1,720,965 research outputs found
Levels of Evidence in Endoscopic Ultrasonography: A Systematic Review.
A prolific trend currently designates endoscopic
ultrasonography (EUS) literature. We aimed to record all EUS-studies published
during the past decade and evaluate them in terms of scientific quality, creating
a stratification based on levels of evidence (LE). METHODS: All articles on EUS
published between January 2001 and December 2010 were retrieved using a Pubmed
and Cochrane Library search. Inclusion criteria were: original research papers
(randomized controlled trials-RCTs, prospective and retrospective studies),
meta-analyses, reviews and surveys pertinent to gastrointestinal EUS. Levels of
evidence (LE) were assessed using the North of England evidence-based guidelines.
RESULTS: Overall, 1,832 eligible articles were reviewed. The majority (46.1%) of
reports comprised retrospective descriptive studies (LE III). Expert reviews and
committee reports (LE IV) accounted for 28.9%, well-designed quasi-experimental
studies (LE IIb) for 20.1%, RCTs (LE Ib) for 2.4%, prospective controlled trials
(LE IIa) for 1.4%, and meta-analyses (LE Ia) for 1.1% of the total. High LE
(Ia-Ib) were assigned to loco-regional staging of luminal gastrointestinal
cancers; mediastinal staging of lung cancer; diagnostic work-up of solid
pancreatic tumors, suspected biliary obstruction and choledocholithiasis; celiac
plexus neurolysis; and pancreatic pseudocysts drainage. Intermediate to low LE
(IIa-IV) were assigned to submucosal tumors, pancreatic cysts, chronic
pancreatitis and novel therapeutic applications (pancreato-biliary drainage,
tumor ablation). CONCLUSIONS: Diagnostic and staging EUS has matured and has
proven its clinical impact on patient management. Therapeutic or interventional
EUS is still evolving and more quality research and data are needed to establish
EUS as the best next intervention to perform once firm evidence is available
Levels of evidence in endoscopic ultrasonography: a systematic review.
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Diagnosis of pancreatic cancer by contrast-harmonic endoscopic ultrasound (EUS): complementary and not competitive with EUS-guided fine-needle aspiration.
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Going Beyond Counting First Authors in Author Co-citation Analysis
The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
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