180 research outputs found
Other title: Mindy McGinnis
No full text"Choose to Read Ohio."Author Mindy McGinnis with her book, "Not a drop to drink.
Exploring property driven design fabrication through materials testing and software development
No full textThesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis. Vita.Includes bibliographical references (p. 33).Since its introduction in the late 1980s, layered manufacturing has become an increasingly efficient and common means to delivering functional and visually representative prototypes in relatively short amounts of time from previously prepared Computer-Aided Design files. However, most layered manufacturing technologies today produce only single material, constant property prototypes from a limited array of materials. In this project, we explore a different approach to layer manufacturing, namely, a layered manufacturing product that, while using a single material, produces an entity of varying material properties. Materials testing of PMC®-724 demonstrate the material's capacity to possess a range of Shore A Hardness over a range of elasticity, illustrating the potential for printing with variable property materials. Moreover, we will also explore a new approach to fabrication that challenges the concept of Computer- Aided Manufacturing (CAM) by introducing a software application that, rather than providing a means of digitizing the geometry of a completed design, allows engineers and designers to create and design structures that are defined at various points by their material behavior as opposed to their geometry. As a proof of concept demonstration, a mono-material, variable property shoe sole will be printed using property-mapped polyurethane elastomer PMC®-724 with the new software.by Mindy Eng.S.B
Fabrication and evaluation of a tyrosine-derived polycarbonate conduit to enhance functional recovery of a 5 mm peripheral nerve gap in a mouse femoral nerve model
No full textEach year, over 200,000 people in the United States are treated for peripheral nerve injuries requiring surgery. Several nerve guidance conduits (NGCs) have been approved by the FDA, however, when used to repair critical size defects, regeneration results in limited functional recovery and poor quality. Therefore, a conduit fabricated from a material encouraging regeneration, specifically enhancing neurite outgrowth and functional recovery is required. Tyrosine-derived polycarbonates (TyrPCs) are biodegradable and biocompatible polymers offering a unique chemistry that allows for the optimization of their chemical, mechanical, and cellular properties for a specific application. These materials have been used in several medical devices and are effective at supporting neurite outgrowth in vitro. Additionally, peptide mimics of HNK-1 elucidated by the Schachner laboratory show significant promise when used in soluble form within conduits used to treat short defects. For critical size defects, soluble HNK-1 may not suffice; the mimic may diffuse away from the injury site. Thus, the goal of this research was twofold: 1) to develop a TyrPC NGC to treat critical size nerve defects and 2) to establish alternative methods of HNK-1 delivery. Three methods were explored: a collagen hydrogel filler grafted with HNK-1 (developed and provided by the Shreiber laboratory), the secretion of HNK-1 from genetically engineered stem cells, and slow release of HNK-1 from the NGC outer walls. TyrPC was compared to commercially available polyethylene in vitro and conduits fabricated from both materials were evaluated in the mouse femoral nerve model. In vitro results indicated greater protein adsorption and neurite outgrowth on TyrPC as compared to polyethylene. In vivo results showed improved functional recovery and quality of nerve regeneration in animals treated with TyrPC and suggested greater Schwann cell presence and fibrin matrix formation. Furthermore, in vitro results confirmed usefulness of 2 new methods for HNK-1 delivery, release from stem cells and the NGC itself. In vivo studies demonstrated that the influence of a collagen hydrogel with and without HNK-1 depends upon the TyrPC nerve conduit structure: whether or not the conduit was porous. In conclusion, conduits fabricated from TyrPC offer the potential for treatment of critical size nerve gaps.Ph. D.Includes bibliographical referencesIncludes vitaby Mindy Iris Ezr
Camp Spurs Young Authors
No full textMindy Legard Larson ’95 taps the creativity of elementary students during an Author Camp for young writers
Future Life-Cycle Footprints of Passenger Transportation in San Francisco
