28 research outputs found
Methodenentwicklung für die groß angelegte Vorhersage und Modellierung von Protein-Protein-Wechselwirkungen
No full textProtein-Protein-Interaktionen (PPIs), die für zahlreiche biologische Prozesse entscheidend sind, stellen die Biowissenschaften vor große Herausforderungen. Meine Dissertation befasste sich mit der Vorhersage und dreidimensionalen Modellierung von PPIs auf Proteomebene in vier verschiedenen Projekten. Zunächst haben wir experimentelle und rechnerische Methoden zur Charakterisierung von PPIs im Hochdurchsatzverfahren untersucht. Zweitens befassten wir uns mit den Herausforderungen des evolutionären Kopplungsansatzes EVcomplex, indem wir seine Überschaubarkeit um das Fünffache auf das Proteom von Escherichia coli (E. coli) und auf eukaryotische Interaktionen erweiterten. Darüber hinaus haben wir eine neuartige Pipeline für die automatisierte Strukturanalyse von groß angelegten Vernetzungsdaten entwickelt und sie zur Erforschung des menschlichen endolysosomalen Kompartiments eingesetzt. Schließlich haben wir ein neuartiges Framework, XLEC, entwickelt, das spärliche Daten aus Quervernetzungen (XL) und evolutionärer Kopplung (EC) für eine effiziente Charakterisierung von PPIs integriert. Diese Forschungsarbeit löst erfolgreich die Herausforderungen bei der Charakterisierung von PPIs und bietet neue Einblicke in die komplizierte Landschaft der Proteininteraktionen
Interference Mitigation in MIMO Systems with Imperfect CSI using Beamforming based Precoding Algorithm
No full textEffect of Educational Intervention on Pediatric Diabetes self Care Practices
No full textAbstract: Background: Diabetes mellitus is among the most common chronic illnesses in childhood, it is a chronic metabolic condition affecting the child’s physical and physiological growth and development. Aim of the study: Study the effect of educational intervention on pediatric diabetes self care practices. Research design: A quasi experimental design (one group pre/post test) was used in the study. Settings: The present study was carried out at pediatric outpatient unit affiliated to Suez Canal University Hospitals and Health Insurance Hospital at Ismailia city. Sample: A non probability purposive sample (30) of diabetic children at the previously mentioned settings. Tools for data collection: The data were collected using two tools namely structured interview questionnaire and observational checklists to assess diabetes self care practices. Results: There was statistically significant difference in the total mean scores of satisfactory knowledge and self care practice pre/immediate post educational intervention. The total satisfactory knowledge was 100% immediate post educational intervention compared with 6.7% pre intervention. The total satisfactory level of self care practice was 100% immediate post educational intervention compared with 63.3% pre educational intervention. Conclusion: The educational intervention had a positive effect on children's diabetes self care practices. Recommendations: Periodic educational interventions are required to achieve positive change on diabetic children's self care practices.
Keywords: Diabetic children, educational intervention, Knowledge, Nursing, Practice.
Title: Effect of Educational Intervention on Pediatric Diabetes self Care Practices
Author: Hadeer Hussien Soliman, Wafaa El- Sayed Ouda, Manal Farouk Mohamed, Rehab Hassan Kafl
International Journal of Novel Research in Healthcare and Nursing
ISSN 2394-7330
Vol. 9, Issue 3, September 2022 - December 2022
Page No: 55-64
Novelty Journals
Website: www.noveltyjournals.com
Published Date: 27-September-2022
DOI: https://doi.org/10.5281/zenodo.7115915
Paper Download Link (Source)
https://www.noveltyjournals.com/upload/paper/Effect%20of%20Educational%20Intervention-27092022-1.pdfInternational Journal of Novel Research in Healthcare and Nursing, ISSN 2394-7330, Novelty Journals, Website: www.noveltyjournals.co
Pharmacological Studies on Tildipirosin in Calves
No full textBovine respiratory disease (BRD) is the primary health problem in the beef cattle industry worldwide. Tildipirosin was injected as a metaphylaxis to healthy animals and also as a therapeutic to the clinically diseased animal at a dose of 4 mg/kg B.W. TD is effective in reducing the mortality rate and increasing the recovery rate from P. multocida infection which induces damage to the bronchioles and alveoli with fibrinopurulent bronchopneumonia represented by dilated bronchiole with caseated material in its lumen associated with severe leukocytic cells infiltration in the wall, multifocal areas of necrosis organized exudate infiltrated with many neutrophils in alveoli. PCR is considered the test of choice in the diagnosis of Pasteurella as it can identify organisms at any level regardless of tiny quantities of bacteria’s genome, consequently, the sensitivity and specificity of the test increased. Tildipirosin injection caused no significant changes in RBC count after treatment for the treated healthy and treated diseased group compared with the control group. Tildipirosin showed no significant changes in hemoglobin content and HCT of the treated healthy group but a significant decrease in TD treated diseased group was revealed post-treatment compared to the control group. Single subcutaneous injection of Tildipirosin causes an important decrease in MCV, and MCH levels in TD treated diseased group and decreasing in the MCHC of TD treated healthy group at day 7 compared to the control group. Tildipirosin causes no significant changes in Malondialdehyde (MDA) levels in TD-treated healthy while it increased in the TD-treated diseased group at all days after treatment compared to the control group. No significant changes occur in the superoxide dismutase (SOD) level of TD treated healthy group and TD treated diseased group compared to the control group. In conclusion, p. multocida is one of the most prevalent causes of BRD in Egypt, and tildipirosin was highly effective as a prophylactic and metaphylactic treatment against BRD cases caused by p. multocida, and it has a potentially anti-inflammatory effect.
