70 research outputs found
Measurement uncertainty and its implications for collaborative study method validation and method performance parameters
No full text
Re-examination of a conformational equilibrium isotope effect for hydrogen in 1,1,3,3-tetramethylcyclohexane - the importance of intrinsic isotope effects
No full textDiverse origins of conformational equilibrium isotope effects for hydrogen in 1,3-dioxans
No full textNeuroMET - SPECIAL MRS Reproducibility
No full textMagnetic Resonance Spectroscopy Data acquired in 9 healthy volunteers using a SPECIAL Localization with three different adiabatic inversion pulses (hyperbolic secant, WURST, GOIA) at a 7T Magnetom whole-body system (Siemens Healthineers, Erlangen, Germany). Every volunteer was examined 4 times (twice on day one including a repositioning between the measurements, and twice on day two a week later without repositioning between alike measurements) to investigate the repeatability and reproducibility. Please find more details in L.T. Riemann, C.S. Aigner, S.L.R. Ellison, R. Brühl, R. Mekle, S. Schmitter, O. Speck, G. Rose, B. Ittermann, A. Fillmer, "Assessment of Measurement Precision in Single Voxel Spectroscopy at 7 T: Towards Minimal Detectable Changes of Metabolite Concentrations in the Human Brain In-Vivo", Magn Reson Med DOI: DOI: 10.1002/mrm.29034 (in press).
Correspondence: [email protected], [email protected]
Code to generate the restricted maximum-likelihood estimation (REML) and the Bland-Altman (BA) plots of the spectral shape can be found under https://gitlab1.ptb.de/LRiemann/repeatability_reproducibility.git
Following data sets are provided:
1. ConcentrationsPaper-mrm29034_20211012_Riemann-Fillmer.xls
Data that is used with the R code to obtain the REML analysis of the metabolite concentrations. Note that the zeros indicate that the metabolite concentration could not be quantified.
2. RawData-mrm29034_20211012_Riemann-Fillmer.zip folder
Raw spectral data from Magnetom Siemens 7 T scanner
file names have the following structure: "SubjectNumber_Session_ScanBlock_Pulse.dat", e.g. "p1_T1_1_GOIA.dat"
3. npy-files-mrm29034_20211012_Riemann-Fillmer.zip folder
Spectral data in a python format to generate the BA plots with the shared code;
data names have the following structure: "SubjectNumber_PulseSessionScanBlock", e.g. "p1_GOIAT11.npy" for Subject p1, GOIA Pulse (AHS for hyperbolic secant), Session T1, ScanBlock 1
4. AnonymizedVolunteerData-mrm29034_20211012_Riemann-Fillmer.xlsx
Anonymized measurement data for each individual volunteer and measurement:
age, gender, transmit voltage, linewidth, peak voltages for all three pulses (HS, GOIA, WURST), CSF -, gray and white matter fraction in the scanned voxel for each subject.This project (18HLT09 NeuroMET2) has received funding from the EMPIR programme co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation programme
The indirect approach
No full textAid and conditionalities are the"carrots and sticks"of the conventional, direct approach to fostering economic development. The economic theory of agency is the most sophisticated treatment of the direct carrots-and-sticks approach to influencing human behavior. Considering the outcomes of the conventional approach, it might be worthwhile to explore alternative indirect approaches that focus on enabling clients to act more autonomously, rather than try for fuller control of clients'actions (or"agents"behaviors) with improved carrots and sticks. Are there inherent limitations in the direct approach that will not be addressed with better crafted"agency contracts"or closer monitoring of the agents? The author traces the intellectual history of indirect approaches from Socrates to modern thinkers, such as Wittgenstein, Gandhi, and McGregor. One theme of his survey is that constructivist and active-learning pedagogies constitute an indirect approach in which the teacher does not directly transmit knowledge to the learner, through training, and instruction. These pedagogies - translated into social and economic development