4,640 research outputs found
Stephen F. Austin.
No full textBrief biographical narratives about Ellis P. Bean and Stephen F. Austin
Christopher Maginn / Steven G. Ellis, The Tudor Discovery of Ireland
No full textAls im Jahr 1485 mit Heinrich VII. der erste Tudorkönig den englischen Thron bestieg, galt Irland als unbedeutendes, von gälischen Barbaren beherrschtes Randgebiet. Auf der politischen Agenda der jungen Dynastie gewann die Insel nur langsam an Bedeutung. Irland, so die zentrale Überlegung der beiden Autoren Christopher Maginn und Stephen G. Ellis, war also ein weißer Fleck auf der englischen Landkarte, der in der frühen Tudorzeit erst noch besucht, beschrieben und entdeckt werden musste. Belastbare Informationen wurden in London erst nach und nach verfügbar, zumeist auf der Grundlage schriftlicher Berichte und Traktate. Wie dieses Wissen über Irland gewonnen und in der höfischen Gesellschaft in politisches Kapital umgemünzt wurde, wollen Maginn und Ellis in ihrer 2015 erschienenen Untersuchung zeigen
Strategic approaches in coronary intervention, 3rd Ed./ Edit. : Stephen G. Ellis
No full textxiv, 546 hal. : ill.; 27 cm
Strategic approaches in coronary intervention, 3rd Ed./ Edit. : Stephen G. Ellis
No full textxiv, 546 hal. : ill.; 27 cm
The effect of oxidation on the stability of G-quadruplex DNA : implications for oncogene expression
No full textG-quadruplexes (G4-DNA) are a class of secondary structures formed from Guanine rich sequences. In recent years these structures have been implicated in both telomere maintenance and oncogene expression, and have been shown to be abundant in upstream promoter regions and at telomeric ends.
The mutagenic properties of oxidative stress on DNA have been widely studied, as has the association with carcinogenesis. The oxidation of deoxyguanosine to 8-oxo-2’deoxyguanosine (8-oxo-dG) is the most common result when DNA is under oxidative stress and as such, the G-rich sequences that form G-quadruplexes can be viewed as potential “hot-spots” for DNA oxidation. We propose that oxidation may destabilise the G-quadruplex structure, leading to its unfolding into the duplex structure, affecting gene expression. This would imply a possible mechanism by which oxidation may impact on oncogene expression.
This project used both in silico and in vitro methods to observe the effect of oxidation on the G-quadruplex structure and the consequences in oncogene expression, using two biologically relevant G-quadruplex structures, those found in the promoter regions of the proto-oncogenes c-Myc and c-Kit as proof of concept.
Molecular dynamics (MD) simulations were performed (isothermic, isobaric 500ns unrestrained simulation in explicit solvent and counterions) on the c-Kit and c-Myc G-quadruplex structures with and without 8-oxo-dG incorporated into the central tetrad. FRET experiments were performed on these same structures, observing the conformation of sequences known to form G-quadruplexes under near physiological conditions and subjected to oxidative stress, through Fenton chemistry. Gene expression data analyses were also performed to evaluate the prevalence of different G-quadruplex forming motifs (GQMs) in genes affected by oxidation.Although no relevant information was gained from the FRET experiments, the MD results constitute the longest simulations of this type performed on the c-Myc and c-Kit G-quadruplex structures published to date and predict the high stability of these structures under normal physiological conditions. They also clearly demonstrate a destabilising effect of oxidation on G-quadruplex structures, with the extent of the effect dependent on the structure oxidised.
Furthermore, gene expression data analysis showed that genes whose expression is significantly altered when subjected to oxidative stress are statisticallymore likely to contain a GQM than the remainder of the genome, through the use of significance testing.
