3,617 research outputs found
General Introduction
No full textHyaline cartilage enables us to move our joints even when exposed to high mechanical forces. Other types of cartilage can be found in tissues like the ear, nose, airway etc. In contrast to many other tissues only one type of cell is found in hyaline cartilage this cell is the chondrocyte. Since chondrocytes are capable to produce their own matrix, it is possible to generate cartilage in a laboratory setting. This approach applies to the ideas of tissue engineering. However aspects such as tissue architecture, integration to host tissue, and costs remain of concern when trying to repair and/or produce adequate hyaline cartilage capable to withstand high repetitive mechanical forces
Targeting Inflammatory Processes for Optimization of Cartilage Homeostasis and Repair Techniques
No full textThe outcome of cartilage repair techniques is often hampered by unwanted ossification (e.g. Intralesional osteophytes) at the site of the repaired cartilage. Furthermore, stimulating progenitor cells towards chondrocytes and locking them in their desired state is another important hinge point in cartilage repair techniques. Studying the cartilage formation process by endochondral ossification may provide important clues which further enhance cartilage repair techniques in general and may provide crucial information to prevent unwanted ossification in particular. During endochondral ossification mesenchymal progenitors differentiate into proliferative chondrocytes which gradually further differentiate into hypertrophic chondrocytes and finally die by apoptosis; the remaining scaffold is mineralised towards bone. This process takes place in growth plates, during fracture healing and in part during development of articular cartilage, where the endochondral ossification halts at the chondrogenic phase. While inflammation is generally regarded as a negative factor for joint homeostasis and cartilage development, it is also known that inflammation is the first and essential phase of tissue repair in general and bone fracture healing via endochondral ossifcation indeed also depends on haematoma formation and subsequent inflammatory microenvironment. Recently, a growing body of experimental evidence has been published, showing that inflammatory molecules (e.g. Nf-?b, cox-2, inos, tnfa, interleukins) and their down-stream pathways are not only associated with cartilage degeneration, but are also crucially involved in the initiation of the chondrogenic differentiation process and regulation of cartilage hypertrophy and mineralization. The data described in these reports suggest that one could use these inflammatory pathways for cartilage regenerative medicine, as the initiation of chondrogenic differentiation is a crucial moment for progenitor cell-based cartilage repair techniques. Furthermore, targeting inflammatory mediators may also provide a potential pharmacological approach to prevent or decrease chondrocyte hypertrophic differentiation and subsequent bone formation (e.g. Intralesional osteophytes) in cartilage repair techniques.this chapter describes important characteristics of hyaline articular cartilage, drawbacks of current cartilage repair techniques, the process of endochondral ossification and how inflammation related molecules are involved in different phases of endochondral ossification. In addition, this chapter discusses how better insight into these pathways may provide novel molecular tools to modulate chondrogenesis in cartilage regenerative medicine
sj-docx-1-car-10.1177_19476035221126343 – Supplemental material for Minced Autologous Chondral Fragments with Fibrin Glue as a Simple Promising One-Step Cartilage Repair Procedure: A Clinical and MRI Study at 12-Month Follow-Up
