122 research outputs found
Prevalence and impact of COVID-19 sequelae on treatment pathways and survival of patients with cancer who recovered from SARS-Cov-2 infection: results from the OnCovid registry.
No full textretrospective, registry study David J Pinato, Josep Tabernero, Mark Bower, Lorenza Scotti, Meera Patel, Emeline Colomba, Saoirse Dolly, Angela Loizidou, John Chester, Uma Mukherjee, Alberto Zambelli, Alessia Dalla Pria, Juan Aguilar-Company, Diego Ottaviani, Amani Chowdhury, Eve Merry, Ramon Salazar, Alexia Bertuzzi, Joan Brunet, Matteo Lambertini, Marco Tagliamento, Anna Pous, Ailsa Sita-Lumsden, Krishnie Srikandarajah, Johann Colomba, Fanny Pommeret, Elia Segui, Daniele Generali, Salvatore Grisanti, Paolo Pedrazzoli, Gianpiero Rizzo, Michela Libertini, Charlotte Moss, Joanne S Evans, Beth Russell, Nadia Harbeck, Bruno Vincenzi, Federica Biello, Rossella Bertulli, Raquel Lilian, Sabrina Rossi, Maria Carmen Carmona-Garcia, Carlo Tondini, Laura Fox, Alice Baggi, Vittoria Fotia, Alessandro Parisi, Giampero Porzio, Maristella Saponara, Claudia Andrea Cruz, David Garcia-Illescas, Eudald Felip, Ariadna Roque Lloveras, Rachel Sharkey, Elisa Roldan, Roxana Reyes, Irina Earnshaw, Daniela Ferrante, Javier Marco-Hernandez, Isabel Ruiz-Camps, Gianluca Gaidano, Andrea Patriarca, Riccardo Bruna, Anna Sureda, Clara Martinez-Vila, Ana Sanchez de Torre, Luca Cantini, Marco Filetti, Lorenza Rimassa, Lorenzo Chiudinelli, Michela Franchi, Marco Krengli, Armando Santoro, Aleix Prat, Mieke Van Hemelrijck, Nikolaos Diamantis, Thomas Newsom-Davis, Alessandra Gennari, Alessio Cortellini, on behalf of the OnCovid study group
PARADOKSALITAS PEMOSISIAN PEREMPUAN NOVEL COLOMBA KARYA PROSPER MERIMEE
No full textWomen have been narrated by men authors since classical literature; this has continued into contemporary
literature. In the 19th century, many authors were interested in narrating and positioning women in
their novels. This period can be considered one of transition, in which traditionality and modernity were
contested because of influences from the industrial revolution and many other social movements in
Europe. This period was also one of challenge, with the appearance of Gustave Flaubert’s novel Madame
Bovary, which was questioned because of moralistic issues. If in the early 19th century traditionality
was represented by Eugénie Grandet and Balzac’s figures of woman, but in the middle of the century
Flaubert dealt with freedom of sexuality, what discourses were presented in between these two different
periods? This article aims at explaining the bridging of the gap between the symbols of traditionality
and modernity, especially through the representation of women. Mérimée’s novel, Colomba, depicts the
agency of a woman named Colomba. In this novel, Mérimée not only showed the position of women vis
à vis men in parental or conjugal relation, like in the novels Eugénie Grandet or Madame Bovary. Rather,
the author attempted to look at the relationship between masculinities and femininities in a Corsican
context, in which the intersection of gender and social class (as well as traditions) was different than in
the Parisian context. The relation between the novel and the social structure in the 19th century Europe
plays an important part in the discussion and explanation of the relationship between the literature and
social narration of that perio
Addition of Primary Metastatic Site on Bone, Brain, and Liver to IMDC Criteria in Patients With Metastatic Renal Cell Carcinoma: A Validation Study
No full textInternational Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria are a key element by which the choice of systemic treatment is decided. However, heterogeneity may exist among IMDC risk categories. The first site of metastatic disease occurrence is related to overall survival. The addition of this variable to the others within the recognized IMDC score improves prognosis prediction.Background: The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria have been largely adopted in clinical practice. In a recent retrospective study, we assessed that the addition of the first site of metastatic disease to brain, bone, and liver improves prognostic stratification of patients with metastatic renal cell carcinoma (mRCC). Here, we performed an external validation in patients with mRCC. Our aim was to evaluate if the addition of a new independent variable could improve IMDC prognosis prediction and reduce heterogeneity within risk categories. Patients and Methods: We selected all 1073 patients treated at a single institution for mRCC and included in the Institute Gustave Roussy Renal Cell Carcinoma database. All patients included received at least 1 line of targeted therapy or immune checkpoint inhibitors. Univariate and multivariate analyses (Cox regression model) were performed. Bootstrap validation of the final model was also carried out for internal validation. The IMDC modified classification was defined by the addition of the seventh variable, and we defined the modified IMDC good-risk criteria as 0 risks, intermediate-risk as 1 to 2 risks, and poor-risk as 3 or more risks. Results: The presence of brain, bone, and/or liver as the first site of metastatic disease plus the other variables included in the IMDC score were statistically significant variables associated with overall survival (OS) after univariate and multivariate analysis and bootstrap validation. Finally, 122 (15%) patients had a modification of their initial risk category. The median OS in the poor-, intermediate-, and favorable-risk groups was 10, 26, and 52 months, respectively (P < .001). The bias-corrected concordance index in patients receiving immune checkpoint inhibitors (n = 241) was 0.71. Conclusion: The addition of brain, bone, and/or liver metastases as an additional variable to the other IMDC variables improves the prognostic predictive power of the model
Antiproteinuric effect of add-on paricalcitol in Fabry disease patients: a prospective observational study.