No full textabstract: Vehicle trips presently account for approximately 50% of San Francisco’s greenhouse gas emissions(San Francisco County Transportation Authority, 2008). City and county officials have developed aggressive strategies for the future of passenger transportation in the metropolitan area, and are determined to move away from a “business as usual” future. This project starts with current-state source data from a life-cycle comparison of urban transportation systems (Chester, Horvath, & Madanat, 2010), and carries the inventoried emissions and energy usage through by way of published future scenarios for San Francisco. From the extrapolated calculations of future emissions/energy, the implied mix of transportation modes can be backed out of the numbers. Five scenarios are evaluated, from “business as usual” through very ambitious “healthy environment” goals. The results show that when planners and policymakers craft specific goals or strategies for a location or government, those targets, even if met, are unlikely to result in the intended physical outcomes. City and state governments would be wise to support broad strategy goals (like 20% GHG reduction) with prioritized specifics that can inform real projects leading to the goals (for instance, add 5 miles of bike path per year through 2020, or remove 5 parking garages and replace them with transit depots). While these results should not be used as predictions or forecasts, they can inform the crafters of future transportation policy as an opportunity for improvement or a cautionary tale
Cognitive influences on the sensorimotor gating of the acoustic startle reflex
No full textPrepulse inhibition (PPI) is viewed as a measure of sensorimotor gating in which the startle response to a sudden intense stimulus (pulse) is attenuated by a weaker stimulus (prepulse) that immediately precedes the pulse. Similarly, in the cognitive domain, individuals can filter out unnecessary thoughts and impulses, essentially “cognitive gating.” There are many neuroanatomical overlaps between the sensorimotor gating and cognitive gating domains, as well as the coupling of deficiencies of both in certain mental disorders. Using a novel paradigm, the current study investigated whether changes in sensorimotor gating can be linked to cognitive gating. One hundred and two healthy volunteers were divided into groups and underwent two acoustic startle PPI sessions, before and after a specific task. Depending on the group, the task consisted of either a passive activity or one of three cognitive tasks, varying in cognitive gating demands. Passive activity between PPI sessions had differential effects on percent inhibition changes compared to an intervening cognitively demanding task. That is, cognitive gating tasks, but not attentional tasks, interfered with PPI magnitude, with systematic variations occurring between male and female subjects. Overall, the results imply a strong relationship between sensorimotor and cognitive gating domains, providing an opportunity to broaden our understanding of potential mechanisms underlying each of these processesM.S.Includes bibliographical referencesby Ruth Mindy Glas
Supplemental Tables - Top Authors in Dermatology: Comparisons of Standardized Database Citation Indicators
No full textSupplemental Tables - Top Authors in Dermatology: Comparisons of Standardized Database Citation Indicators.
Data derived from Baas, Jeroen; Boyack, Kevin; Ioannidis, John P.A. (2020), “Data for "Updated science-wide author databases of standardized citation indicators"”, Mendeley Data, V2, doi: 10.17632/btchxktzyw.2
Supplemental Table 1: Top 50 Dermatology Authors by 2019 Career-Long Metrics, Excluding Self-Citations.
Supplemental Table 2: Top 50 Dermatology Authors by 2019 Single-Year Metrics, Excluding Self-Citations.
Supplemental Table 3: Top 50 Dermatology Authors by 2019 Career-Long Metrics, All Citations Including Self-Citations.
Supplemental Table 4: Top 50 Dermatology Authors by 2019 Single-Year Metrics, All Citations Including Self-Citations
Birmingham News sleeve BN0059090
No full textShelby Foote / Author Shelby Foote will be touring the Hoover library . . . See Ginny or library director Linda Andrews . . . Want shot of Foote talking with library staffers or something along those lines / Municipal Drive at U.S. 31 across from city hall / Mindy Boudenheimer / Linda [--dre] / [Work order included
Nociceptive SSEPs induced using multisine frequency modulated pulse trains: An exploratory study in inducing multi-frequency SSEPs
No full textSteady state evoked potentials (SSEPs) using multiple frequency inputs are a well-known method to study the underlying dynamics in the visual, auditory and somatosensory system. Multi-frequency SSEPs provide insight into system dynamics such as delay, non-linearities, and frequency response function. Despite extensive research, little is known about the nociceptive system and its dynamics. Previous research showed the possibility to evoke single frequency nociceptive SSEPs using block wave stimulation. In the present study, we explored the feasibility of evoking multi-frequency nociceptive SSEPs using a multisine frequency modulated pulse train. The novel electrical stimulation technique using a frequency pulse train composed of 3, 7 and 13 Hz can stimulate multiple frequencies simultaneously. For the first time, we were able to induce multi-frequency SSEPs indicated by a contralateral maximal signal to noise ratio EEG response for 3 and 7 Hz. The power in 3 and 7 Hz showed significantly higher power compared to all other frequencies up until 40 Hz. The novel stimulation technique offers a unique opportunity to measure multi-frequency SSEPs related to nociceptive processing, allowing better localization of nociceptive signal processing and possible insight into the dynamics of the nociceptive regulation system
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