33 research outputs found
Retrospective from departing UM Provost Pardis Mahdavi
No full textThis week\u27s guest is Dr. Pardis Mahdavi, an Iranian-American professor, administrator, outgoing provost at the University of Montana, and the newly named president of the University of La Verne. Pardis is the author of multiple books and served in leadership roles in several prominent universities.
In this episode Justin asks Pardis about her path into academia, what changes to the University of Montana and higher ed more broadly she would like to see and her goals for the new role as president of the University of La Verne.https://scholarworks.umt.edu/anewangle_podcasts/1307/thumbnail.jp
Corrigendum: Confirmatory factor analysis and gender invariance of the Persian version of psychological control scale: association with internalizing and externalizing behavior problems (Frontiers in Psychology, (2023), 14, (1128264), 10.3389/fpsyg.2023.1128264)
No full textCopyright © 2024 Habibi Asgarabad, Salehi Yegaei, Mokhtari, Izalnoo and Trejos-Castillo. cc-byIn the published article, there was an error in the correspondence details. As well as Pardis Salehi Yegaei, Mojtaba Habibi Asgarabad should also be listed as a corresponding author. The complete correspondence details are shown below: *Correspondence: Pardis Salehi Yegaei Mojtaba Habibi Asgarabad The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated
Development of a deep-sea submersible chemiluminescent analyzer for sensing short-lived reactive chemicals
No full text© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Taenzer, L., Grabb, K., Kapit, J., Pardis, W., Wankel, S. D., & Hansel, C. M. Development of a deep-sea submersible chemiluminescent analyzer for sensing short-lived reactive chemicals. Sensors, 22(5), (2022): 1709, https://doi.org/10.3390/s22051709.Based on knowledge of their production pathways, and limited discrete observations, a variety of short-lived chemical species are inferred to play active roles in chemical cycling in the sea. In some cases, these species may exert a disproportionate impact on marine biogeochemical cycles, affecting the redox state of metal and carbon, and influencing the interaction between organisms and their environment. One such short-lived chemical is superoxide, a reactive oxygen species (ROS), which undergoes a wide range of environmentally important reactions. Yet, due to its fleeting existence which precludes traditional shipboard analyses, superoxide concentrations have never been characterized in the deep sea. To this end, we have developed a submersible oceanic chemiluminescent analyzer of reactive intermediate species (SOLARIS) to enable continuous measurements of superoxide at depth. Fluidic pumps on SOLARIS combine seawater for analysis with reagents in a spiral mixing cell, initiating a chemiluminescent reaction that is monitored by a photomultiplier tube. The superoxide in seawater is then related to the quantity of light produced. Initial field deployments of SOLARIS have revealed high-resolution trends in superoxide throughout the water column. SOLARIS presents the opportunity to constrain the distributions of superoxide, and any number of chemiluminescent species in previously unexplored environments.This research was funded by the NSF Oceanographic Technology and Interdisciplinary Coordination (OTIC) program grant number 1736332 and NSF Chemical Oceanography program grant number 1924236. Partial support was provided by the Link Foundation Ocean Engineering and Instrumentation Fellowship (L.T.)
Quantum cascade laser-based reflectance spectroscopy: a robust approach for the classification of plastic type
No full text© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Michel, A. P. M., Morrison, A. E., Colson, B. C., Pardis, W. A., Moya, X. A., Harb, C. C., & White, H. K. Quantum cascade laser-based reflectance spectroscopy: a robust approach for the classification of plastic type. Optics Express, 28(12), (2020): 17741-17756, doi:10.1364/OE.393231.The identification of plastic type is important for environmental applications ranging from recycling to understanding the fate of plastics in marine, atmospheric, and terrestrial environments. Infrared reflectance spectroscopy is a powerful approach for plastics identification, requiring only optical access to a sample. The use of visible and near-infrared wavelengths for plastics identification are limiting as dark colored plastics absorb at these wavelengths, producing no reflectance spectra. The use of mid-infrared wavelengths instead enables dark plastics to be identified. Here we demonstrate the capability to utilize a pulsed, widely-tunable (5.59 - 7.41 µm) mid-infrared quantum cascade laser, as the source for reflectance spectroscopy, for the rapid and robust identification of plastics. Through the application of linear discriminant analysis to the resulting spectral data set, we demonstrate that we can correctly classify five plastic types: polyethylene terephthalate (PET), high density polyethylene (HDPE), low density polyethylene (LDPE), polypropylene (PP), and polystyrene (PS), with a 97% accuracy rate.Richard Saltonstall Charitable Foundation; National Academies Keck Futures Initiative (NAKFI DBS13)
Author Correction: Acute and chronic hypoxia differentially predispose lungs for metastases
No full textAn amendment to this paper has been published and can be accessed via a link at the top of the paper.</p
Revitalization of the Bazaar neighborhood in Tehran
No full textThe word “bazaar” refers to an ancient Persian word “wazaar” meaning market. This word has been transferred and used in other countries such as Turkey, Arabic countries, India and even China during economic interactions and exchanges between Iran and these countries.
Bazaars are historic market places that provide trade services as well as other functions. Their historic buildings are renowned for their architectural aesthetics, and in old cities such as Tehran (Iran) they are considered the centerpiece of activities with architectural, cultural, historical, religious, and commercial values. However, during the past 400 years, they have undergone social and environmental changes. The neighborhood of the Tehran Bazaar has in recent decades become degraded, which has consequently decreased the social value of the historic Bazaar. The ruined urban condition makes it impossible for contemporary visitors to have a pleasurable experience while visiting the Bazaar, although that was historically their experience. As Tehran began to grow, much of the trade and finance in the city has moved to the newly developed section of the city, diminishing the importance of the bazaars. Today, shoppers and residents living in the Bazaar neighborhood inhabit dilapidated buildings, while customers and tourists—when they go there at all—experience a neighborhood that lacks even the most basic urban amenities such as sidewalks, drainage, benches, trees and lighting.
