55 research outputs found
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Cardiac Electrophysiological Mapping And Ventricular Tachycardia In A Model Of Chronic Heart Failure
No full textIn the United States, one in three deaths are attributed to cardiovascular disease (CVD) (1). Within CVD, sudden cardiac death (SCD) is an increasingly common cause of mortality, by way of ventricular tachycardia (VT) and ventricular fibrillation. A positive correlation has been found between the presence of ischemic heart failure and the likelihood of inducible VT (2-5) as well as the presence of coronary artery disease and the likelihood of experiencing SCD (6). We have developed custom electrophysiology (EP) software (7) to perform examinations to distinguish between the sub-types of ischemic myocardium in rats. Furthermore, I am able to display EP data in two dimensional colormap arrays to provide a spatially-oriented image of the myocardium. Our software is also able to induce VT, in a consistent, minimally invasive manner.
Now that I have established a consistent difference in mapping and arrhythmia (8) between healthy myocardium and damaged myocardium in our model of ischemic heart failure, I have the opportunity to investigate the mechanisms by which adverse cardiac remodeling leads to an increased risk of SCD, investigate therapies, as well as an opportunity to investigate other animal models of ischemic or non-ischemic cardiomyopathies for model phenotype validation and subsequent treatment effectiveness
Common Method Variance & Bias dalam Penelitian Psikologis
No full textThe issue of common method variance and bias in Indonesia still has not gained much attention; even the terminology is less popular, except among psychometric enthusiasts and experts. In fact, the potential for common method variance and bias infiltrating in research results is very high, especially in studies that use a single method, a single source, and concurrent design, which are highly favored by psychological lecturers and researchers in Indonesia. This paper is a critical review, exposing the debate and serious impact regarding common method variance and bias, as well as procedures for detecting, addressing and correcting its effects. The author hoped this paper contributes in filling the gap in the literature, especially in Psychology Research Methodology text books in the Indonesian language, so that psychological researches in Indonesia continue to increase their quality and to have their better place in international publications
‘There are No Such Great Philosophies’: Contested Meanings of Toasebio Parish in Jakarta
No full textThis present study aims at exploring the meaning of the building of Santa Maria de Fatima Catholic Church (abbreviated as: SMFCC) or Toasebio Parish located in District Glodok, Jakarta, Indonesia. The author exposes in advance the meaning of the physical elements of the building SMFCC as understood by history writers and building experts. These meanings are not inseparable from the elements of human activities in the building. Through qualitative methods and literature review, the author describes in the Results section, how those meanings can be further interpreted through the existing studies and expressions of the SMFCC Parish Head. It is found that these meanings are contested − from the direction of religious faith and of culture − but complete our understandings of the church which is well-known as an Indonesian cultural heritage and dominated by Chinese and pastors from Europe
‘There are No Such Great Philosophies’: Contested Meanings of Toasebio Parish in Jakarta
No full textThis present study aims at exploring the meaning of the building of Santa Maria de Fatima Catholic Church (abbreviated as: SMFCC) or Toasebio Parish located in District Glodok, Jakarta, Indonesia. The author exposes in advance the meaning of the physical elements of the building SMFCC as understood by history writers and building experts. These meanings are not inseparable from the elements of human activities in the building. Through qualitative methods and literature review, the author describes in the Results section, how those meanings can be further interpreted through the existing studies and expressions of the SMFCC Parish Head. It is found that these meanings are contested − from the direction of religious faith and of culture − but complete our understandings of the church which is well-known as an Indonesian cultural heritage and dominated by Chinese and pastors from Europe
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Modulating Arrhythmogenic Reentrant Circuits With Engineered Biomaterials
No full textCardiovascular disease is one of the most common diseases in the world. Coronary artery disease increases the risk of an eventual heart failure diagnosis, and heart failure with reduced ejection fraction portends risk of reentrant arrhythmias such as monomorphic ventricular tachycardia. This tachyarrhythmia can be described as a single circuit composed of a depolarizing wavefront, an inactivated body, and a repolarizing tail that leaves an excitable gap. Though four mainstay therapies are used to treat monomorphic ventricular tachycardia and thereby decrease the risk of sudden cardiac death, an untapped opportunity lies in using an electrically insulating synthetic biomaterial to modulate the activity of the reentrant circuit without the shortcomings associated with drugs, ablation, implantable cardioverter defibrillators, and renal denervation procedures.
First, the model used to recapitulate human heart failure and associated monomorphic ventricular tachycardia must undergo validation regarding the ability of the model to reproduce what is observed clinically, as well as characterization of the time-dependent remodeling process and arrhythmia incidence in the model. Second, a thorough evaluation of the infarcted myocardium in the model must be done, specifically by a novel electrophysiologic mapping parameter derived from an extremely narrow field-of-view. Third and finally, the biomaterial intervention can be evaluated in both in vitro and in vivo experiments to support or refute the hypothesized mechanism of action, the primary endpoint of ventricular repolarization prolongation, and the secondary endpoint of decreased arrhythmogenesis.
