240 research outputs found
Dose-response relationship between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and diabetes mellitus: A meta-analysis
No full textWe systematically evaluated studies published through May 2014 in which investigators assessed the dose-response relationship between serum levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the occurrence of diabetes mellitus (DM), and we investigated the extent and sources of interstudy heterogeneity. The dose-response relationship between serum TCDD and DM across studies was examined using 2 dependent variables: an exposure level-specific proportion of persons with DM and a corresponding natural log-transformed ratio measure of the association between TCDD and DM. Regression slopes for each dependent variable were obtained for each study and included in a random-effects meta-analysis. Sensitivity analyses were used to assess the influence of inclusion and exclusion decisions, and sources of heterogeneity were explored using meta-regression models and a series of subanalyses. None of the summary estimates in the main models or in the sensitivity analyses indicated a statistically significant association. We found a pronounced dichotomy: a positive dose-response in cross-sectional studies of populations with low-level TCDD exposures (serum concentrations <10 pg/g lipid) and heterogeneous, but on balance null, results for prospective studies of persons with high prediagnosis TCDD body burdens. Considering the discrepancy of results for low current versus high past TCDD levels, the available data do not indicate that increasing TCDD exposure is associated with an increased risk of DM. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health
Homogenisation method based on energy conservation and independent of boundary conditions
No full textThe foundation of homogenisation methods rests on the postulate of Hill–Mandel, describing energy consistency throughout the transition of scales. The consideration of this principle is therefore crucial in the discipline of Digital Rock Physics which focuses on the upscaling of rock properties. For this reason, numerous studies have developed numerical schemes for porous media to enforce the Hill–Mandel condition to be respected. The most common method is to impose specific boundary conditions, such as periodic ones. However, these boundary conditions influence both the effective property and the size of the REV. The recent study of Thovert and Mourzenko (2020) has shown that most boundary conditions still result in the same intrinsic effective physical property if the averaging is applied outside the range of the boundary layer. From this discovery, it becomes logical to question the status of Hill–Mandel postulate in porous media when homogenising away from the boundary. In this contribution, we simulate Stokes flow through random packings of spheres and a range of rock microstructures. For each, we plot the evolution of the ratio micro- vs macro-scale of the energy of the fluid transport outside the boundary layer, for a growing subsample size of porous media. Here, we prove that we naturally find energy consistency across scales when reaching the size of the Representative Elementary Volume (REV), which is a known condition for rigorous upscaling. Furthermore, we show that this index for the energy consistency is a more accurate indicator of REV convergence since the mean value is already known to be unitary.Applied Mechanic
Bobbles and values: An ethnography of de-bobbling garments in postsocialist urban Romania
No full textBased on research on clothing consumption in a provincial Romanian town, this article focuses on bobbling (pilling) and on reflections on its appearances and progression. Bobbling is considered an index of a faulty or decaying materiality, and an index of usage and, possibly, carelessness and hardship. It limits an individual’s ability to project a desired self. It hints at an individual’s inability to present a renewed self. It not only disrupts a common process of value creation through the act of dressing, but also exposes a disputed process of value creation through the consumption of certain objects. It foregrounds a predisposition to equate the value of objects with the value of people. It affects a sense of self-worth. The author demonstrates that a preoccupation with bobbling reflects deeper concerns and frequent deliberations over value in postsocialist Romania
Business Cycle from The Viewpoint of Monetary and Credit Variables
No full textThe master's thesis critically analyses the works of John Maynard Keynes and Friedrich August von Hayek concering the explanation of business cycles based on monetary determinants. The analysis is primarily based on J. M. Keynes's Treatise on Money (1930) and Prices and Production (1935) author of which is F. A. Hayek. The thesis, on one hand, refutes the main explanation of the cause of business cycles of the Austrian business cycle theory and, on the other hand, it argues the imcompatibility of the main analytical tool of Treatise with the theory of innovation by J. A. Schumpeter
Homogenization Techniques in Digital Rock Physics: Revisiting the Hill-Mandel principle and determination of the evolution law of the convergence cone
No full textThe first part of the thesis explores the process of homogenization, particularly for the permeability properties of rock samples. The Hill-Mandel postulate of energy consistency throughout the transitioning of scales is revisited since traditional homogenization methods rely on applying specific boundary conditions to enforce energy consistency. However, it is shown that the applied boundary conditions influence the effective physical parameter and provide upper or lower bound estimations. Recently, it is shown that these boundary conditions influence a layer near the boundary of the sample and that homogenization applied on the subsample away from this boundary layer is not affected by the boundary conditions.The research focuses on energy consistency by studying the evolution of the energy within the intrinsic subsample, away from the boundaries. With the help of Finite Element simulations of Stokes-flow through idealized structures, the energy of the fluid is traced without the influences of grain properties on the energy dissipation. By plotting the ratio of the energy dissipation of the macro- and micro-scale, it is shown that the energy consistency is not found within small subsamples. Yet, with a growing subsample, energy consistency is achieved naturally, without the enforcement of boundary conditions. As a result, it is concluded that the energy consistency is found at the Representative Elementary