No full textSupplemental material, sj-docx-1-car-10.1177_19476035221126343 for Minced Autologous Chondral Fragments with Fibrin Glue as a Simple Promising One-Step Cartilage Repair Procedure: A Clinical and MRI Study at 12-Month Follow-Up by M.H.H. Wodzig, M.J.M. Peters, K.S. Emanuel, P.P.W. Van Hugten, W. Wijnen, L.M. Jutten, T.A. Boymans, D.V. Loeffen and P.J. Emans in CARTILAGE</p
sj-docx-2-sav-10.1177_19476035221126343 – Minced Autologous Chondral Fragments with Fibrin Glue as a Simple Promising One-Step Cartilage Repair Procedure: A Clinical and MRI Study at 12-Month Follow-Up
No full textsj-docx-2-sav-10.1177_19476035221126343 for Minced Autologous Chondral Fragments with Fibrin Glue as a Simple Promising One-Step Cartilage Repair Procedure: A Clinical and MRI Study at 12-Month Follow-Up by M.H.H. Wodzig, M.J.M. Peters, K.S. Emanuel, P.P.W. Van Hugten, W. Wijnen, L.M. Jutten, T.A. Boymans, D.V. Loeffen and P.J. Emans in CARTILAGE</p
sj-docx-1-car-10.1177_19476035211060506 – Supplemental material for 7-Tesla MRI Evaluation of the Knee, 25 Years after Cartilage Repair Surgery: The Influence of Intralesional Osteophytes on Biochemical Quality of Cartilage
No full textSupplemental material, sj-docx-1-car-10.1177_19476035211060506 for 7-Tesla MRI Evaluation of the Knee, 25 Years after Cartilage Repair Surgery: The Influence of Intralesional Osteophytes on Biochemical Quality of Cartilage by M.P.F. Janssen, M.J.M. Peters, E.G.M. Steijvers-Peeters, P. Szomolanyi, E.M.C. Jutten, L.W. van Rhijn, L. Peterson, A. Lindahl, S. Trattnig and P.J. Emans in CARTILAGE</p
sj-docx-2-car-10.1177_19476035211060506 – Supplemental material for 7-Tesla MRI Evaluation of the Knee, 25 Years after Cartilage Repair Surgery: The Influence of Intralesional Osteophytes on Biochemical Quality of Cartilage
No full textSupplemental material, sj-docx-2-car-10.1177_19476035211060506 for 7-Tesla MRI Evaluation of the Knee, 25 Years after Cartilage Repair Surgery: The Influence of Intralesional Osteophytes on Biochemical Quality of Cartilage by M.P.F. Janssen, M.J.M. Peters, E.G.M. Steijvers-Peeters, P. Szomolanyi, E.M.C. Jutten, L.W. van Rhijn, L. Peterson, A. Lindahl, S. Trattnig and P.J. Emans in CARTILAGE</p
Past veterinarians in South Africa
No full textAn alphabetical list containing short biographies of all deceased South African veterinarians up to 1990.[compiled by] P.J. (Bill) PosthumusVolume 1: AL -- Volume 2: M-ZAlso available in print http://137.215.9.20/record=b1893606ab2013ab201
Open brief aan den WelEdel. Gestr. Heer P.J. Joubert
No full textleyds-70-7201.pdf created from original pamphlet in the WJ Leyds Collection held in the Africana Section of the Stellenbosch University Library and Information Service.Dutch open letter to P.J. Joubert concerning a railroad concession granted to the author and two of his friends in 1885
Design, Modeling and Simulation of a 52MHz MEMS Gyroscope Device in 1.5um SOI
No full textIn this thesis , a simulation model of a MEMS gyroscope is presented. The model enables mode matching and analysis of the dynamic behavior of a gyroscope. Furthermore, the model allows the optimization the design parameters of the gyroscope. The simulated gyroscope operates at a frequency of 52MHz with amplitudes of 10nm and quality factor of 50,000. Finally, the drive mode measurements are presented at different bias voltages.Microelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc
Het gemeentelijk Investeringsraadsel: Het verband tussen gemeentelijke investeringen en lokale welvaartsontwikkeling
No full textDit proefschrift gaat over de vraag in hoeverre in Nederland de lokale welvaartsontwikkeling wordt bepaald door de gemeentelijke investeringsinspanning. Op project niveau is meestal wel het een en ander bekend over de maatschappelijke effecten, maar over de impact van de totale investeringsinspanning ontbreekt zowel fundamentele als toepasbare kennis. Het is een raadsel dat nog opgelost dient te worden. De doelstelling van dit proefschrift is daaraan een bijdrage te leveren.Housing System
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