347 research outputs found
Signs : launching a journal, building an interdisciplinary field : the legacies of Signs
No full textTo mark the thirtieth anniversary of 'Signs: journal of women in culture and society' and the arrival of its editorial office at Rutgers University, Douglass Library hosted a celebration that included a panel discussion with past journal editors and an archival exhibition. The editors came together to discuss their experiences during the journal's formative years through its later accreditation as a top international journal in women's studies. They conveyed the significance of Signs throughout their careers, underscoring its influence in the institutionalization of women's studies in academia. The exhibition included items from the Signs Archives within Rutgers Libraries' Special Collections and University Archives that trace the emergence and development of the feminist intellectual community and the critical role played by Rutgers scholars in the process.Mary (M.E.) Hawkesworth (4 min.) -- Holly Smith (4 min.) -- Andrew Baumann (3 min.) -- Mary (M.E.) Hawkesworth (18 min.) -- Catharaine Stimpson (12 min.) -- Barbara Charlesworth Gelpi (11 min.) -- Barbara Laslett (12 min.) -- Ruth-Ellen Boetcher Joeres (7 min.) -- Carolyn Allen (7 min.) -- Kathryn Norberb (5 min.) -- Question and answer session (25 min.)Filmed at the Douglas Library, Rutgers University, on April 6, 2006
Educare alla citadinanza democratica : Tra teoria e prassi : in memoria di Bruno Schettini
No full textQuesto mio scritto è in onore del fu Bruno Schettini, amico e collega degli ultimi 5 anni, ora che siamo ancora in attesa di ulteriori sviluppi da parte della Comunità Europea nel campo dell’istruzione permanente ben dieci anni dopo la pubblicazione del Memorandum su questo argomento. Bisogna ancora vedere se nuove strade si dipartiranno dall‟opinione dominante dello scorso decennio e se siano state recepite le lezioni che scaturiscono dalle critiche pubblicate da un certo numero di scrittori, incluso un libro scritto da Ettore Gelpi che Bruno Schettini aiutò a pubblicare in italiano e per il quale scrisse una introduzione molto perspicace. In questo intervento intendo fornire un riassunto del concetto di lifelong learning e di come l‟OECD abbia mutato le sue origini nate in seno all‟UNESCO, ma più specificamente dalle mutazione dovute ai 6 messaggi emanati dalla Comunità Europea e contenuti nel Memorandum on Lifelong Learning . Nello stesso tempo cercherò di spiegare come il discorso su questo argomento possa essere portato avanti fino a diventare un vero e proprio contributo al rafforzamento della democrazia.peer-reviewe
Adrienne Rich : towards a feminist poetics
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Comunicação e Expressã
Lymphomatosis cerebri and anti-NMDAR antibodies: A unique constellation
No full textLetter to the Edito
Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt-Jakob disease
No full textBrunella Eruli(II Hommage a Ettore Gelpi, Part 1 Memorial Articles for Ettore Gelpi)
No full textこの論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました
Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt-Jakob disease
No full textA novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features
No full textAbstract Background Parkinson’s disease (PD) affects millions of people worldwide, but only 5–10% of patients suffer from a monogenic form of the disease with Mendelian inheritance. SNCA, the gene encoding for the protein alpha-synuclein (aSyn), was the first to be associated with familial forms of PD and, since then, several missense variants and multiplications of the SNCA gene have been established as rare causes of autosomal dominant forms of PD. Aim and methods A patient carrying aSyn missense mutation and his family members were studied. We present the clinical features, genetic testing - whole exome sequencing (WES), and neuropathological findings. The functional consequences of this aSyn variant were extensively investigated using biochemical, biophysical, and cellular assays. Results The patient exhibited a complex neurodegenerative disease that included generalized myocloni, bradykinesia, dystonia of the left arm and apraxia. WES identified a novel heterozygous SNCA variant (cDNA 40G>A; protein G14R). Neuropathological examination showed extensive atypical aSyn pathology with frontotemporal lobar degeneration (FTLD) and nigral degeneration pattern with abundant ring-like neuronal inclusions, and few oligodendroglial inclusions. Sanger sequencing confirmed the SNCA variant in the healthy, elderly parent of the patient patient suggesting incomplete penetrance. NMR studies suggest that the G14R mutation induces a local structural alteration in aSyn, and lower thioflavin T binding in in vitro fibrillization assays. Interestingly, the G14R aSyn fibers display different fibrillar morphologies as revealed by cryo-electron microscopy. Cellular studies of the G14R variant revealed increased inclusion formation, enhanced membrane association, and impaired dynamic reversibility of serine-129 phosphorylation. Summary The atypical neuropathological features observed, which are reminiscent of those observed for the G51D aSyn variant, suggest a causal role of the SNCA variant with a distinct clinical and pathological phenotype, which is further supported by the properties of the mutant aSyn, compatible with the strain hypothesis of proteinopathies
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