Volume (REV), which is a similar requirement as for traditional homogenization methods. The study of the natural energy consistency in idealized microstructures is extended to real microstructures, which include more natural heterogeneities, such as grain properties. It is shown that energy consistency is also found with the natural heterogeneities included, albeit with a slower convergence. For the homogenization of the permeability of a sample, the energy ratio is now known to be unitary, which can be used as an accurate indicator to determine the size of the REV.The second part of the thesis explores the process of determining the size of the REV, which is a common, yet essential practice in Digital Rock Physics. Currently, this is an extensive exercise, involving many and large-size simulations to trace the convergence of the physical property and requires a lot of computational resources and time. Numerical-statistical studies have shown that the convergence of the REV visualizes in a cone-like shape. By plotting the convergence for both the permeability and the energy dissipation ratio for idealized microstructures, this study analyses the shape and evolution of the cone of convergence. From this, the generic evolution law of the convergence is determined. It is shown that the asymmetrical convergence cone is described with a log-normal distribution, with a stable mean throughout the evolution of the cone and a variance for each sample size. The evolution of the variance is described with the law of large numbers, taking into account a reference value. This makes it possible to determine the size of the REV. Since the statistical method applies, information about the error of the fit, the error of the determined homogenized property, and the error of the size of the REV is provided. The study is extended to real microstructures to validate whether the determined evolution law applies when natural heterogeneities are included. It is shown that the evolution law still accurately describes the REV's convergence. Therefore, the REV's size of real rock samples can also be determined. Even when the REV is not included within the sample, the evolution law can provide an estimate of the size of the REV or the homogenized property. By using the cone of convergence, it is not necessary to run simulations on the full sample to find the REV, which is computationally expensive, instead running a number of simulations on small subsamples is sufficient, which saves both time and computational resources. It also unlocks the possibility to find the REV for high-resolution samples, as splitting the sample into subsamples allows for smaller simulations.Civil Engineerin
AN EVALUATION OF THE FEASIBILITY OF AN ONLINE FAMILY-BASED INDICATED PREVENTION PROGRAM FOR ADOLESCENT EATING DISORDERS
No full textAdolescent eating disorders are highly impairing class of mental illness, marked by chronicity and recurrence. Data indicate that early intervention, before anorexia nervosa (AN) or bulimia nervosa (BN) symptoms become entrenched, leads to an increased likelihood of positive outcomes (Fisher, Schneider, Burns, Symons & Mandel 2001; Le Grange, Loeb, Van Orman & Jellar, 2004). As such, numerous prevention programs have been developed for adolescent eating disorders, with mixed success (Shaw, 2008, Stice, Shaw & Marti, 2007). Most recently, programs have utilized the technology of the Internet to make prevention and early intervention more accessible and cost effective for affected teens and families. The current study assessed the feasibility of an original Internet-based indicated prevention program for families of adolescents with subsyndromal eating disorders. The program was based on the empirically-supported Family Based Treatment (FBT) for adolescent AN and BN. Seven families (comprised of 7 caregivers and 7 adolescents with subthreshold levels of eating disorder symptoms) were enrolled in the study, and 4 families successfully completed all program requirements. Four separate aims were assessed including: evaluation of program acceptability, identification of recruitment and retention patterns, assessment of program compliance and dosage received, and analysis of preliminary outcomes. Results suggested that the program was acceptable to all participants, and that the program format and content were positively received. Preliminary outcome data was limited due to the small sample size, however, descriptive analyses showed that the program had a significant effect on the reduction of all cognitive and behavioral eating disorder symptoms, as well as on the reduction of adolescent depressive symptoms. Adolescent ix self esteem was not significantly impacted by program participation. Compliance results were less straightforward. Program adherence was mixed, and further investigation is needed to clarify patterns of compliance and retention. Finally, the recruitment strategies used were found to not be feasible. Despite a wide-ranging and multi-faceted recruitment strategy, rates were very slow. Further, a large percentage of interested potential participants had to be excluded, calling into question the appropriateness of the applicant pool that was accessed through the implemented program of recruitment. Implications of these findings, possible explanations and suggestions for future research are discussed.Ph.D. in Psychology, December 201
The shocking transit of WASP-12b : modelling the observed early ingress in the near ultraviolet
No full text4 pages, 2 figuresNear ultraviolet observations of WASP-12b have revealed an early ingress compared to the optical transit lightcurve. This has been interpreted as due to the presence of a magnetospheric bow shock which forms when the relative velocity of the planetary and stellar material is supersonic. We aim to reproduce this observed early ingress by modelling the stellar wind (or coronal plasma) in order to derive the speed and density of the material at the planetary orbital radius. From this we determine the orientation of the shock and the density of compressed plasma behind it. With this model for the density structure surrounding the planet we perform Monte Carlo radiation transfer simulations of the near UV transits of WASP-12b with and without a bow shock. We find that we can reproduce the transit lightcurves with a wide range of plasma temperatures, shock geometries and optical depths. Our results support the hypothesis that a bow shock could explain the observed early ingress.Peer reviewe
Aggregation in solutions of poly-gamma-benzyl-L-glutamate monitored by static and dynamic light scattering
No full textApplied Science
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