145,625 research outputs found
Whole home exercise intervention for depression in older care home residents (the OPERA study) : a process evaluation
No full textBackground:
The ‘Older People’s Exercise intervention in Residential and nursing Accommodation’ (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We report a process evaluation exploring potential explanations for the lack of effect.
Methods:
The OPERA trial included over 1,000 residents in 78 care homes in the UK. We used a mixed methods approach including quantitative data collected from all homes. In eight case study homes, we carried out repeated periods of observation and interviews with residents, care staff and managers. At the end of the intervention, we held focus groups with OPERA research staff. We reported our first findings before the trial outcome was known.
Results:
Homes showed large variations in activity at baseline and throughout the trial. Overall attendance rate at the group exercise sessions was low (50%). We considered two issues that might explain the negative outcome: whether the intervention changed the culture of the homes, and whether the residents engaged with the intervention. We found low levels of staff training, few home champions for the intervention and a culture that prioritised protecting residents from harm over encouraging activity. The trial team delivered 3,191 exercise groups but only 36% of participants attended at least 1 group per week and depressed residents attended significantly fewer groups than those who were not depressed. Residents were very frail and therefore most groups only included seated exercises.
Conclusions:
The intervention did not change the culture of the homes and, in the case study homes, activity levels did not change outside the exercise groups. Residents did not engage in the exercise groups at a sufficient level, and this was particularly true for those with depressive symptoms at baseline. The physical and mental frailty of care home residents may make it impossible to deliver a sufficiently intense exercise intervention to impact on depressive symptoms
Thiamine responsive megaloblastic anemia: a novel SLC19A2 compound heterozygous mutation in two siblings
No full textThiamine responsive megaloblastic anemia (TRMA) is an autosomal recessive disease caused by loss of function mutations in the SLC19A2 gene. TRMA is characterized by anemia, deafness, and diabetes. In some cases, optic atrophy or more rarely retinitis pigmentosa is noted. We now report two sisters, the eldest of which presented to a different hospital during childhood with sensorineural deafness, which was treated with a hearing prosthesis, insulin requiring diabetes, retinitis pigmentosa, optic atrophy, and macrocytic anemia. These features initially suggested a clinical diagnosis of Wolfram syndrome (WS). Therapy with thiamine was initiated which resulted in the resolution of the anemia. The younger sister, who was affected with sensorineural deafness, was referred to our hospital for non-autoimmune diabetes. She was found to have macrocytosis and ocular abnormalities. Because a diagnosis of TRMA was suspected, therapy with insulin and thiamine was started. Sequencing analysis of the SLC19A2 gene identified a compound heterozygous mutation p.Y81X/p.L457X (c.242insA/c.1370delT) in both sisters. Non-autoimmune diabetes associated with deafness and macrocytosis, without anemia, suggests a diagnosis of TRMA. Patients clinically diagnosed with WS with anemia and/or macrocytosis should be reevaluated for TRMA
Thiamine responsive megaloblastic anemia: a novel SLC19A2 compound heterozygous mutation in two siblings.
No full text<i>No se sabe</i>: entrevista a Lucas Gagliardi
No full textEntrevista al Licenciado y Profesor en Letras (UNLP) Lucas Gagliardi. Se especializa en literatura en lengua inglesa y en crítica genética. Se desempeña como profesor en la Universidad Pedagógica (UNIPE), en institutos de formación docente y escuelas secundarias. Ha participado en proyectos de investigación sobre archivos de escritores, publicaciones impresas. Participa en el programa de voluntariado universitario de la Facultad de Trabajo Social (UNLP) en articulación con la Biblioteca Ambulante del Hospital de Niños dictando talleres de lectura y escritura.Al hacer clic en el enlace que figura en "Documentos relacionados", pueden accederse a todos los trabajos de Lucas Gagliardi presentes en el repositorio.Radio Universidad Nacional de La Plat
<i>No se sabe</i>: entrevista a Laura Sombra del Río
No full textEntrevista a la profesora de Matemática Laura Sombra del Río, integrante del Instituto de Metodología Alternativa para la Enseñanza de la Ciencia (IMApEC). Se especializa en tecnología informática aplicada a la educación, especialmente de las ciencias duras como la matemática.Al hacer clic en el enlace que figura en "Documentos relacionados", pueden accederse a todos los trabajos de Laura Sombra del Río presentes en el repositorio.Facultad de Ingenierí
Proposal for an Unmade Film (Set in The Future)
No full textIn Search of the Unknown
Opening 13 February 5:00 – 7:00 p.m.
From 14-02-2009 until 25-04-2009
Neïl Beloufa (FR), Persijn Broersen & Margit Lukács (NL), Heman Chong (SG), Graham Ellard & Stephen Johnstone (UK), Johannes Heldén (SE), Sebastian Diaz Morales (AR/NL), Ann Lislegaard (NO), r a d i o q ua l i a (NZ), Semiconductor (UK), Mark Aerial Waller (UK).