No full textBACKGROUND:
Proteinuria is the predominant risk factor for renal disease progression in Fabry disease (FD). When urine protein excretion is controlled to 0.50 g/24 h persisting despite ERT and anti-RAS therapy titrated to maximum tolerated dosage.
METHODS:
Fifteen FD patients were selected and studied in the first 6 months of add-on oral PCT (1 μg/day) and, in order to verify the dependence of proteinuria reduction on PCT, 3 months after drug withdrawal.
RESULTS:
At baseline, proteinuria was 1.3 ± 0.6 g/24 h. Six months of add-on PCT significantly decreased proteinuria to 0.4 ± 0.3 g/24 h, with levels <0.50 g/24 h achieved in four patients at Month 1, six at Month 3, and in 12 by Month 6, in the absence of changes to BP and GFR. Proteinuria recovered to basal value after drug withdrawal.
CONCLUSIONS:
In conclusion, our study is the first evidence that PCT is effective in reducing proteinuria in FD patients in the presence of ERT and anti-RAS therapy.
© The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved
sj-docx-1-tam-10.1177_17588359211053416 – Supplemental material for COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359211053416 for COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry by Laia Garrigós, Cristina Saura, Clara Martinez-Vila, Alberto Zambelli, Mark Bower, Barbara Pistilli, Matteo Lambertini, Diego Ottaviani, Nikolaos Diamantis, Ailsa Lumsden, Sonia Pernas, Daniele Generali, Elia Seguí, Gemma Viñas, Eudald Felip, Ana Sanchez, Gianpiero Rizzo, Armando Santoro, Alessio Cortellini, Ylenia Perone, John Chester, Maria Iglesias, Marta Betti, Bruno Vincenzi, Michela Libertini, Francesca Mazzoni, Federica Zoratto, Rossana Berardi, Annalisa Guida, Rachel Wuerstlein, Angela Loizidou, Rachel Sharkey, Juan Aguilar Company, Marta Matas, Chiara Saggia, Lorenzo Chiudinelli, Emeline Colomba-Blameble, Myria Galazi, Uma Mukherjee, Mieke Van Hemelrijck, Mar Marin, Carla Strina, Aleix Prat, Helena Pla, Eva Maria Ciruelos, Alexia Bertuzzi, Lucia del Mastro, Giampiero Porzio, Thomas Newsom-Davis, Isabel Ruiz, Maria Belen Delany, Marco Krengli, Vittoria Fotia, Alessandro Viansone, Neha Chopra, Margarita Romeo, Ramon Salazar, Ignacio Perez, Francesca d’Avanzo, Michela Franchi, Manuela Milani, Fanny Pommeret, Marco Tucci, Paolo Pedrazzoli, Nadia Harbeck, Daniela Ferrante, David J. Pinato and Alessandra Gennari in Therapeutic Advances in Medical Oncology</p
Weak solutions of a conservation law with memory
No full textIn this paper, the author obtains the existence and uniqueness of weak solutions of the Cauchy problem for a quasilinear equation of conservation type with memory ut +f(u)x +a∗ψ(u) = 0, u(0,x) = u0(x), in one space variable. The main additional hypothesesareψ(0)=0,ψ′ >0and(−1)na(n) ≥0forn=0,1,2
Diversities and Disparities in Endometrial Carcinoma (EC): Clinicopathological Features and Outcomes from Indigenous Populations, a French Multicentric Retrospective Study
No full textBackground: Disparities in access to cancer care remain a significant issue. Cancer epidemiology in the French overseas territories differs significantly from mainland (FRANCIM 2019 data). Indigenous populations are underrepresented in clinical trials, and little is known about their profiles and outcomes. This study reports on the clinicopathological features of EC patients from Martinique, Guadeloupe (French west Indies), French Polynesia (FP), Wallis and Futuna (WF) and Reunion Island. Methods: We conducted a multicentric retrospective study of EC patients treated in the aforementioned mentioned territories. Results: We included 1040 patients. Three distinct groups emerged from our analysis, each corresponding to specific geographical area. Patients from the South Pacific islands (FP and WF) were younger and predominantly obese compared to those in mainland France. The most common histological subtype was endometrioid, usually diagnosed at an early stage. In contrast, nearly 45% of patients from the FWI presented had non-endometrioid subtypes and were diagnosed at more advanced stages. Patients from Reunion showed clinical characteristics similar to those of Caucasian patients in mainland France (Table 1). Conclusion: The French overseas territories face unique challenges in the management of endometrial cancer. Progression-free survival rates are significantly