1,720,957 research outputs found
Patologie dermatologie e rischio di neoplasia in pazienti portatori di trapianto di rene: revisione della casistica torinese
No full textL’insufficienza renale cronica determina la comparsa di specifiche alterazioni cutanee; cute e rene sono, infatti, complementari nella funzione emuntoria e nel mantenimento dell’omeostasi idro-elettrolitica, termica e della pressione arteriosa. Con il ripristino della funzionalità renale conseguente al trapianto, molte di queste condizioni patologiche vanno incontro a regressione. Tuttavia è noto dalla letteratura che altre patologie, quali le infezioni o le neoplasie della cute, si manifestano nei soggetti portatori di trapianto con frequenza maggiore rispetto alla popolazione non trapiantata.
Scopo di questo lavoro è valutare su una casistica di pazienti sottoposti a trapianto di rene presso il Centro Trapianti di Torino, l’effettiva incidenza di neoplasie cutanee e di altre patologie di competenza dermatologica e la correlazione tra queste, il tipo e la durata del trattamento immunosoppressivo e gli altri fattori di rischio endogeni ed esogeni; i dati sono stati elaborati mediante analisi univariata e multivariata.
Sono stati presi in considerazione complessivamente 283 pazienti (175 maschi e 108 femmine), sottoposti a trapianto di rene tra il 1974 e il 2009. L’età mediana al trapianto era di 50 anni (range 11-76). Al momento della visita dermatologica di controllo l’età mediana era di 58 anni (range 23-82), mentre il tempo mediano intercorso dalla data del trapianto era di 7,2 anni.
Per tutti i pazienti è stata valutata il tipo e la durata della terapia immunosoppressiva e la presenza di altri eventuali fattori di rischio endogeni (fototipo, familiarità...) o esogeni (esposizione solare o a fonti artificiali di UV professionale o ricreativa, pregresse ustioni...). In quattro pazienti all’anamnesi risultava l’exeresi di una neoplasia cutanea (3 epiteliomi, 1 melanoma) precedente il trapianto; altri 99 (34.5%) al momento della visita sono risultati affetti da una precancerosi (8) o una neoplasia (66 epiteliomi, 8 melanomi, 17 altre) insorta nel periodo successivo al trapianto. I melanomi erano prevalentemente “in situ” o sottili; tra gli epiteliomi, l’istotipo spinocellulare era rappresentato più frequentemente rispetto alla popolazione non trapiantata e costituiva il 33.3% delle diagnosi. Per entrambe le neoplasie, le sedi più colpite erano quelle fotoesposte e i soggetti con maggior rischio erano quelli di età più avanzata, con fototipo chiaro o anamnesi positiva per ustioni solari.
Nel 12.4% dei pazienti sono state diagnosticate infezioni cutanee; queste erano nella maggior parte dei casi rappresentate da patologie virali (verruche, molluschi contagiosi) o micotiche (onicomicosi) di scarsa rilevanza clinica e comunque non tali da rendere necessaria la modificazione del trattamento immunosoppressivo. Le patologie cutanee infiammatorie croniche e autoimmuni erano scarsamente rappresentate, probabilmente come conseguenza di un ruolo terapeutico indiretto svolto dalla terapia immunosoppressiva. Anche per quanto riguarda gli effetti secondari di competenza dermatologica conseguenti alla terapia antirigetto non sono state osservate manifestazioni di particolare rilievo; il farmaco più frequentemente implicato era il cortisone e l’effetto più comunemente osservato la follicolite.
In conclusione, la nostra esperienza conferma la necessità di un adeguato follow-up dermatologico per i pazienti sottoposti a trapianto di rene; i tempi e le modalità dei controlli devono però essere valutati prendendo in considerazione non solo la durata e il tipo di terapia immunosoppressiva ma anche le caratteristiche fenotipiche del paziente e la presenza di altri eventuali fattori di rischio
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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