These findings demonstrate a differential effect of oxidation on G-quadruplexes, likely dependent on other known characteristics affecting G4 stability such as loop length and sequence. Results also point towards this mechanism affecting gene expression. This is suggestive of a novel route for oxidation mediated carcinogenesis, through upregulation of oncogene expression or possibly downregulation of tumour suppression genes
The Grothendieck-Cousin complex on G/B x G/B
No full textIn his 1978 paper, The Grothendieck-Cousin complex of an induced representation, G. Kempf computes the Cousin complex corresponding to an induced representation of a reductive algebraic group G. His technique uses the geometry of the homogeneous space G/B, B being a Borel subgroup of G. The complex gives a resolution by B-modules, which easily yields the Weyl character formula.Instead of considering G/B, we analyze the analagous situation for . The Cousin complex corresponding to an induced representation in this case consists of G-modules. We are able to study the terms of the complex by exploiting parallels between the B-action on G/B and the G-action on --there is a natural one-to-one correspondence between the orbits of these actions. Our work here is greatly simplified by reducing to the affine situation and applying the theory of A-G modules. We construct a spectral sequence relating the terms of the complexes. Finally, an application to the theory of D-modules is given.Made available in DSpace on 2011-05-07T12:16:39Z (GMT). No. of bitstreams: 2
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Lester G. Wells: An Appreciation
No full textThis intimate portrait of Syracuse\u27s Lester G. Wells tells the story of a committed scholar, who contributed important scholarship on the famous and enigmatic author Stephen Crane, as well as works on the Oneida Communiry. Mr. Wells also organized the Lena R. Arents Rare Book Room in 1946, and became Syracuse University\u27s first Rare Book Librarian
Impact of Coupling an Ocean Model to WRF Nor’easter Simulations
No full textThe impact of ocean–atmosphere coupling and its possible seasonal dependence upon Weather Research and Forecasting (WRF) Model simulations of seven, wintertime cyclone events was investigated. Model simulations were identical aside from the degree of ocean model coupling (static SSTs, 1D mixed layer model, full-physics 3D ocean model). Both 1D and 3D ocean model coupling simulations show that SSTs following the passage of a nor’easter did tend to cool more strongly during the early season (October–December) and were more likely to warm late in the season (February–April). Model simulations produce SST differences of up to 1.14 K, but this change did not lead to significant changes in storm track ( 1) and have low-to-moderate threat scores (0.31–0.59). Analysis of the storm environment and the overall simulation failed to reveal any statistically significant differences in model error attributable to ocean–atmosphere coupling. Despite this result, ocean model coupling can reduce dynamical field error at a single level by up to 20%, and this was slightly greater (1%–2%) with 3D ocean model coupling as compared to 1D ocean model coupling. Thus, while 3D ocean model coupling tended to generally produce more realistic simulations, its impact would likely be more profound for longer-term simulations.© Copyright 2015 American Meteorological Society (AMS). Permission to use figures, tables, and brief excerpts from this work in scientific and educational works is hereby granted provided that the source is acknowledged. Any use of material in this work that is determined to be “fair use” under Section 107 of the U.S. Copyright Act September 2010 Page 2 or that satisfies the conditions specified in Section 108 of the U.S. Copyright Act (17 USC §108, as revised by P.L. 94-553) does not require the AMS’s permission. Republication, systematic reproduction, posting in electronic form, such as on a web site or in a searchable database, or other uses of this material, except as exempted by the above statement, requires written permission or a license from the AMS. Additional details are provided in the AMS Copyright Policy, available on the AMS Web site located at (http://www.ametsoc.org/) or from the AMS at 617-227-2425 or [email protected] reviewe
Impact of coupling an ocean model to WRF nor’easter simulations
No full textThe impact of ocean-atmosphere coupling and its possible seasonal dependence upon Weather Research and Forecasting (WRF) model simulations of seven, winter-time cyclone events was investigated. Model simulations were identical aside from the degree of ocean model coupling (static SSTs, 1D mixed-layer model, full-physics 3D ocean model). Both 1D and 3D ocean model coupling simulations show that SSTs following the passage of a nor’easter did tend to cool more strongly during the early season (Oct-Dec) and were more likely to warm late in the season (Feb-Apr). Model simulations produce SST differences of up to 1.14 K, but this change did not lead to significant change in storm track ( 1) and have low-to-moderate threat scores (0.31 – 0.59). Analysis of the storm environment and the overall simulation failed to reveal any statistically significant differences in model error attributable to ocean-atmosphere coupling. Despite this result, ocean model coupling can reduce dynamical field error at a single level by up to 20%, and this was slightly greater (1-2%) with 3D ocean model coupling as compared to 1D ocean model coupling. Thus, while 3D ocean model coupling tended to generally produce more realistic simulations, its impact would likely be more profound for longer-term simulations.© Copyright 2015 American Meteorological Society (AMS). Permission to use figures, tables, and brief excerpts from this work in scientific and educational works is hereby granted provided that the source is acknowledged. Any use of material in this work that is determined to be “fair use” under Section 107 of the U.S. Copyright Act September 2010 Page 2 or that satisfies the conditions specified in Section 108 of the U.S. Copyright Act (17 USC §108, as revised by P.L. 94-553) does not require the AMS’s permission. Republication, systematic reproduction, posting in electronic form, such as on a web site or in a searchable database, or other uses of this material, except as exempted by the above statement, requires written permission or a license from the AMS. Additional details are provided in the AMS Copyright Policy, available on the AMS Web site located at (http://www.ametsoc.org/) or from the AMS at 617-227-2425 or [email protected] reviewe
"But things are coming small small, that's how we're seeing it" : agency of a Liberian women's organization in a context of insecurity, scarcity, and uncertainty
No full text- …