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Optimizing the Biosorption Behavior of Ludwigia stolonifera in the Removal of Lead and Chromium Metal Ions from Synthetic Wastewater
No full textIn this study, a natural low-coast, efficient, and eco- bio-sorbent plant material (Ludwigia stolonifera), with both parts of the root and shoot, were studied for the removal of the cationic metal ions, lead Pb2+ and chromium Cr6+, via batch mode experiments to evaluate their maximum adsorption capacity, and held a comparison between the used bio-sorbent roots and shoots, based on the highest bio-sorption potential. Optimization of the bio-sorption parameters, such as contact time, pH, bio-sorbent (root and shoot) dosage, and initial ion concentration was conducted. The results indicated that 1.6 g of the used bio-sorbent shoot material removed 81.4% of Pb2+, and 77% of Cr6+ metal ions from liquid media under the conditions of 100 ppm of initial metal ions concentration at room temperature for 60 min of contact time with the static condition. Different isotherms and kinetic models were fit to the experimental data to understand the nature of the bio-sorption process. The experimental data were best fit by the pseudo-second-order kinetic model with a high correlation coefficient (R2 = 0.999), which reveals the chemisorption nature of the bio-sorption process. The chemical and structural analysis of the used bio-sorbent, before and after Cr6+ and Pb2+ bio-sorption, were performed using different techniques of characterization, such as Scanning Electron Microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). The used bio-sorbent proved to be a low-cost, efficient, and eco-friendly material to remove heavy metal ions from aqueous solutions
AN IMPROVED AND EFFICIENT RSA-BASED AUTHENTICATION SCHEME FOR HEALTHCARE SYSTEM
No full textOwing to the fast advancements of wireless communication, the telehealthcare platform makes it possible for patients to access healthcare services online. However, creating a secure and efficient authentication scheme for healthcare systems still presents a challenge. Several solutions have been introduced, but the majority are shortly found to be unable to meet some essential security standards. In this paper, we first revisit Dharminder et al.'s scheme, and prove its failure to provide mutual authentication, and pacient's untraceability, and its vulnerability to impersonation attacks. Furthermore, we suggest an improved RSA-based authentication scheme to mitigate the deficiencies observed in Dharminder et al.'s schema. The proposed scheme can provide mutual authentication, patients' anonymity and untraceability, and resist various types of attacks. Extensive evaluation on AVISPA proves the safeness of the proposed scheme against both passive and active attacks. Additionally, the proposed scheme is computationally and communicationally more efficient in comparison to existing schemes. [JJCIT 2024; 10(3.000): 247-264
Microbial Sensing and Removal of Heavy Metals: Bioelectrochemical Detection and Removal of Chromium(VI) and Cadmium(II)
No full textThe presence of inorganic pollutants such as Cadmium(II) and Chromium(VI) could destroy our environment and ecosystem. To overcome this problem, much attention was directed to microbial technology, whereas some microorganisms could resist the toxic effects and decrease pollutants concentration while the microbial viability is sustained. Therefore, we built up a complementary strategy to study the biofilm formation of isolated strains under the stress of heavy metals. As target resistive organisms, Rhizobium-MAP7 and Rhodotorula ALT72 were identified. However, Pontoea agglumerans strains were exploited as the susceptible organism to the heavy metal exposure. Among the methods of sensing and analysis, bioelectrochemical measurements showed the most effective tools to study the susceptibility and resistivity to the heavy metals. The tested Rhizobium strain showed higher ability of removal of heavy metals and more resistive to metals ions since its cell viability was not strongly inhibited by the toxic metal ions over various concentrations. On the other hand, electrochemically active biofilm exhibited higher bioelectrochemical signals in presence of heavy metals ions. So by using the two strains, especially Rhizobium-MAP7, the detection and removal of heavy metals Cr(VI) and Cd(II) is highly supported and recommended
Treadmill with Transcutaneous Electrical Nerve Stimulation Impact on Peak Velocity in Peripheral Arterial Disease: a Randomized Controlled Trial
No full textINTRODUCTION. Patients’ functional ability and quality of life are negatively impacted by peripheral arterial disease, which presents as incapacitating leg discomfort that affects walking. Although there are numerous methods for treating these symptoms, as treadmill training, individuals stopped because of their persistent pain. Transcutaneous electrical nerve stimulation (TENS) is a suggested treatment for pain relief.
AIM. This study aimed to determine how combined treadmill training and TENS affect walking distance, pain, and peak velocity in patients with peripheral artery disease.
MATERIALS AND METHODS. The study included 50 people with peripheral arterial disease (PAD), stage II Fontaine, and an ankle-brachial index of 0.90 or lower at rest or 0.73 or lower after exercise. Participants were randomly assigned to either supervised treadmill training (control group, n = 25) or supervised treadmill training combined with TENS (experimental group, n = 25) for 3 months. Doppler ultrasonography, and skeletal muscle oxygen saturation (SmO₂) were evaluated at baseline and after the study’s completion.
RESULTS AND DISCUSSION. The experimental group significantly improved all parameters being assessed more than the control group ( 0.05), except total hemoglobin, which did not differ statistically between groups.
CONCLUSION. This trial is the first to use treadmill training in conjunction with TENS as an adjuvant method to improve vascular function in people with PAD. Patients may use this strategy over time to improve their walking abilities, and it might be introduced into normal care in cardiovascular retraining