The rodent model of heart failure with reduced ejection fraction was found to successfully recapitulate the prognostic factors associated with adverse ventricular remodeling, and also revealed a plateau in electrical instability and reentrant arrhythmogenesis after permanent left coronary artery ligation. Monophasic action potential amplitude was evaluated as a potential alternative to perform high resolution electroanatomic maps of the heart, but failed to produce as accurate quantification of scar burden as compared to the gold-standard bipolar voltage amplitude. Implantation of Polyglactin 910 on the epicardium of rats in heart failure produced a statistically significant increase in border region ventricular effective refractory period, and a physiologically relevant decrease in the incidence of inducible monomorphic ventricular tachycardia.
These findings defend the utility of rodent models to study the electrophysiologic perturbations associated with heart failure with reduced ejection fraction. In addition, quantitative and qualitative data support the use of monophasic action potential amplitude to distinguish the three subtypes of tissue in an infarcted myocardium. Finally, a novel class of antiarrhythmic therapy may be achieved in prolonging local effective refractory period to quench the excitable gap of reentrant tachyarrhythmias.Release after 01/12/202
Mempertanyakan Pemrofilan Kriminal Sebagai Sebuah Ilmu Psikologis
No full textDescription: Psychology contributes to criminal profiling process. Unfortunately, after intensive review on latest research findings, it is detected that most criminal profiling process is not based on strong scientific assumptions. This article explains the reasons why criminal profiling is quite a problem for psychology as a science. The author proposes several ideas to overcome this problem. The first idea is about the accurate understanding of criminal profiling scientific status. The science-pseudoscience-non science dichotomy and protoscience-science spectrum will support this understanding. The second idea is that there are some things to be considered for criminal profiling in order to be a prestigious discipline and be used scientifically appropriate by scientists and practitioners of forensic psychology and criminology
Mempertanyakan Pemrofilan Kriminal sebagai Sebuah Ilmu Psikologis
No full textPsychology contributes to criminal profiling process. Unfortunately, after intensive review on latest research findings, it is detected that most criminal profiling process is not based on strong scientific assumptions. This article explains the reasons why criminal profiling is quite a problem for psychology as a science. The author proposes several ideas to overcome this problem. The first idea is about the accurate understanding of criminal profiling scientific status. The science-pseudoscience-non science dichotomy and protoscience-science spectrum will support this understanding. The second idea is that there are some things to be considered for criminal profiling in order to be a prestigious discipline and be used scientifically appropriate by scientists and practitioners of forensic psychology and criminology
Mempertanyakan Pemrofilan Kriminal sebagai Sebuah Ilmu Psikologis
No full textPsychology contributes to criminal profiling process. Unfortunately, after intensive review on latest research findings, it is detected that most criminal profiling process is not based on strong scientific assumptions. This article explains the reasons why criminal profiling is quite a problem for psychology as a science. The author proposes several ideas to overcome this problem. The first idea is about the accurate understanding of criminal profiling scientific status. The science-pseudoscience-non science dichotomy and protoscience-science spectrum will support this understanding. The second idea is that there are some things to be considered for criminal profiling in order to be a prestigious discipline and be used scientifically appropriate by scientists and practitioners of forensic psychology and criminology
Mempertanyakan Pemrofilan Kriminal Sebagai Sebuah Ilmu Psikologis
No full textDescription: Psychology contributes to criminal profiling process. Unfortunately, after intensive review on latest research findings, it is detected that most criminal profiling process is not based on strong scientific assumptions. This article explains the reasons why criminal profiling is quite a problem for psychology as a science. The author proposes several ideas to overcome this problem. The first idea is about the accurate understanding of criminal profiling scientific status. The science-pseudoscience-non science dichotomy and protoscience-science spectrum will support this understanding. The second idea is that there are some things to be considered for criminal profiling in order to be a prestigious discipline and be used scientifically appropriate by scientists and practitioners of forensic psychology and criminology
Mempertanyakan Pemrofilan Kriminal Sebagai Sebuah Ilmu Psikologis
No full textDescription: Psychology contributes to criminal profiling process. Unfortunately, after intensive review on latest research findings, it is detected that most criminal profiling process is not based on strong scientific assumptions. This article explains the reasons why criminal profiling is quite a problem for psychology as a science. The author proposes several ideas to overcome this problem. The first idea is about the accurate understanding of criminal profiling scientific status. The science-pseudoscience-non science dichotomy and protoscience-science spectrum will support this understanding. The second idea is that there are some things to be considered for criminal profiling in order to be a prestigious discipline and be used scientifically appropriate by scientists and practitioners of forensic psychology and criminology
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