The Netherlands Media Art Institute supports media art in three core areas: presentation, research and conservation. At the same time, through its facilities it offers extensive services for artists and art institutions. Among these services are educational programs, to be developed to accompany all activities.
‘Proposal for an Unmade Film (Set in The Future)’ 16mm film also shown at:
VIDEOX EXPERIMENTAL FILM FESTIVAL, ZURICH, SWITZERLAND (Landscape programme curated by No.w.here, London), May 2009.
38e INTERNATIONAL FILM FESTIVA,L ROTTERDAM, THE NETHERLANDS, (HiddenFutures programme) 21st Jan -1st Feb 2009.
FESTIVAL FOR EXPANDED MEDIA, 22ND FILMWINTER, STUTTGART, GERMANY, 22nd Jan-25th Jan 2009.
22ND LEEDS INTERNATIONAL FILM FESTIVAL, LEEDS (Kinetika section), 5th-16th Nov 2008.
OBERHAUSEN SHORT FILM FESTIVAL, OBERHAUSEN, GERMANY (selected for exhibition by Lux, London), June 2008.
GREENWICH PICTUREHOUSE with TJ Wilcox and Emily Wardill, Feb 2008
Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations
No full textObjective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY). To date, mutation screening has been limited to patients with a family history consistent with MODY. In this study, we investigated the prevalence of HNF4A mutations in a large cohort of patients with diazoxide responsive hyperinsulinemic hypoglycemia (HH).
Subjects and methods: We sequenced the ABCC8, KCNJ11, GCK, GLUD1, and/or HNF4A genes in 220 patients with HH responsive to diazoxide. The order of genetic testing was dependent upon the clinical phenotype.
Results: A genetic diagnosis was possible for 59/220 (27%) patients. KATP channel mutations were most common (15%) followed by GLUD1 mutations causing hyperinsulinism with hyperammonemia (5.9%), and HNF4A mutations (5%). Seven of the 11 probands with a heterozygous HNF4A mutation did not have a parent affected with diabetes, and four de novo mutations were confirmed. These patients were diagnosed with HI within the first week of life (median age 1 day), and they had increased birth weight (median +2.4 SDS). The duration of diazoxide treatment ranged from 3 months to ongoing at 8 years.
Conclusions: In this large series, HNF4A mutations are the third most common cause of diazoxide responsive HH. We recommend that HNF4A sequencing is considered in all patients with diazoxide responsive HH diagnosed in the first week of life irrespective of a family history of diabetes, once KATP channel mutations have been excluded
<i>No se sabe</i>: entrevista a José Eduardo Jorge
No full textEntrevista al investigador de la UNLP José Eduardo Jorge, especialista en cultura política. Jorge, además, es miembro del Consejo Directivo del Instituto de Investigación en Comunicación (IICOM), director de proyectos de investigación acreditados y autor de un centenar de artículos científicos y de divulgación sobre Cultura Política y Comunicación Política. Autor también del libro Cultura Política y Democracia en Argentina (Edulp, 2010). Revisor de artículos científicos de la revista Questión.Al hacer clic en el enlace que figura en "Documentos relacionados", pueden accederse a todos los trabajos de José Eduardo Jorge presentes en el repositorio.Radio Universidad Nacional de La Plat
<i>No se sabe</i>: entrevista a Nilda Ester Radman
No full textEntrevista a la médica veterinaria y bacterióloga clínica industrial Nilda Ester Radman, profesora titular de Parasitología Comparada en la Facultad de Ciencias Veterinarias de nuestra universidad y estudiosa de las enfermedades zoonóticas.Al hacer clic en el enlace que figura en "Documentos relacionados", pueden accederse a todos los trabajos de Nilda Ester Radman presentes en el repositorio.Radio Universidad Nacional de La Plat
<i>No se sabe</i>: entrevista a Favio Shifres
No full textEntrevista al Dr. Favio Shifres, Profesor de Conjuntos Instrumentales y de Cámara y Licenciado en Dirección Orquestal (UNLP) y PhD (University of Roehampton). Profesor Titular de Educación Auditiva, Educación Musical Comparada y Desarrollo de Proyectos en Música, Facultad de Bellas Artes (UNLP). Integra el Consejo Asesor del Laboratorio para el Estudio de la Experiencia Musical (LEEM) de la Facultad de Bellas Artes (UNLP). Editor de la revista Epistemus, y miembro del comité editorial de varias revistas internacionales. Autor de libros, capítulos y artículos en revistas de la especialidad. Miembro fundador y ex presidente de la Sociedad Argentina para las Ciencias Cognitivas de la Música.Al hacer clic en el enlace que figura en "Documentos relacionados", pueden accederse a todos los trabajos de Favio Shifres presentes en el repositorio.Radio Universidad Nacional de La Plat
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