4,656 research outputs found
Sigh
No full textA fixed media piece arising from a collaboration with violinist and keyboard player Claire Ellis. The work was created using an iterative process of improvisation and electronic manipulation
Sixty Years of Community: St. Olaf Catholic Parish in Eau Claire, Wisconsin, 1952-2012
No full textThis paper will explore how the parish community of St. Olaf in Eau Claire, Wisconsin, established in 1952, reflects the Roman Catholic Church, specifically at the local, state, and national levels in the United States. It will also discuss the various changes that have occurred in the past 60 years of its history in terms of the various locations of worship for the members, the growth of the community outreach programs, and the effects of the Second Vatican Council. This ecumenical council was a meeting of Catholic bishops from around the whole that brought reform to the Catholic Church and affected the relationship of the Catholic Church to the world. The parish at St. Olaf has grown from having only 125 families in 1952 to over 1,000 families in 2012
From Mansions to Towers: A History of Residence Halls at the University of Wisconsin-Eau Claire
No full textThe construction of the University of Wisconsin-Eau Claire's residence halls has generally followed that of the national trend. The school struggled to find enough funds to build residence halls in the early years. Eventually, student housing was in needed so badly that the school had no choice but to provide housing for the students. In 1947, the Dulany mansion was purchased and remodeled by the school. This building served as the University's first resident hall. Since then, eleven resident halls have been built on campus with one more being planned. Life in these residence halls have changed dramatically over time. In the 1960's, the students protested and eventually the strict rules of in loco parentis faded away. After this, students enjoyed the freedoms of new technologies, relaxed rules, and more professional housing leaders. Today, UW-Eau Claire is a thriving university. UW-Eau Claire has been recognized by many as a top school in the Midwest. Much of the success can be attributed to the residence halls and the happiness of the students. My paper will provide UW-Eau Claire and its students with a cohesive history of the residence halls on campus and will also show how student life has evolved since the University was first established
Claire Tham (1967-)
No full textAs an author, Claire Tham has this far been less concerned to observe the canons of English literature and more concerned to explore its creative possibilities and its adaptability. She also articulates a significant viewpoint about national and personal identity, about cultural tensions in a dynamic urban centre in transition, and about the.flip-side of Singapore’s prodigious prosperity
Claire Wheeler: Fearless Psychologist
No full textFearless physician/psychologist Claire is a clinical psychologist and former emergency room doctor. As a full-time instructor at PSU’s School of Community Health she teaches classes in disease physiology, mind-body medicine, nutrition and health psychology. She is the author of 10 Simple Solutions to Stress, published in 2007. She’ll reveal some of the mysteries of how negative thoughts can affect your health, and teach techniques to avoid them. Think “cognitive reframing.”https://pdxscholar.library.pdx.edu/pdxtalks/1020/thumbnail.jp
Jurisprudence - the bystander to crime
No full textThe author raises questions about the predicament of a bystander to a serious crime who does not intervene to oppose it. Article by Claire Valier (Lecturer in Law, University of London) published in Amicus Curiae - Journal of the Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London
Crank by Ben Ellis
No full textPoster advertising Crank by Ben Ellis, directed by Claire Thomas and presented by Kickstomp Theatre at the Guild Theatre, University of Melbourne
La Fabrique des classiques africains: écrivains d’Afrique subsaharienne francophone . Par Ducournau Claire
No full textThis is a pre-copyedited, author-produced PDF of an article accepted for publication in French Studies following peer review. The version of record Claire H Griffiths (2018) La Fabrique des classiques africains : ecrivains d'Afrique subsaharienne francophone par Claire Ducournau, French Studies, Volume 72, Issue 2, 1 April 2018, Pages 318–319 is available online at: https://doi.org/10.1093/fs/kny023The review article evaluates major new scholarship on the development of the French literary system in colonial and postcolonial Africa and its impact on Francophone writing
