure medium to distribute private keys. To compensate for these disadvantages, in this study, IBC is combined with certificate-based security. As a result, the benefits of IBC are maintained while the disadvantages are eliminated. Using the hybrid approach, this study also aims to clarify the key revocation procedures and key lifetimes of WiMAX. To achieve this goal, key renewal intervals are examined and corresponding lifetimes are assigned to the credentials missing in both PKMv2 and PKMv1. Additionally, the key distribution procedures are investigated and a pattern is provided with the message exchange details. To be able to correctly assess the efficiency of this approach, a new mobility model is defined in the evaluation chapter of this thesis. Based on this model, the analysis has shown that our hybrid solution that combines IBC and the certified based security scheme results in a significant bandwidth improvement over the standard’s approach, PKMv2. This work is the first study that unites the advantages of both IBC and the certified-based security scheme for improved security while maintaining low overhead for WiMAX.M.S.Includes bibliographical referencesIncludes abstrac
Use of the Asian Clam (Corbicula fluminea Muller, 1774) as a Biomechanical Filter in Ornamental Fish Culture
No full textWOS: 000369639600009This study aimed to determine whether the Asian clam (Corbicula fluminea Muller, 1774) can be used as a biomechanical filter in ornamental fish aquariums. Various densities of this freshwater mussel were maintained with goldfish (Carassius auratus L., 1758), and their filtration efficiency, tolerance to environmental stressors, and viability were examined over 75 days along with the growth of both the mussels and fish. The addition of mussels removed large amounts of total suspended solids from the water, improved the quality of the water, and led to enhanced growth and feed conversion efficiency of the goldfish. Furthermore, the polyculture of fish and mussels in the aquariums did not have any negative effects on the viability of either species.University of Mugla Sitki Kocman Scientific Research Project Coordination UnitMugla Sitki Kocman University [2011/25]This research was supported by University of Mugla Sitki Kocman Scientific Research Project Coordination Unit (Project No: 2011/25)
R-Ras Proteins and TGF-Beta in Cancer
No full textThe development of cancer in humans is characterized by the accumulation of genetic alterations that either enhance or diminish activity in signaling pathways mediating cellular growth and proliferation. Over time these alterations gradually transform normal cells into malignant cells with aberrant properties. This process of transformation gives rise to cancerous cells no longer under control by natural growth-regulatory mechanisms within the body. The signaling pathways that govern cell growth and proliferation are mediated in part through the activity of regulatory GTPases, and the R-Ras family of GTPases has been implicated in the promotion of tumorigenesis.
Here we investigate the transforming properties of two highly homologous members of the R-Ras family. R-Ras and TC21(R-Ras2) are two Ras-related GTPases with the potential to induce oncogenic transformation in mammalian cells. Despite their similarities, these proteins have distinct functions and differ in their ability to transform cells in vitro and induce tumor
formation in vivo. We hypothesized that these differences in tumorigenicity resulted from differential activation of signaling pathways mediating growth and proliferation downstream of R-Ras and TC21. Using mammary epithelial cells we show that TC21 is significantly more transforming than R-Ras, and we demonstrate that distinct signaling events are required for these oncogenes to induce cellular transformation.
Transforming growth factor-beta (TGF-â) is a key regulator of cell growth in the body. TGF-â can cooperate with oncogenic members of the Ras superfamily to trigger cell transformation, yet it is unknown whether TGF-â exhibits this type of cooperative behavior with R-Ras and TC21. We investigated this possibility and found R-Ras-transformation to be highly dependent on TGF-â-signaling, while TC21-transformation was less dependent. Through these studies we have generated an in vitro/in vivo model of tumorigenesis that can be used to investigate the molecular events mediating R-Ras and TC21-induced transformation. Importantly, this model will be useful for identifying structural domains that mediate the oncogenic activity of R-Ras proteins, and for testing the efficacy of small molecule inhibitors as potential cancer therapeutics
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