131,623 research outputs found
Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity
No full text Pages R837–R847: K. A. Engelke, D. F. Doerr, and V. A. Convertino. “Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity.” On p. 837, the author line of the article and abstract and the affiliation line should read as follows: KEITH A. ENGELKE, DONALD F. DOERR, CRAIG G. CRANDALL, AND VICTOR A. CONVERTINO Department of Physiology, University of Florida, Gainesville, Florida 32610; National Aeronautics and Space Administration-Kennedy Space Center, Cape Canaveral, Florida 32899; Department of Physiology, University of North Texas Health Science Center, Ft. Worth, Texas 76107; and Physiology Research Branch, Clinical Science Division, Brooks Air Force Base, Texas 78235 </jats:p
Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity
No full text Pages R837–R847: K. A. Engelke, D. F. Doerr, and V. A. Convertino. “Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity.” On p. 837, the author line of the article and abstract and the affiliation line should read as follows: KEITH A. ENGELKE, DONALD F. DOERR,CRAIG G. CRANDALL, AND VICTOR A. CONVERTINO Department of Physiology, University of Florida, Gainesville, Florida 32610; National Aeronautics and Space Administration-Kennedy Space Center, Cape Canaveral, Florida 32899;Department of Physiology, University of North Texas Health Science Center, Ft. Worth, Texas 76107; and Physiology Research Branch, Clinical Science Division, Brooks Air Force Base, Texas 78235 </jats:p
IDENTIFICATION AND SEQUENCE-ANALYSIS OF THE RHIZOBIUM-MELILOTI DCTA GENE ENCODING THE C-4-DICARBOXYLATE CARRIER
No full textEngelke T, Jording D, Kapp D, Pühler A. IDENTIFICATION AND SEQUENCE-ANALYSIS OF THE RHIZOBIUM-MELILOTI DCTA GENE ENCODING THE C-4-DICARBOXYLATE CARRIER. JOURNAL OF BACTERIOLOGY. 1989;171(10):5551-5560
Genome-wide search for RNase P substrates reveals nuclear RNase P is involved in maturation of intronencoded box C/D small nucleolar RNAs
No full texthttp://deepblue.lib.umich.edu/bitstream/2027.42/85739/1/Coughlin-Engelke-2008.pd
Lipid-coated zinc oxide nanocrystals as innovative ROS-generators for photodynamic therapy
No full textPhotodynamic Therapy (PDT) is a medical treatment that combines the administration of a nontoxic drug, called photosensitizer (PS), with light irradiation of the targeted region. It has been proposed as a new cancer therapy, promising better selectivity and fewer side-effects compared to traditional chemo- and radio-therapies. PSs indeed can accumulate specifically within the region of interest so that when the light is directly focused only in that region the therapeutic effect is highly localized. Traditional PSs, like chlorins and porphyrins, suffer from several drawbacks such as aggregation in biological media and poor biocompatibility. Thus, the development of innovative photosensitizers able to overcome these issues is crucial to the therapeutic action of PDT. Among the others, nanostructured Zinc Oxide (ZnO) has been recently proposed as new therapeutic agent and PS thanks to its semiconducting properties, biocompatible features, and ease of functionalization [1]. Nevertheless, further efforts are needed in order to improve its colloidal stability in biological media and to unravel the effective therapeutic mechanism. Here, we propose the synthesis and characterization of lipid-coated ZnO nanoparticles as new photosensitizer for cancer PDT [2]. First, by Dynamic Light Scattering (DLS) experiments, we show that the lipid-coating increases the colloidal stability of the ZnO NPs in Phosphate buffered saline (PBS). Then, using Electron Paramagnetic Resonance (EPR) coupled with the spin-trapping technique, we demonstrate and characterize the ability of bare and lipid-coated ZnO NPs to generate Reactive Oxygen Species (ROS) in water only when remotely actuated via light irradiation. Interestingly, our results aware that the surface chemistry of the NPs greatly influence the type of photo-generated ROS. Finally, we show that our NPs are effectively internalized inside human epithelial carcinoma cells (HeLa) via a lysosomal pathway and that they are able to generate ROS inside cancer cells. [1] B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese and V. Cauda, J. Mater. Chem. B. under revision. [2] A. Ancona, H. Engelke, N. Garino, B. Dumontel, W.Fazzini and V. Cauda, to be submitted. The support from ERC Starting Grant - Project N. 678151 "Trojananohorse" is gratefully acknowledged
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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