123 research outputs found
Correction to: Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot (Genetics in Medicine, (2021), 23, 10, (1952-1960), 10.1038/s41436-021-01212-y)
No full textDue to a processing error the author’s Doris Škorić-Milosavljević, Najim Lahrouchi, Alex V. Postma, Connie R. Bezzina were assigned to affiliation 38. However, affiliation 38 does not exist. In addition, the affiliations of Najim Lahrouchi, Elisabeth M. Lodder, and Connie R. Bezzina should be number 1 instead of number 2. The correct affiliation is Department of Clinical and Experimental Cardiology, Amsterdam University Medical Center, Amsterdam, The Netherlands. The original article has been corrected
Loneliness and hypervigilance to social cues: An eye-tracking study
No full textThis data deposit contains data from the project “Loneliness and Hypervigilance to Social Cues in Females: An Eye-Tracking Study”
The dataset contains the following data:
- File 0: Questionnaire data. Contains the questionnaires loneliness (UCLA), social anxiety (SPIN) and depression (CES-D), and information on who is in the lonely and nonlonely group (lonely_group).
- File 1: Eye-tracking data from the first task
- File 2: Eye-tracking data from the second task
- File 3: Eye-tracking data from the third task
- File 4: Eye-tracking data from the fourth task
All eye-tracking files contain all fixations that were measured during the eye-tracking task.
The process for aggregating these data is described in the paper “Loneliness and Hypervigilance to Social Cues in Females: An Eye-Tracking Study”.
The syntaxes for creating these data can be obtained by contacting the first author of the study (Gerine Lodder)
Loneliness and hypervigilance to social cues: An eye-tracking study
No full textItem does not contain fulltextThis data deposit contains data from the project “Loneliness and Hypervigilance to Social Cues in Females: An Eye-Tracking Study”
The dataset contains the following data:
- File 0: Questionnaire data. Contains the questionnaires loneliness (UCLA), social anxiety (SPIN) and depression (CES-D), and information on who is in the lonely and nonlonely group (lonely_group).
- File 1: Eye-tracking data from the first task
- File 2: Eye-tracking data from the second task
- File 3: Eye-tracking data from the third task
- File 4: Eye-tracking data from the fourth task
All eye-tracking files contain all fixations that were measured during the eye-tracking task.
The process for aggregating these data is described in the paper “Loneliness and Hypervigilance to Social Cues in Females: An Eye-Tracking Study”.
The syntaxes for creating these data can be obtained by contacting the first author of the study (Gerine Lodder)
Understanding cardiac electrical phenotypes in the genomic era
No full textSudden cardiac death (SCD) is defined as unexpected death due to a cardiac cause. It most often results from life-threatening ventricular fibrillation (VF) and ranks among the most common causes of death worldwide, with an incidence in the community varying between 0.6 and >1.4 per 1,000 individuals. Because SCD mostly occurs in individuals without previously known cardiac disease, the identification of patients at risk for SCD and implementation of preventive measures could save many lives. The etiology of SCD is complex and susceptibility to SCD is likely governed by a combination of inherited and environmental factors. The identification of genetic factors that modulate risk for sudden cardiac arrest (SCA) is important as it allows the pre-symptomatic identification of individuals at risk for SCA. The identification of such genetic factors also provides molecular leads for mechanistic studies that may in turn lead to better-targeted therapies. Similarly, as the electrocardiogram (ECG) reflects the electrical activity of the heart (and is instrumental for the diagnosis of many cardiac disorders), a deep understanding of molecular factors that modulate the different ECG parameters is pertinent. This thesis has accordingly focused on the identification of novel genes and genetic variants that (i) are associated with cardiac disease and SCD in affected families, or (ii) modulate ECG parameters. The thesis primarily focused on the genetics of cardiac electrical phenotypes (a word that stems from the Greek words phainein meaning "to show" and typos meaning "type"). To achieve this aim we used a broad range of state-of-the-art technologies and experimental approaches ranging from human genetic studies to studies in genetically engineered mice
Loneliness and hypervigilance to social cues: An eye-tracking study
No full textThis data deposit contains data from the project “Loneliness and Hypervigilance to Social Cues in Females: An Eye-Tracking Study”
The dataset contains the following data:
- File 0: Questionnaire data. Contains the questionnaires loneliness (UCLA), social anxiety (SPIN) and depression (CES-D), and information on who is in the lonely and nonlonely group (lonely_group).
- File 1: Eye-tracking data from the first task
- File 2: Eye-tracking data from the second task
- File 3: Eye-tracking data from the third task
- File 4: Eye-tracking data from the fourth task
All eye-tracking files contain all fixations that were measured during the eye-tracking task.
The process for aggregating these data is described in the paper “Loneliness and Hypervigilance to Social Cues in Females: An Eye-Tracking Study”.