This design study required a number of investigations. It was essential to know whether there is appropriate access to the neighborhood in general and to the Bazaar specifically, and whether or not these access routes provide pedestrians a safe and healthy experience. Additionally, I looked at social context and sense of community, commercial viability, traffic, and urban hygiene. I interviewed many of the shop owners, customers, and residents in the neighborhood in order to learn their needs.
This thesis addresses the issues that threaten the values of the Bazaar. These issues can be seen in unaesthetic looks in both building scale and urban scale. It analyzes the existing conditions, cultural and historic context and develops a plan to resolve the threats. The proposed program introduces methods for developing a workable contemporary layer that responds to the needs of the neighborhood. This response proposes standards such as compatibility with the historic fabric. It also addresses how to create green spaces and resolve traffic issues with minimum intervention, while preserving the old and historic character. With this theory, the bazaar neighborhood hopefully will perform again as a meaningful residential, commercial, social, and religious hub in Tehran, creating a tight vibrant urban fabric.Item withdrawn by Laura Spradlin ([email protected]) on 2014-07-22T13:08:13Z
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Acute and chronic hypoxia differentially predispose lungs for metastases
No full textOscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of the differential expression of the two primary hypoxia inducible transcription factor isoforms, HIF-1α and HIF-2α, and pulmonary hypoxia to investigate how the hypoxia response of the vascular endothelium remodels the lung pre-metastatic niche. Molecular responses to acute versus chronic tissue hypoxia have been proposed to involve dynamic HIF stabilization, but the downstream consequences and the extent to which differential lengths of exposure to hypoxia can affect HIF-isoform activation and secondary organ pre-disposition for metastasis is unknown. We used primary pulmonary endothelial cells and mouse models with pulmonary endothelium-specific deletion of HIF-1α or HIF-2α, to characterise their roles in vascular integrity, inflammation and metastatic take after acute and chronic hypoxia. We found that acute hypoxic response results in increased lung metastatic tumours, caused by HIF-1α-dependent endothelial cell death and increased microvascular permeability, in turn facilitating extravasation. This is potentiated by the recruitment and retention of specific myeloid cells that further support a pro-metastatic environment. We also found that chronic hypoxia delays tumour growth to levels similar to those seen in normoxia, and in a HIF-2α-specific fashion, correlating with increased endothelial cell viability and vascular integrity. Deletion of endothelial HIF-2α rendered the lung environment more vulnerable to tumour cell seeding and growth. These results demonstrate that the nature of the hypoxic challenge strongly influences the nature of the endothelial cell response, and affects critical parameters of the pulmonary microenvironment, significantly impacting metastatic burden. Additionally, this work establishes endothelial cells as important players in lung remodelling and metastatic progression.</p
The liminar status of begaguien novel’s principal personage Béni ou le pardis privé Dr Zoulikha NASRI
No full textLe travail que nous menons ici autour de la question de la liminalité a pour originela lecture de Béni ou le paradis privé (1989) d’Azouz Begag. Appliqué comme outil d’analysedu personnage, ce concept issu de la réflexion de Van Gennep ([1981 1909]) sur les rites depassage permettra de comprendre à travers le texte de l’auteur franco-algérien la situationdans laquelle se retrouvent les « enfants de la postcolonie ».The reflexion conducted here about the liminality notion hasfor origin thebegaguien novel’s, Béni ou le paradis privé (1989). Applicated as read grid, this concept of VanGennep ([1981] 1909) exploited in anthropology’s domain, precisely around passage rites, willhelp us to understand trought author French-algerian’s text the no easy situation of thepostcolonie’s children
Hypoxia and HIF- activation in endothelial cells affect metastatic pre-disposition in a time- and isoform-specific manner
No full textThe metastatic cascade is initiated at the primary tumor, but the compliance of the tumor-free distant organs in their own metastatic colonization is mostly understudied. Metastases occur primarily through hematogenous dissemination, involving multiple steps where the tumor cells need to exploit or manipulate the endothelial barrier. Unlike that in the primary tumour microenvironment, the vasculature at the distant (pre)metastatic site is presumably intact. A healthy microvascular network restricts extravasation, a limiting step for metastatic seeding; and a secondary angiogenic switch is necessary for secondary tumour proliferation. Both events- extravasation and secondary proliferation - require that the vasculature’s compliance with tumor cells. We know from our and others’ studies that endothelial cell (EC) behavior and physiology are intrinsically connected to the activation of hypoxia inducible transcription factors (HIF), and that deletion of these isoforms in EC have major effects in metastatic take. HIF activation in EC affects their proliferation, survival, monolayer permeability and intercellular communication, and occurs in response to organ status or systemic signals. Here, we investigated the role of activation EC-specific HIF- isoforms by manipulating their stabilization short and prolonged hypoxia exposure, and showed that (1) EC HIF-1 in the lung is transiently activated during acute hypoxia, where it (2) creates a pro-metastatic microenvironment, resulting in (3) disruption of the endothelial barrier and recruitment of pro-metastatic macrophages. Stabilization of HIF-2 was seen highest after prolonged hypoxia, and had a protective effect on microvascular integrity and metastasis. These results were validated using lung EC-specific deletion of either HIF-1 or HIF-2.<br/