as learning writ large - from the basis for an alternative indirect approach to fostering development. Actions have motives, just as beliefs have grounds, concludes the author. In the wide spectrum of human endeavor, there is only a fairly small"bandwidth"in which motives can be supplied by the carrots, and sticks of the direct approach (including agency theory, and market-driven activities as special cases of the direct approach to affecting behavior). Outside that spectrum, trying to use direct methods in a controlling manner, contradicts the motives for actions (and the grounds for beliefs) - like trying to"buy love."For higher activities, motives must come from within. Helpers can at best use an indirect approach to bring doers to the threshold; the doers have to do the rest, which makes the results their own.Public Health Promotion,Teaching and Learning,Curriculum&Instruction,Health Monitoring&Evaluation,Educational Sciences,Educational Sciences,Teaching and Learning,Health Monitoring&Evaluation,General Technology,Curriculum&Instruction
Validation Of Chromatographic Methods For The Determination Of Residues Of Veterinary Drugs In Foods [validação De Métodos Cromatográficos Para A Determinação De Resíduos De Medicamentos Veterinários Em Alimentos]
No full textDifferent agencies that supply validation guidelines worldwide establish almost the same parameters to be evaluated in the validation process of bioanalytical methods. However, they recommend different procedures, as well as establish different acceptance criteria. The present review delineates and discusses the stages involved in the validation procedures of bioanalytical methods designed for determining veterinary residues in food, explaining the main differences in the guidelines established for this purpose by the main regulatory agencies in the world.31511901198http://www.who.int/foodsafety/en/, acessada em Março 2007http://www. anvisa.gov.br, acessada em Janeiro 2007http://www. inmetro.gov.br, acessada em Janeiro 2007Agência Nacional de Vigilância Sanitária (ANVISA)Guia para Validação de Métodos Analíticos e Bioanalíticos, RE no 899, de 29/05/2003Normalização e Qualidade Industrial (INMETRO)(2003) Orientações sobre Validação de Métodos de Ensaios Químicos, DOQ-CGCRE-008, , Instituto Nacional de Metrologiahttp://goldbook.iupac.org/R05305.html, acessada em Janeiro 2007(1999) General Requirements for the Competence of Testing and Calibration Laboratories, , http://www.ich.org, International Standard Organization;, ISO/EC 17025, 8, acessada em Janeiro(1993) Guide to the Expression of Uncertainty in Measurements, , International Standard Organization ISO, Geneva(1995) Quantifying Uncertainty in Analytical Measurement, , EURACHEM;, Londonhttp://jecfa.ilsi.org/section1.htm#1, acessada em Abril 2007European CommissionOfficial Journal of the European Communities, 17/08/2002, L221/8-36International Conference on Harmonization (ICH)Validation of Analytical Procedures: Methodology, Q2B, Step 4, Consensus Guideline, 6 November 1996(2004) US Pharmacopeia 27, , United States Pharmacopeia (USP) Convention;, RockvilleCollins, C.H., Braga, G.L., Bonato, P.S., (2005) Fundamentos de Cromatografia, , Editora UNICAMP: CampinasCenter for Drug Evaluation and Research, Center for Veterinary Medicine, Department of Health and Human Services (2001) Guidance for Industry, Bioananalytical Method Validation, , United States Food and Drug Administration US-FDA, MayThompson, M., Stephen, L.R., Wood, R., (2002) Pure Appl. Chem, 74, p. 835(1997) Validation of Analytical Methods for Food Control, , Food and Agriculture Organization of the United Nations FAO, DecemberHuber, L., (1998) LC-GC Int, 11, p. 96Rogatsky, E., Stein, S., (2005) J. Am. Soc. Mass Spectrom, 16, p. 1757Thompson, M., Ellison, S.R., Wood, R., (2006) Pure Appl. Chem, 78, p. 145http://www.inmetro.gov.br/kits/ctle05_protocolo.pdf, acessada em Março 2007Miller, J.C., Miller, J.N., (1993) Statistics for Analytical Chemistry, , Ellis HorwoodNew Yor
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