1,721,214 research outputs found
Marec (Edwan), Monuments chrétiens d'Hippone, ville épiscopale de saint Augustin
No full textJanin Raymond. Marec (Edwan), Monuments chrétiens d'Hippone, ville épiscopale de saint Augustin. In: Revue des études byzantines, tome 17, 1959. pp. 269-270
Marec (Edwan), Monuments chrétiens d'Hippone, ville épiscopale de saint Augustin
No full textJanin Raymond. Marec (Edwan), Monuments chrétiens d'Hippone, ville épiscopale de saint Augustin. In: Revue des études byzantines, tome 17, 1959. pp. 269-270
Immunomodulation of Allergic Airway Inflammation by FLT3-ligand
No full textAllergic asthma is a chronic disease of the lungs associated with bronchoconstriction, increased type 2 (Th2) cytokines interleukin (IL-) 4, IL-5, IL-13, eosinophilia, and chronic inflammation in the airways. There has been a rapid increase in asthma prevalence in developed countries which was linked to decreased incidence of infectious diseases.|Since the recognition of distinct T helper cell subsets that differ in cytokine production and effector functions as it relates to asthma, challenging concepts have evolved to allow the use of therapeutic modalities that modulate the Thl/ Th2 balance in asthma without deleterious side effects. Primarily, these concepts have focused on modulation of antigen presentation to T cells and inhibition of antigen-specific Th2 responses and/or increasing the Thl response. Flt3-ligand (Flt3-L) is a growth factor for dendritic cells, and induces type 1 T cell responses. The receptor for Flt3L is a member of the type 111 tyrosine kinase receptor family. A series of experiments were designed to examine the ability of Flt3-L to reverse allergic airway inflammation in acute and chronic murine models of asthma. BALB/c mice were sensitized and challenged with ovalbumin (OVA) and airway hyperresponsiveness (AHR) to methacholine was established. The mice were then treated with FU3-L or Flt3-L plasmid. A comprehensive evaluation of the hallmarks of asthma was then performed, which included measurement of pulmonary functions and AHR to methacholine, bronchoalveolar lavage (BAL) eosinophilia, serum total and anti-OVA IgE, IgGl, and lgG2a, and serum and BAL cytokines. Treatment with Flt3-L and FU3-L plasmid in pre-sensitized mice significantly suppressed AFIR, BAL total cellularity and absolute eosinophil counts and inflammation in the lung tissue. FH3-L administration was observed to significantly decrease pro-inflammatory cytokines IL-4, and 1L-5 in BAL and serum. Furthermore, FU3-L prevented AHR in a murine model of chronic allergic airway inflammation. There was no significant effect of FU3-L treatment on serum total IgE levels. Flt3-L treatment also downregulated goblet cell hyperplasia, and basement membrane thickening.|These data suggest that Flt3-L and FU3-L plasmid treatment can reverse established experimental allergic airway inflammation and AHR, and might provide a novel approach for treating asthma.ProQuest Traditional Publishing Optionxxiii, 183 page
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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