1,720,952 research outputs found
Control-theoretic methods for biological networks
No full textFeedback is both a pillar of control theory and a pervasive principle of nature. For this reason, control-theoretic methods are powerful to analyse the dynamic behaviour of biological systems and mathematically explain their properties, as well as to engineer biological systems so that they perform a specific task by design. This paper illustrates the relevance of control-theoretic methods for biological systems. The first part gives an overview of biological control and of the versatile ways in which cells use feedback. By employing control-theoretic methods, the complexity of interlaced feedback loops in the cell can be revealed and explained, and layered feedback loops can be designed in the cell to induce the desired behaviours, such as oscillations, multi-stability and activity regulation. The second part is mainly devoted to modelling uncertainty in biology and understanding the robustness of biological phenomena due to their inherent structure. Important control-theoretic tools used in systems biology are surveyed. The third part is focused on tools for model discrimination in systems biology. A deeper understanding of molecular pathways and feedback loops, as well as qualitative information on biological networks, can be achieved by studying the “dynamic response phenotypes” that appear in temporal responses. Several applications to the analysis of biological systems are showcased.Accepted Author ManuscriptTeam Tamas Keviczk
Regulating privatized infrastructures and airport services
Full text linkFor a World Bank Institute course on transport privatization, the authors cover basic issues associated with the regulation of privatized airport infrastructure and services: 1) Economic characteristics of airport. Three types of activities are carried out in airports: essential operational services (aeronautical and non-aeronautical), handling services (aeronautical and non-aeronautical), and commercial activities. Demand for basic airport services is directly influenced by trip purpose. The two types of airline customers (business and leisure travelers) need different levels of flexibility and tend to travel at different times. Analyzing airport capacity (practical and saturation) under peak demand is essential to airport success. Among other important issues: runway cost, level and volume of service, pollution, congestion, and air traffic control. 2) Recent trends in the airport industry. The movement toward privatization may involve public ownership and private operation, including joint ventures; partial or majority divestiture; management contracts; and BOT (build-operate-transfer) schemes and variants, including BOOT (build-own-operate-transfer) schemes and LDO (lease-develop-operate) schemes. Or it may involve private ownership and operation. 3) Price regulation. Topics covered include traditional pricing policies'price regulation through an RPI-X formula; charges for congestion, noise, and other externalities; investment plans; and design of the regulatory system. 4) Regulation of quality in the industry. Topics covered: regulation of services to passengers (as measured by targets for check-in queues, immigration queues, baggage reclaim queues, concourse crowding, shopping, parking, and so on); fault repair times; average levels of passenger boarding and disembarkation and baggage delivery; safety; and investment obligation. 5) Performance indicators in the industry. Topics covered: strategic indicators and other financial indicators (including revenues), as well as indicators of cost, productivity, and quality of service.Transport and Trade Logistics,Public Sector Economics&Finance,Banks&Banking Reform,Environmental Economics&Policies,Decentralization,Roads&Highways,Airports and Air Services,Public Sector Economics&Finance,Banks&Banking Reform,Transport and Trade Logistics
EL LaunchPad: Creating a practical online resource for elementary teachers of English language learners from the educator perspective
Full text linkThe purpose of this project is to develop a practical website for elementary teachers of English learners (ELs). Initial research states ELs are the fastest growing population in k-12 education in the U.S., revealing a need for teacher access to effective materials and a community of support and collaboration. Existing websites are evaluated to assess the gap in features of these resources and how to move forward in website development. In addition, in-service elementary EL teachers are surveyed to establish teacher opinion for an online resource and influence web design and available content. Finally, based on the research phases of the project, a website for teachers that promotes a space for community connection, collaboration, and the sharing of teaching materials is designed, developed and launched: EL LaunchPad.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-12-01The student, Hana Kearfott, accepted the attached license on 2018-12-06 at 21:50.The student, Hana Kearfott, submitted this Thesis for approval on 2018-12-06 at 21:59.This Thesis was approved for publication on 2018-12-10 at 08:38.DSpace SAF Submission Ingestion Package generated from Vireo submission #13233 on 2019-02-07 at 14:22:56Made available in DSpace on 2019-02-07T20:44:25Z (GMT). No. of bitstreams: 2
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The public sector in the Caribbean : issues and reform options
Full text linkThe public sector's performance in the Caribbean varies, in reducing poverty and in creating an enabling environment for growth. Barbados and the Bahamas have been the high performers, Guyana and the Dominican Republic have been sluggish, and the other Caribbean countries fall in between. In the Caribbean region, the public sector is now the predominant provider of tertiary education and health services (university education and hospital-based curative care), which mainly benefit the nonpoor. Attempts must be made to recover costs from high-income users and use that revenue to improve the quality and quantity (as appropriate) of basic services. Lessons from experience suggest that most Caribbean countries need to encourage the private sector to participate more in providing infrastructure and need to provide a better regulatory framework. The good news: this is already taking place in many countries.Health Monitoring&Evaluation,Public Health Promotion,Public Sector Economics&Finance,Decentralization,Environmental Economics&Policies,Public Sector Economics&Finance,Health Monitoring&Evaluation,Poverty Assessment,National Governance,Inequality
Detective fiction in Cuban society and culture.
No full textPhDThe object of this thesis is to reach towards an understanding of Cuban society through a
study of its detective fiction and more particularly contemporary Cuban society through
the novels of the author and critic, Leonardo Padura Fuentes.
The method has been to trace the development of Cuban detective writing and to
read Padura Fuentes in the light of the work of twentieth century Western European
literary critics and philosophers including Raymond Williams, Antonio Gramsci, Terry
Eagleton, Roland Barthes, Jean Paul Sartre, Michel Foucault, Jean François Lyotard and
Jean Baudrillard in order to gain a better understanding of the social and historical
context from which this genre emerged.
By concentrating on the literary texts, I have explored readings which lead out into
an analysis of the broader philosophical, political and historical issues raised by the
Cuban revolution. Since it deals primarily with modes of deviance and notions of legality
and justice within the context of the modern state, detective fiction is particularly well
suited to this type of investigation. The intention is to show how this is as valid in the
Cuban context as it is in advanced capitalist societies where such research has already
been carried out with some success.
The thesis comprises an introduction, ten chapters and a conclusion. The chapters
are divided into three sections. Chapters 1 to 3 attempt a broad theoretical, historical and
socio-political analysis of the cultural reality within which the Cuban revolutionary
detective genre emerged. Chapters 4 to 6 analyse the Cuban detective narrative from its
inception in the early part of the twentieth century until the emergence of Leonardo
Padura Fuentes as the foremost exponent of the genre in Cuba after 1991. Chapters 7-
10 concentrate upon the work of Leonardo Padura Fuentes, offering a reading of his
detective tetralogy informed by the preceding discussion.
The contribution made by the thesis to knowledge of the subject is to build upon the
work of Seymour Menton and Amelia S. Simpson on the development of the Cuban
detective novel and to provide analyses of the pre-Revolutionary Cuban detective
narrative and the work of Leonardo Padura Fuentes for the first time in the English
language. The thesis concludes that the study of this popular genre in Cuba is of crucial
importance to the scholar who wishes to reach as full an understanding of the social
dynamics within that society as possible. In particular, it proves that Cuban detective
fiction provides a useful barometer of social change which records the shifts in the Cuban
Zeitgeist that have taken place over the past century
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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