The syntaxes for creating these data can be obtained by contacting the first author of the study (Gerine Lodder)
Technisch rapport Duinafslag
No full textDe TAW Leidraad Duinafslag van 1984 is vervangen door dit Technisch Rapport Duinafslag 2006 (TRDA2006). De hoofdreden daarvoor is dat er indertijd bij het opstellen van de Leidraad 1984 niet voldoende rekening is gehouden met het effect dat de golfperiode heeft op de mate van duinafslag. Metingen van golfkarakteristieken hebben inmiddels laten zien dat er tijdens zware stormvloedomstandigheden langere golfperioden kunnen voorkomen (Tp ? 16 - 20 s) dan waar indertijd rekening mee werd gehouden (Tp = 12 s). Met de procedures die in het TRDA2006 worden beschreven, wordt wel met het effect van deze langere golfperioden rekening gehouden. Daarnaast zijn er enkele andere nieuwe inzichten in het TRDA2006 verwerkt.TAW/EN
Mouse models in Arrhythmogenic Right Ventricular Cardiomyopathy
No full textArrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disorder characterized by fibrofatty replacement of cardiomyocytes. The cardinal manifestations are arrhythmias, sudden cardiac death and seldom heart failure. Mutations in genes encoding desmosomal proteins and their interaction partners have been implicated in the pathogenesis of ARVC and it is now widely accepted that ARVC is a disease caused by abnormal cell-cell adhesion due to defects in desmosomes. The mechanism(s) by which mutations in desmosomal proteins lead to fibro-fatty replacement remains to be fully elucidated. To this aim over the last 10 years different transgenic and targeted mouse models have been developed, these models and what they have taught us will be discussed in this review
Modeling the effects of hard structures on dune erosion and overwash
No full textMany of the most densely populated areas are located near the coast. Climate change and population growth put more and more pressure on these coastal areas. As free space is becoming sparse, coastal disaster risk reduction plans need to be spatially efficient. In this thesis the sandy coast with hard structures, such as buildings or dune revetments, is addressed. These structures can either provide additional protection or enhance erosion. Field measurements and experimental data featuring these phenomena are scarce, but the measurements of the devastating impact of Hurricane Sandy (October 2012) on the New Jersey shore provide new model validation possibilities. Hard structures in the barrier have three effects: 1) The main effect of a structure is the impact on the sand balance (both cross-shore and longshore), by cutting of (part) of the supply of sediment (WL | Delft Hydraulics, 1987). 2) In cross-shore direction a structure may result in the development of scour at the toe as a result of higher energetic conditions at the toe. However, in the post-Sandy bathymetry at the (buried) seawall at Bay Head, NJ, no scour holes were found. XBeach (Roelvink et al., 2009) simulations have reproduced these profiles and suggests this is the result of infilling of scour after the peak of Sandy. 3) In longshore direction a hard element will result in the extra erosion at the sides of the structure as a result of exchange of sediment and locally higher short waves. XBeach simulations have shown that the presence of a condo at Camp Osborne, NJ, during Sandy resulted in 32% additional erosion in adjacent locations However, these effects are no reason to state on forehand that multifunctional use of the barrier is not possible. Its applicability needs to be addressed case-by-case. Process-based models, like XBeach, can accurately reproduce the effects noticed in the field. Calculation rules, like Deltares and Arcadis (2013), do not reflect the true complexity, but can give a rough first indication of the longshore effect.Coastal EngineeringHydraulic EngineeringCivil Engineering and Geoscience
Explaining the Relevance of Court Decisions to Laymen
No full textIn the context of intelligent disclosure of case law, we report on our findings with respect to the presentation of relevant court decisions back to the laymen users. For this presentation we first localize the relevant legal concepts in the cases using shallow NLP techniques. Hereafter we investigated the use of techniques from the field of recommender systems, i.e. keyword style explanation and influence style explanation, to present the cases to the user in an understandable way. In order to find out if we succeeded in that respect, we conducted a small user satisfaction research. It shows promising results, and gives us some directions for future research
Detecting anthropogenic volume changes in cross sections of a sandy beach with permanent laser scanning
No full textCoastal areas world wide are highly dynamic areas, subject to continuous deformation processes. Both natural and anthropogenic processes constantly cause changes at various spatial scales. Sandy beaches in the Netherlands fall under a regulation, according to which moving sand is permitted, if the volume change remains below a certain threshold. The threshold holds for volume changes within a cross section of 1 m width of the beach. The enforcement of this rule is currently labor intensive, because monitoring generally happens only on a yearly basis, or incidental and non-quantitative. Improved observation capabilities with remote sensing are advancing the supporting technology for this kind of regulations. Permanent laser scanning is a potential tool for monitoring and quantifying volume changes of a section of the beach. We develop and implement methodology to extract time series of volume change with respect to a reference date of 01-01-2020 covering January 2020 until the end of April 2020. The method is applied on point cloud data from a permanent laser scanner on the coast of Noordwijk, The Netherlands. We analyse the time series for incidents, where the threshold in volume change is passed, and find all shortest intervals during which the threshold is passed. Then we analyse potential underlying cause in order to support not only enforcement, but also evaluation of the current regulation. This will ultimately help to work towards a better understanding of the influence of small scale human activities on coastal development. Optical and Laser Remote SensingPolicy AnalysisCoastal Engineerin
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