2,066 research outputs found
Sex differences in Cognitive Abilities Test scores: a UK national picture
No full textBackground and aims. There is uncertainty about the extent or even existence of sex differences in the mean and variability of reasoning test scores ( Jensen, 1998; Lynn, 1994, ; Mackintosh, 1996). This paper analyses the Cognitive Abilities Test (CAT) scores of a large and representative sample of UK pupils to determine the extent of any sex differences.
Sample. A nationally representative UK sample of over 320,000 school pupils aged 11-12 years was assessed on the CAT (third edition) between September 2001 and August 2003. The CAT includes separate nationally standardized tests for verbal, quantitative, and non-verbal reasoning. The size and recency of the sample is unprecedented in research on this issue.
Methods. The sheer size of the sample ensures that any sex difference will achieve statistical significance. Therefore, effect sizes (d) and variance ratios (VR) are employed to evaluate the magnitude of sex differences in mean scores and in score variability, respectively.
Results. The mean verbal reasoning score for girls was 2.2 standard score points higher than the mean for boys, but only 0.3 standard points in favour of girls for non-verbal reasoning (NVR), and 0.7 points in favour of boys for quantitative reasoning (QR). However, for all three tests there were substantial sex differences in the standard deviation of scores, with greater variance among boys. Boys were over represented relative to girls at both the top and the bottom extremes for all tests, with the exception of the top 10% in verbal reasoning.
Conclusions. Given the small differences in means, explanations for sex differences in wider domains such examination attainment at age 16 need to look beyond conceptions of `ability'. Boys tend to be both the lowest and the highest performers in terms of their reasoning abilities, which warns against the danger of stereotyping boys as low achievers
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA
No full textTopoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires removal of topoisomerase II. To analyse removal of topoisomerase II from genomic DNA we adapted the trapped in agarose DNA immunostaining assay. Recombinant MRE11 from 2 sources removed topoisomerase IIalpha from genomic DNA in vitro, as did MRE11 immunoprecipitates isolated from A-TLD or K562 cells. Basal topoisomerase II complex levels were very high in A-TLD cells lacking full-length wild type MRE11, suggesting that MRE11 facilitates the processing of topoisomerase complexes that arise as part of normal cellular metabolism. In K562 cells inhibition of MRE11, PARP or replication increased topoisomerase IIalpha and beta complex levels formed in the absence of an anti-topoisomerase II dru
Strand separation establishes a sustained lock at the Tus-Ter replication fork barrier
No full textThe bidirectional replication of a circular chromosome by many bacteria necessitates proper termination to avoid the head-on collision of the opposing replisomes. In Escherichia coli, replisome progression beyond the termination site is prevented by Tus proteins bound to asymmetric Ter sites. Structural evidence indicates that strand separation on the blocking (nonpermissive) side of Tus-Ter triggers roadblock formation, but biochemical evidence also suggests roles for protein-protein interactions. Here DNA unzipping experiments demonstrate that nonpermissively oriented Tus-Ter forms a tight lock in the absence of replicative proteins, whereas permissively oriented Tus-Ter allows nearly unhindered strand separation. Quantifying the lock strength reveals the existence of several intermediate lock states that are impacted by mutations in the lock domain but not by mutations in the DNA-binding domain. Lock formation is highly specific and exceeds reported in vivo efficiencies. We postulate that protein-protein interactions may actually hinder, rather than promote, proper lock formation.Accepted Author ManuscriptBN/Nynke Dekker LabBN/Cees Dekker LabBN/Martin Depken La
A self-conscious Kurt Vonnegut: an analysis of Cat's Cradle, Slaughterhouse-Five and Breakfast of Champions
No full textThe works of Kurt Vonnegut stand as seminal in the American literary canon. Looking at three of his most influential novels, namely Cat's Cradle, Slaughterhouse-Five and Breakfast of Champions, this study aims to better understand the mechanisms which inform his fiction. Working chronologically through the novels, the study examines historical context, narrative technique, theoretical underpinnings and the social critique of each novel. Guided by an idea of the postmodern novel the study examines how these elements interact, concluding that by way of what may be considered "simple" yet self-conscious metafiction and prose as well as variations in narrative technique, Vonnegut is able to more accurately convey his opinions on the American situation as well as demonstrate his stance on the role of fiction and the writer in contemporary society. The study also considers closely the role of the reader and the author/reader/text relationship
Talking points: A modulating circle increases listening effort without improving speech recognition in younger adults
No full textThis page contains data, code, and preregistration for the paper with the same name in Psychonomic Bulletin & Review (2020).
This paper and the associated materials are a corrected version of a previous manuscript published in 2018 (https://link.springer.com/article/10.3758/s13423-018-1489-7). While attempting to replicate and extend the original work, the first author discovered an error in the stimulus presentation program that invalidated the results. This paper presents the corrected results.
Contact Julia Strand, [email protected]
Talking points: A modulating circle increases listening effort without improving speech recognition in younger adults
No full textThis page contains data, code, and preregistration for the paper with the same name in Psychonomic Bulletin & Review (2020).
This paper and the associated materials are a corrected version of a previous manuscript published in 2018 (https://link.springer.com/article/10.3758/s13423-018-1489-7). While attempting to replicate and extend the original work, the first author discovered an error in the stimulus presentation program that invalidated the results. This paper presents the corrected results.
Contact Julia Strand, [email protected]
An Observation of the Strand Theater
No full textThis article provides a history of The Strand Theater in downtown Binghamton NY based on fire insurance maps and the author\u27s observations
Identification of a novel type of spacer element required for imprinting in fission yeast
No full textAsymmetrical segregation of differentiated sister chromatids is thought to be important for cellular differentiation in higher
eukaryotes. Similarly, in fission yeast, cellular differentiation involves the asymmetrical segregation of a chromosomal
imprint. This imprint has been shown to consist of two ribonucleotides that are incorporated into the DNA during laggingstrand
synthesis in response to a replication pause, but the underlying mechanism remains unknown. Here we present key
novel discoveries important for unravelling this process. Our data show that cis-acting sequences within the mat1 cassette
mediate pausing of replication forks at the proximity of the imprinting site, and the results suggest that this pause dictates
specific priming at the position of imprinting in a sequence-independent manner. Also, we identify a novel type of cis-acting
spacer region important for the imprinting process that affects where subsequent primers are put down after the
replication fork is released from the pause. Thus, our data suggest that the imprint is formed by ligation of a not-fullyprocessed
Okazaki fragment to the subsequent fragment. The presented work addresses how differentiated sister
chromatids are established during DNA replication through the involvement of replication barriers
Paul Strand in Mexico, 1932-34
No full textThis book provides a definitive study of the photographer and filmmaker Paul Strand\u27s two years in Mexico from 1932-34. It was released simultaneously in English and Spanish. --author-supplied descriptio
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