Investigating the Mechanistic Roles of Conserved Residues in Cysteine Dioxygenase: How a Hydrogen-bonding Network and a Rogue Cysteine Effect L-cysteine Oxidation and Crosslink Formation
No full textCysteine Dioxygenase (CDO) catalyzes the oxidation of L-cysteine to L-cysteine sulfinic acid utilizing iron as a cofactor. Adjacent to the iron center is a protein-derived thioether crosslink formed by a cysteine (Cys93) and a tyrosine (Tyr157) residue. The crosslinked isoform of CDO increases catalytic activity ~5-fold compared to non-crosslinked CDO. Tyr157 forms a hydrogen-bonding network with His155 and Ser153 which has been proposed to participate in cysteine oxidation. Substitutions of His155 were made in CDO to evaluate the importance of the hydrogen-bonding network in both cysteine oxidation and crosslink formation. All substitutions resulted in minimal catalytic activity compared to wild-type CDO. Even though H155Q CDO showed minimal catalytic activity, the variant was able to generate the crosslink as effectively as wild-type CDO, while crosslink formation was limited with the H155A and H155E CDO variants. All substitutions of His155 altered the microenvironment of the metal coordination center of CDO. The different effects of the His155 CDO variants on crosslink formation and cysteine oxidation suggest the hydrogen-bonding network plays dual roles due to the distinct chemical steps utilized in these processes. Located ~8 Å away from the iron center is a conserved Cys (Cys164) residue at the opening to the active site. Cys164 does not participate in any intramolecular disulfide bonds and exists as a free thiol. Several bacterial CDO homologs contain either an Arg or a Met residue at a comparable position as Cys164 in mammals. Therefore, it has been speculated that Cys164 and amino acids at comparable positions could contribute to the substrate specificity of mammalian and bacterial CDO. Other studies have shown that Cys164 is involved in a disulfide bond with a free Cys in three-dimensional structures which suggested that Cys164 may serve as a redox switch in CDO. However, this hypothesis has not been adequately evaluated. Multiple variants of Cys164 in CDO were constructed to evaluate the role of Cys164 in catalysis, crosslink formation, and oxidative regulation. All Cys164 CDO variants displayed diminished activity compared to wild-type CDO. Crosslink formation studies showed that C164A CDO was the only Cys164 variant that could generate the fully crosslinked species at increased L-cysteine substrate concentrations similar to wild-type CDO. In addition, wild-type, C164A, non-crosslinked wild-type, and non-crosslinked C164A CDO did not appear to be modified by hydrogen peroxide or L-cysteine. Although Cys164 is not in the active site, these studies suggest that Cys164 likely plays a key role in L-cysteine substrate oxidation. Since Cys164 is located at the opening of the active site, it may regulate accessibility of the L-cysteine substrate to the active site. Both of these studies evaluated the mechanistic roles of conserved residues in CDO. The hydrogen-bonding network appears to stabilize iron-oxo intermediates through hydrogen-bonding interactions during catalysis. The Cys164 residue may act as a gate-keeper by regulating accessibility of the L-cysteine substrate during catalysis and crosslink formation. These studies also provided a foundation for future studies regarding the elucidation of the L-cysteine oxidation and crosslink formation mechanisms
Why hedge? Extent, nature, and determinants of derivative usage in U.S. municipalities
No full textUsing a hand-collected dataset of over 300 observations of large U.S. cities and counties, this paper investigates the extent, nature and determinants of derivatives usage in the municipal sector.Over half of our sample entities engage in derivative transactions and a vast majority of these transactions are intended to manage interest rate risk. Swaps, by far, are the most popular derivative instrument. In terms of the determinants of derivative usage,we find that the propensity to use derivatives as well as the extent of derivative usage is higher for municipalities that are larger and more financially constrained. We do not find growth to be related to municipal derivative usage. Contrary to suggestions made in the popular press, we fail to find managerial opportunism to be a significant factor in municipal derivative usage. We also find that more sophisticated managers of large municipalities and less sophisticated managers of small municipalities are more likely to engage in derivative transactions.Peer reviewe
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