lower compared to mainland France. These populations are underrepresented in research, and mainland guidelines are often extrapolated to them, despite their specific characteristics. Studying these populations more closely would allow for tailored treatment strategies and help reduce ethnic disparities.Contexte : Les disparités d'accès aux soins contre le cancer demeurent un problème majeur. L'épidémiologie des cancers dans les territoires français d'outre-mer diffère de celle de la France hexagonale (FRANCIM 2019). Les populations autochtones sont sous-représentées dans les essais cliniques, et leurs profils clinico-pathologiques sont peu connus. Cette étude analyse les caractéristiques clinicopathologiques des patientes atteintes de cancer de l'endomètre en Martinique, Guadeloupe (Antilles françaises), Polynésie française (PF), Wallis-et-Futuna (WF) et La Réunion. Méthodes : Nous avons mené une étude rétrospective multicentrique dans les territoires cités. Résultats : 1040 patientes, ont été incluses. Les patientes des îles du Pacifique Sud (PF et WF) étaient plus jeunes et principalement obèses. Le sous-type histologique dominant était l’endométrioïde, généralement diagnostiqué à un stade précoce. En revanche, près de 45 % des patientes des Antilles présentaient des sous-types non endométrioïdes à des stades plus avancés. Les caractéristiques des patientes de La Réunion étaient similaires à celles des patientes caucasiennes de France hexagonale. Conclusion : Les territoires d'outre-mer font face à des défis uniques pour la prise en charge du cancer de l'endomètre, avec des taux de survie sans progression inférieurs à ceux de France hexagonale. Ces populations, sous-représentées dans la recherche, nécessitent des stratégies de traitement adaptées pour réduire les disparités ethniques
Giovanni Sabadino degli Arienti y la obra Pudica Isabella
No full textEl manuscrito de la obra de Giovanni Sabadino degli Arienti Pudica Isabel se conserva inédito en la Sächsische Landesbibliothek de Dresde. De esta obra el autor realizó dos redacciones. Una, Trattato de Pudicizia, es posterior a 1484, año en que murió su esposa Francesca Bruni, y la dedicó a su cuñada, Colomba Bruni. Años más tarde, escribió otra versión, que dedicó a Isabel la Católica, bajo el título de Pudica Isabel, como el mismo autor declara. Nuestro artículo plantea unas cuestiones sobre la naturaleza de esta obra y las fuentes clásicas de los exempla que usó el autor.-- The manuscript of Giovanni Sabadino degli Arienti Pudica Isabel is kept unpublished in the Sächsische Landesbibliothek in Dresde. The author made two redactions of this work. One Trattato de Pudicizia after 1484, the year his wife Francesca Bruni died, which he dedicated to his sister-in-law, Colomba Bruni. Years later he wrote another version, which he dedicated to Isabella of Castile, under the title of Pudica Isabel, as the author himself declares. Our article raises some questions about the nature of this work and the classical sources of the exempla used by the author
Giovanni Sabadino Degli Arienti and the Work Pudica Isabel
No full textThe manuscript of Giovanni Sabadino degli Arienti Pudica Isabel is kept unpublished in the Sächsische Landesbibliothek in Dresde. The author made two redactions of this work. One Trattato de Pudicizia after 1484, the year his wife Francesca Bruni died, which he dedicated to his sister-in-law, Colomba Bruni. Years later he wrote another version, which he dedicated to Isabella of Castile, under the title of Pudica Isabel, as the author himself declares. Our article raises some questions about the nature of this work and the classical sources of the exempla used by the author.El manuscrito de la obra de Giovanni Sabadino degli Arienti Pudica Isabel se conserva inédito en la Sächsische Landesbibliothek de Dresde. De esta obra el autor realizó dos redacciones. Una, Trattato de Pudicizia, es posterior a 1484, año en que murió su esposa Francesca Bruni, y la dedicó a su cuñada, Colomba Bruni. Años más tarde, escribió otra versión, que dedicó a Isabel la Católica, bajo el título de Pudica Isabel, como el mismo autor declara. Nuestro artículo plantea unas cuestiones sobre la naturaleza de esta obra y las fuentes clásicas de los exempla que usó el autor
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